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We studied the volume compactness of the arterial, capillary and venous parts of the microcirculation channel after 24, 48, 72 and 96 hours of the aseptic inflammation and after local application of the carbon-mineral sorbents in the rat's uterus. The local sorption decreased the reaction of the inflammation in the endo- and myometrium.

Interrelations of the blood and lymphatic systems of the uterus have been examined in rats at pregnancy complicated with the ++phlebo-occlusive syndrome. Blood stream impediment in the caudal vena cava results in increasing diameter of the arterioles, capillaries and venules of the endo- and myometrium. Certain disturbances of blood circulation in the uterus at the ++phlebo-cclusive syndrome in the pregnancy animals, as a rule, reflect in the uterine lymph outflow; this is demonstrated as dilatation and deformity of the lymphatic vessels and capillaries, appearance of protrusions of the lymphatic vessels wall. There is a definite co-ordination in the reaction to the caudal vena cava occlusion in the intra-, ++extra-organic uterine lymphatic bed and in its regional lymph nodes, manifested as the following morphological signs: decreasing relative volume, that the lymphoid tissue occupies and increasing relative volume of the cortical and medullary intermediate sinuses.

In pregnant Wistar rats an essential rearrangement of the uterine blood-lymph circulatory bed has been revealed. It is possible that at the beginning of pregnancy it occurs for the change of the histiotrophic nutrition of the embryo into the hemotrophic one under effect of the trophoblast. Later on, when hemochorial relations between the mother and the fetus have been established, the continuous growth of the volumetric density and diameter of the vessels of the uterine microcirculatory bed can be connected with the intensive growth of the fetus and the extension of the yolk and allantois circulation reservoir. During these periods of pregnancy the mass of the placental labyrinth is doubled and vascularization of the extraembryonic organs increases. The circulatory changes occurring in the uterine placental zone get their reflection in the uterine regional lymph nodes. The investigation of the ultrastructural organization of endotheliocytes in the blood capillaries of the rat iliac lymph nodes during pregnancy reveals a complex of adaptive-structural rearrangements in them, first of all enlargement of the lumen in the arterial and venous parts of the capillaries, increasing fenestration of the arterial and venous parts of the capillaries, enhancing formation of micropinocytic vesicles and transendothelial canals. Thus, the complex of adaptive-compensatory rearrangements and interconnected, integrated reaction of the uterine microcirculatory bed with the analogous system of its regional iliac lymph nodes is revealed.

From the body of the rat uterus, the lymph outflows into the caudal lymph nodes and when the latter are absent--into the iliac lymph nodes. From the medial and middle parts of the uterine horn the lymph out flows into the iliac lymph nodes, and from the lateral part of the uterine horn--into the renal lymph nodes. Some parts of the lymph outflows into corresponding contralateral lymph nodes. If the mass of the caudal lymph nodes in pregnant animals does not significantly differ from those in nonpregnant animals, the mass of the iliac and renal nodes increases with pregnancy. Maximal increase of the iliac and renal lymph nodes mass coincides with completion of the alantoic placenta formation. It is probable that there is a positive correlative dependence between the number of embryos in the uterus and the mass both of the iliac and renal lymph nodes.

In the regional lymph nodes of the uterus the comparative volume of the paracortical zone significantly increases, especially within the period of the 13th-17th days of pregnancy. In the popliteal lymph node similar effect is not discovered. From the 7th up to the 11th day edema, vasodilatation, infiltration with special leucocytes are revealed. Endothelium of the postcapillary venules is hypertrophied, contains many migrating lymphocytes, which accumulate around the vessels mentioned. The volume of the microcirculatory bed is moderately increased. By the 17th day plasmoblasts, plasmocytes, Motta's cells, monocytes and especially macrophages appear in the paracortical zone. In B-zones and in medullary sinuses blasts, plasma cells, monocytes, macrophages, mitotically deviding cells increase in number. The part of the reticular cells decreases. The tensometric method demonstrates an increasing pressure of lymph in the iliac lymph node at pregnancy. Collateralies appear in the ovarian vein system, in the broad ligament of the uterus, in the lumbar area. The uterine vascular system is supposed to participate in adaptation to pregnancy. In genesis of the regional lymph node changes, discirculatory shifts, predominating during placental organogenesis, combine with phenomena of cell migration and proliferation (clearly revealed by the time when formation of the placenta is completed).

Structural adaptation of the vascular bed in the broad ligament of the dog uterus has been studied at various time of the experimental phlebohypertension. Restitution of the circulation after the posterior vena cava occulsion occurs phasically. The venous collateralies are not formed at one time and it is connected with the venous pressure level in the inferiocaval system and with some changes in the construction of the microcirculatory bed. Basing on the morphometry data, a general equation has been derived which reflects dynamics of the microangiological parameters and demonstrates unidirectionness of the adaptive reactions in the vascular bed at the disturbed venous circulation. Using principles of the system-structural analysis and the mathematical graph theory, we consider the microcirculatory system of the broad ligament of the uterus as a graph-system and study the reorganization of the microcirculatory network at a venous congestion. Realization of the compensatory possibilities is reached in the microcirculatory bed by a changed relationships in the number of the intervascular connections. The latter are estimated according to the graph-schemes of the microvascular bed. Morphokinetics of the connections between the vessels is characterized by widening or narrowing the borders of the "adaptive norm" and by changing the microangioarchitectonics. At the same time, there is noted formation of specialized microhemoangioconstructions. Morphofunctional state of the lymphatic system is connected with reorganization of the angioarchitectonics. This is certain manifestation of the law of the lymphatic and blood beds "synergism". Thus, the structural changes of the vascular bed are aimed to support a certain hemodynamic level.