1. [Metopic craniosynostosis, probable effect of intrauterine exposure to maternal valproate treatment].
- Author
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Chabrolle JP, Bensouda B, Bruel H, Simon A, Poinsot J, Ickowicz V, and Degre S
- Subjects
- Abnormalities, Drug-Induced diagnosis, Craniosynostoses diagnosis, Diseases in Twins, Female, Humans, Imaging, Three-Dimensional, Infant, Newborn, Male, Pregnancy, Tomography, X-Ray Computed, Twins, Dizygotic, Ultrasonography, Prenatal, Valproic Acid therapeutic use, Abnormalities, Drug-Induced etiology, Craniosynostoses chemically induced, Epilepsy, Generalized drug therapy, Pregnancy Complications drug therapy, Valproic Acid adverse effects
- Abstract
Unlabelled: Metopic craniosynostosis may be an adverse effect of valproic acid exposed fetus., Cases: We report two infants with metopic craniosynostosis, born to mothers who were treated with valproic acid. In one case, a prenatal diagnosis was made. In the other case, only the male dizygotic twin was affected., Conclusion: Trigonocephaly may be a symptom of valproate embryofoetopathy detectable by antenatal ultrasound examination.
- Published
- 2001
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