1. A Brain-Melanocortin-Vagus Axis Mediates Adipose Tissue Expansion Independently of Energy Intake.
- Author
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Holland J, Sorrell J, Yates E, Smith K, Arbabi S, Arnold M, Rivir M, Morano R, Chen J, Zhang X, Dimarchi R, Woods SC, Sanchez-Gurmaches J, Wohleb E, and Perez-Tilve D
- Subjects
- Adipose Tissue cytology, Adipose Tissue, Brown metabolism, Animals, Body Weight, Cell Proliferation, Diet, High-Fat, Liver surgery, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Rats, Rats, Wistar, Receptor, Melanocortin, Type 4 deficiency, Receptor, Melanocortin, Type 4 genetics, Signal Transduction, Vagotomy, Adipose Tissue metabolism, Brain metabolism, Energy Intake, Melanocortins metabolism, Vagus Nerve metabolism
- Abstract
The melanocortin system is a brain circuit that influences energy balance by regulating energy intake and expenditure. In addition, the brain-melanocortin system controls adipose tissue metabolism to optimize fuel mobilization and storage. Specifically, increased brain-melanocortin signaling or negative energy balance promotes lipid mobilization by increasing sympathetic nervous system input to adipose tissue. In contrast, calorie-independent mechanisms favoring energy storage are less understood. Here, we demonstrate that reduction of brain-melanocortin signaling actively promotes fat mass gain by activating the lipogenic program and adipocyte and endothelial cell proliferation in white fat depots independently of caloric intake via efferent nerve fibers conveyed by the common hepatic branch of the vagus nerve. Those vagally regulated obesogenic signals also contribute to the fat mass gain following chronic high-fat diet feeding. These data reveal a physiological mechanism whereby the brain controls energy stores that may contribute to increased susceptibility to obesity., (Copyright © 2019 The Author(s). Published by Elsevier Inc. All rights reserved.)
- Published
- 2019
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