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This paper examines potential associations of loneliness with laboratory data and specific psychosocial and behavioral attitudes. The sample collection took place in an urban Primary Health Care unit between May and July 2023, consecutively, and once exclusion criteria were implemented. Participants were aged between 40 and 75 years. Routine laboratory test results upon study initiation and six months before were used. The University of California, Los Angeles (UCLA), Loneliness Scale (Version 3), blood glucose, serum lipids, Fibrosis-4 index, and Creatinine Clearance (CrCl) were assessed through hierarchical multiple logistic regression analysis. Based on full model (3rd) analysis, those who were engaged in an individual sport or activity or had contacts with more friends presented significantly lower odds for increased loneliness levels (odds ratio (OR): 0.28 [95% confidence interval (CI) 0.09–0.91], p = 0.034 and OR: 0.76 [95%CI 0.66–0.88], p < 0.001, respectively). The consumption of alcohol was associated with increased loneliness (OR: 5.55 [95%CI 1.42–21.63], p = 0.014). Elevated triglyceride levels were linked with moderate or no loneliness (OR: 0.20 [95%CI 0.05–0.83], p = 0.026), while an increased LDL/HDL atherosclerotic index was related to increased subjective loneliness (OR: 4.50 [95%CI 1.12–18.13], p = 0.035). The need for holistic approaches—involving primary care personnel—in understanding and addressing loneliness, recognizing its multifaceted nature as well as the diverse factors that contribute to this issue, is considered challenging. [ABSTRACT FROM AUTHOR]

Introduction: Due to the pandemic, individuals with ADHD have been facing noticeable challenges in their daily life. Prolonged quarantine and isolation may contribute to higher affective and PTSD symptoms among college students with ADHD. Aims: The study aimed to explore the impact of COVID-19 on affective symptoms such as depression, anxiety, stress, along with loneliness and post-traumatic stress on college students at risk for ADHD in Greece during the second COVID-19 lockdown in November 2020. Methods: A sample of 362 students completed an online survey consisting of demographic questions and four instruments: the ADHD Self-Report Scale-V1.1 (ASRS-V1.1), the DASS-21, the UCLA Loneliness Scale, and the PTSD checklist (PCL-5). Results: Over 18% of the students met the criteria for being at risk of ADHD, which is higher than in other studies conducted prior to the pandemic. Students at risk for ADHD reported significantly higher (p < .05) mean scores on all scales: depression, anxiety, stress, loneliness, and posttraumatic stress. A model to predict at-risk ADHD diagnosis indicated those who presented symptoms of depression, had low GPA, who were employed, were 46% more likely to struggle with ADHD. Conclusions: This study indicates that the pandemic may have adversely affected individuals at risk for ADHD. Recommendations for further. [ABSTRACT FROM AUTHOR]