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Your search keyword '"3,4-dihydropyrimidinone"' showing total 4 results
Start Over Descriptor "3,4-dihydropyrimidinone" Topic urea
4 results on '"3,4-dihydropyrimidinone"'

1. Microwave-assisted multicomponent reaction for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones and their corresponding 2(1H)-thiones using lanthanum oxide as a catalyst under solvent-free conditions

Author

M. Gopalakrishnan, S. Pazhamalai, and A. Kuraitheerthakumaran

Subjects
Chemistry(all), General Chemical Engineering, Biginelli reaction, Inorganic chemistry, 010402 general chemistry, 01 natural sciences, Catalysis, lcsh:Chemistry, chemistry.chemical_compound, Lanthanum oxide, Irradiation, Solvent-free, 010405 organic chemistry, 3,4-Dihydropyrimidinone, General Chemistry, 0104 chemical sciences, Solvent, lcsh:QD1-999, Thiourea, chemistry, Chemical Engineering(all), Urea, Microwave
Abstract

An efficient synthesis of 3,4-dihydropyrimidinone derivatives using lanthanum oxide as a catalyst, from aldehydes, β-keto ester and urea/thiourea without solvent under the irradiation of microwave is described. Compared with classical Biginelli reaction conditions, this new method has the advantage of excellent yields and shorter reaction times.

Published
2016

2. Ethyl 6-Methyl-2-oxo-4-{4-[(1-phenyl-1H-1,2,3-triazol-4-yl)methoxy]phenyl}-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Author

Gustavo Machado das Neves, Itamar Luís Gonçalves, Luciano Porto Kagami, Guilherme Arraché Gonçalves, Gabriel Oliveira de Azambuja, Leonardo Davi, João Pedro Silveira, Vera Lucia Eifler-Lima, and Rômulo Faria Santos Canto

Subjects
chemistry.chemical_classification, 3,4-dihydropyrimidinone, 010405 organic chemistry, Organic Chemistry, Biginelli reaction, Triazole, LaSOM® 293, 010402 general chemistry, 01 natural sciences, Biochemistry, Aldehyde, Medicinal chemistry, lcsh:QD146-197, Cycloaddition, 0104 chemical sciences, triazole, chemistry.chemical_compound, chemistry, Yield (chemistry), lcsh:Inorganic chemistry, Urea, Carboxylate, Physical and Theoretical Chemistry, Methylene
Abstract

The Biginelli reaction is an acid-catalyzed, three-component reaction between an aldehyde, a hydrogen methylene active compound, and urea (or its analogue) and constitutes a rapid and easy synthesis of highly functionalized heterocycles. Synthesis of ethyl 6-methyl-2-oxo-4-{4-[(1-phenyl-1H-1,2,3-triazol-4-yl)methoxy]phenyl}-1,2,3,4-tetrahydropyrimidine-5-carboxylate, identified by our laboratory code LaSOM® 293, was achieved using the Biginelli reaction as the key step, followed by the Huisgen 1,3-dipolar cycloaddition in a convergent four-step route. The product LaSOM® 293 was obtained with a yield of 84%.

Published
2019

3. Phenylboronic acid as a mild and efficient catalyst for Biginelli reaction

Author

Debache, Abdelmadjid, Boumoud, Boudjemaa, Amimour, Mouna, Belfaitah, Ali, Rhouati, Salah, and Carboni, Bertrand

Subjects
*UREA, *ORGANIC compounds, *NITROGEN excretion, *URINE
Abstract

Abstract: The synthesis of 3,4-dihydropyrimidinone derivatives was achieved in good to excellent yields using phenylboronic acid as catalyst to promote the Biginelli three-component condensation of a diversity of aromatic aldehydes, ethyl acetoacetate and urea or thiourea. [Copyright &y& Elsevier]

Published
2006
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4. Ethyl 6-Methyl-2-oxo-4-{4-[(1-phenyl-1H-1,2,3-triazol-4-yl)methoxy]phenyl}-1,2,3,4-tetrahydropyrimidine-5-carboxylate.

Author

Gonçalves, Itamar Luís, Oliveira de Azambuja, Gabriel, Davi, Leonardo, Arraché Gonçalves, Guilherme, Porto Kagami, Luciano, Machado das Neves, Gustavo, Silveira, João Pedro, Faria Santos Canto, Rômulo, and Eifler-Lima, Vera Lucia

Subjects
*CARBENES, *ATOMIC hydrogen, *ALDEHYDES, *RING formation (Chemistry), *UREA, *TETRAHYDROISOQUINOLINES, *METHOXY compounds
Abstract

The Biginelli reaction is an acid-catalyzed, three-component reaction between an aldehyde, a hydrogen methylene active compound, and urea (or its analogue) and constitutes a rapid and easy synthesis of highly functionalized heterocycles. Synthesis of ethyl 6-methyl-2-oxo-4-{4-[(1-phenyl-1H-1,2,3-triazol-4-yl)methoxy]phenyl}-1,2,3,4-tetrahydropyrimidine-5-carboxylate, identified by our laboratory code LaSOM® 293, was achieved using the Biginelli reaction as the key step, followed by the Huisgen 1,3-dipolar cycloaddition in a convergent four-step route. The product LaSOM® 293 was obtained with a yield of 84%. [ABSTRACT FROM AUTHOR]

Published
2019
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