1. Efficacy of Clostridium botulinum types C and D toxoid vaccination in Danish cows.
- Author
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Krüger M, Skau M, Shehata AA, and Schrödl W
- Subjects
- Animals, Antibodies, Bacterial blood, Antitoxins blood, Bacterial Load, Bacterial Vaccines administration & dosage, Botulinum Toxins analysis, Botulism immunology, Botulism prevention & control, Cattle, Cattle Diseases immunology, Clostridium botulinum isolation & purification, Denmark, Enzyme-Linked Immunosorbent Assay, Feces chemistry, Feces microbiology, Spores, Bacterial isolation & purification, Toxoids administration & dosage, Bacterial Vaccines immunology, Botulinum Toxins immunology, Botulism veterinary, Cattle Diseases prevention & control, Toxoids immunology, Vaccination methods
- Abstract
In the present study the efficacy Botulism vaccine (formalinised aluminum hydroxide gel adsorbed toxoid of Clostridium botulinum types C and D) was evaluated in four Danish dairy cows under field conditions. Other four dairy herds were unvaccinated. Blood serum of all animals was analyzed for specific C. botulinum types A, B, C, D and E antibodies using a developed ELISA. Feces of all animals were analyzed for botulinum neurotoxins (BoNTs) and C. botulinum spores. C. botulinum types C and D antibodies were significantly (p < 0.05) increased in vaccinated animals. Vaccination with botulism vaccine significantly reduced (p < 0.001) BoNTs and C. botulinum spores in cattle feces. Our findings represent that C. botulinum vaccination increases specific blood serum antibodies and reduces free BoNTs and C. botulinum spores in feces., (Copyright © 2013 Elsevier Ltd. All rights reserved.)
- Published
- 2013
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