Search

Your search keyword '"Ryazankina OI"' showing total 2 results
Start Over Author "Ryazankina OI" Topic variola virus
2 results on '"Ryazankina OI"'

1. Multiple genetic differences between the monkeypox and variola viruses.

Author

Shchelkunov SN, Totmenin AV, Safronov PF, Gutorov VV, Ryazankina OI, Petrov NA, Babkin IV, Uvarova EA, Mikheev MV, Sisler JR, Esposito JJ, Jahrling PB, Moss B, and Sandakhchiev LS

Subjects
Animals, Democratic Republic of the Congo, Genes, Viral genetics, Humans, Monkeypox virus isolation & purification, Monkeypox virus pathogenicity, Open Reading Frames genetics, Poxviridae Infections epidemiology, Poxviridae Infections transmission, Smallpox epidemiology, Smallpox transmission, Smallpox virology, Variola virus pathogenicity, Viral Proteins genetics, Virulence genetics, Evolution, Molecular, Monkeypox virus genetics, Poxviridae Infections virology, Variola virus genetics
Published
2002
Full Text
View/download PDF

2. Human monkeypox and smallpox viruses: genomic comparison.

Author

Shchelkunov SN, Totmenin AV, Babkin IV, Safronov PF, Ryazankina OI, Petrov NA, Gutorov VV, Uvarova EA, Mikheev MV, Sisler JR, Esposito JJ, Jahrling PB, Moss B, and Sandakhchiev LS

Subjects
Amino Acid Sequence, Ankyrins chemistry, Evolution, Molecular, Humans, Models, Genetic, Molecular Sequence Data, Open Reading Frames, Phylogeny, Protein Structure, Tertiary, Sequence Homology, Amino Acid, Virulence, Genome, Viral, Monkeypox virus genetics, Monkeypox virus pathogenicity, Variola virus genetics, Variola virus pathogenicity
Abstract

Monkeypox virus (MPV) causes a human disease which resembles smallpox but with a lower person-to-person transmission rate. To determine the genetic relationship between the orthopoxviruses causing these two diseases, we sequenced the 197-kb genome of MPV isolated from a patient during a large human monkeypox outbreak in Zaire in 1996. The nucleotide sequence within the central region of the MPV genome, which encodes essential enzymes and structural proteins, was 96.3% identical with that of variola (smallpox) virus (VAR). In contrast, there were considerable differences between MPV and VAR in the regions encoding virulence and host-range factors near the ends of the genome. Our data indicate that MPV is not the direct ancestor of VAR and is unlikely to naturally acquire all properties of VAR.

Published
2001
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results