1. Potential autoimmune encephalitis following yellow fever vaccination: A report of three cases.
- Author
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Guedes BF, Ribeiro AF, Pinto LF, Vidal JE, de Oliveira FG, Sztajnbok J, de Oliveira ACP, and Simabukuro MM
- Subjects
- Adolescent, Adult, Anti-N-Methyl-D-Aspartate Receptor Encephalitis diagnosis, Female, Humans, Yellow Fever immunology, Yellow Fever prevention & control, Anti-N-Methyl-D-Aspartate Receptor Encephalitis chemically induced, Anti-N-Methyl-D-Aspartate Receptor Encephalitis immunology, Nerve Tissue Proteins immunology, Vaccination adverse effects, Yellow Fever Vaccine adverse effects
- Abstract
Meningoencephalitis following yellow fever vaccination is considered a viral neuroinvasive disease. We describe three patients with typical autoimmune encephalitis syndromes that developed 1-27 days following yellow fever vaccination. Anti-N-methyl-d-aspartate-r antibodies were identified in the CSF and serum of two patients and the other case was associated with anti-neurexin-3 antibodies. One case was confirmed as vaccine-associated neurotropic disease due to reactive CSF yellow fever IgM, which suggested an infectious-autoimmune overlap mechanism. Two aditional cases of Anti-N-methyl-d-aspartate-r encephalitis were identified in the literature review. Antibody-positive autoimmune encephalitis should be included in the differential diagnosis of neurologic adverse events following yellow fever vaccination., (Copyright © 2021 Elsevier B.V. All rights reserved.)
- Published
- 2021
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