1. Uterotropic effect of clofibrate and phenylbutazone in immature female rats.
- Author
-
Chandra D, Thulasimany M, and Biswas AR
- Subjects
- Animals, Drug Synergism, Estrogens, Ethinyl Estradiol pharmacology, Female, Organ Size drug effects, Pentobarbital antagonists & inhibitors, Rats, Sleep drug effects, Clofibrate pharmacology, Phenylbutazone pharmacology, Uterus drug effects
- Abstract
The uterotropic effect of clofibrate and phenylbutazone was studied in immature female rats. A significant increase in the uterine wet weight was observed following clofibrate and phenylbutazone administration. Clofibrate but not phenylbutazone synergized with the uterotropic effect of ethinyl-oestradiol. Phenylbutazone pretreatment significantly decreased the pentobarbitone sleeping time. The uterotropic effect of clofibrate and phenylbutazone might involve displacement of 17-beta oestradiol (or ethinyl oestradiol) from plasma albumin binding sites in rats.
- Published
- 1982