Rising concern about the quality of medical care and preventable medical errors has increased interest in how systems of care operate. Health care organizations can shape the quality of care through the selection of clinical staff or educational programs for patients. Influencing clinician behavior, however, is arguably the most important way in which organizations affect care (Flood 1994; Landon, Wilson, and Cleary 1998). Organizations can influence clinicians using financial incentives, management strategies (e.g., utilization review, guidelines, profiling), structural arrangements (e.g., presence of particular facilities or domains of expertise, governance structures), and normative practice styles or organizational cultures. Studies of organizational influences on the quality of care require measures of organizational characteristics that are rarely, if ever, recorded in a standardized way. Organizational data are commonly collected by surveying informants about their organizations. Surveys often ask for factual data such as the number of FTE medical staff or whether professionals with particular specialties are on site. They can also ask about subjective phenomena, such as an organization's culture or mission. Recent examples include Kralewski et al. (2000), who gathered data on revenue sources and methods of physician compensation from clinic medical directors or administrators, and Meterko, Mohr, and Young (2004), who measured hospital culture by surveying hospital employees. Lazarsfeld and Menzel (1980) distinguish “global” and “analytical” organizational survey measures. Global measures refer to organization-level properties such as size or centralization of decision making. “Analytical” measures are organization-level averages of respondent-level data, such as the proportion of clinicians who are board certified in infectious diseases. High reliability is necessary but not sufficient for the validity of measurement (Bohrnstedt 1983). Imprecise measurement (low reliability) will sometimes lead investigators to incorrect conclusions about relationships between an organizational factor and outcome measures of interest. Nonetheless, few organizational studies examine the reliability of informant reports. If informant reliability is low, relying on a single informant per organization may be unwise. Just as using multiple-item scales can improve respondent-level survey measures, combining reports from multiple informants may raise reliability for organizational measurements. Assessing measure reliability can offer guidance about the number of informants needed to adequately measure different organizational properties. When organizations are the objects of measurement, studies usually can select among several possible informants, so researchers must decide which informants to approach. Standard advice is to seek out informants who are knowledgeable, motivated, and unbiased (Huber and Power 1985). Managerial or administrative informants are often chosen on the assumption that they have good access to information. Such informants, however, also may tend to present the organization positively (Seidler 1974). Studies rarely examine differences in descriptions of an organization between types of informants (e.g., medical directors and physicians). This article addresses issues of measure reliability and differences across informant types using data from a national study of medical clinics, the Evaluation of Quality Improvement for HIV (EQHIV) study. That study gathered data about clinic characteristics from the clinic director and several clinicians in each practice studied. It asked about implementation and assessment of improvement initiatives, HIV care priorities, and barriers to improvement. We examine the reliability of single-informant organizational measures based on individual survey items as well as multiple-item scales, and how reliability can be improved by using multiple informants. We also calculate the number of informants required to obtain reliable organization-level measures, and assess clinician–director differences in descriptions of a clinic.