1. BRCA1 immunohistochemical staining as a prognostic indicator in uterine serous carcinoma.
- Author
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Beirne JP, Quinn JE, Maxwell P, Kalloger SE, McAlpine J, Gilks CB, Harley IJ, and McCluggage WG
- Subjects
- Aged, Aged, 80 and over, BRCA1 Protein analysis, Biomarkers, Tumor analysis, Biomarkers, Tumor metabolism, Cohort Studies, Cystadenocarcinoma, Serous metabolism, Cystadenocarcinoma, Serous mortality, Cystadenocarcinoma, Serous pathology, Female, Humans, Immunohistochemistry methods, Middle Aged, Prognosis, Staining and Labeling methods, Survival Analysis, Tissue Array Analysis, Uterine Neoplasms metabolism, Uterine Neoplasms mortality, Uterine Neoplasms pathology, BRCA1 Protein metabolism, Cystadenocarcinoma, Serous diagnosis, Uterine Neoplasms diagnosis
- Abstract
Objectives: The objective of this study was to investigate the relationship between BRCA1 protein expression, as determined by immunohistochemistry, and clinical outcome in uterine serous carcinoma (USC)., Methods: A tissue microarray containing duplicate cores of 73 cases of USC was immunohistochemically stained with mouse anti-BRCA1 (Ab-1) mouse monoclonal (MS110) antibody. The cores were scored in a semiquantitative manner evaluating both the distribution and intensity of nuclear staining. BRCA1 protein expression was correlated with progression-free survival., Results: Seventy-two of 73 cases were assessable, and there was a statistically significant decreased progression-free survival for those cases exhibiting tumor cell nuclei staining of 76% or greater (P = 0.0023)., Conclusions: Our study illustrates that a low level of BRCA1 protein expression is a favorable prognostic indicator in USC, similar to what is observed in high-grade serous ovarian carcinoma. Further studies should focus on the BRCA1 status of USCs at a molecular level and also investigate whether BRCA1 protein expression is associated with response to chemotherapy in USC.
- Published
- 2013
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