1. Gout in Older Adults: The Atherosclerosis Risk in Communities Study
- Author
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Anna Köttgen, Alan N. Baer, Bridget Teevan Burke, Josef Coresh, Morgan E. Grams, Andrew Law, and Mara A. McAdams-DeMarco
- Subjects
Male ,Aging ,medicine.medical_specialty ,Gout ,Population ,Glucose Transport Proteins, Facilitative ,Polymorphism, Single Nucleotide ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,Surveys and Questionnaires ,Internal medicine ,Prevalence ,ATP Binding Cassette Transporter, Subfamily G, Member 2 ,Humans ,Medicine ,Cumulative incidence ,Prospective Studies ,030212 general & internal medicine ,education ,Aged ,030203 arthritis & rheumatology ,education.field_of_study ,business.industry ,Proportional hazards model ,Incidence ,Incidence (epidemiology) ,Hazard ratio ,Age Factors ,Middle Aged ,Atherosclerosis ,medicine.disease ,United States ,Middle age ,Neoplasm Proteins ,Uric Acid ,Endocrinology ,Cohort ,ATP-Binding Cassette Transporters ,Female ,Geriatrics and Gerontology ,business ,Research Article - Abstract
Background It is unclear whether traditional and genetic risk factors in middle age predict the onset of gout in older age. Methods We studied the incidence of gout in older adults using the Atherosclerosis Risk in Communities study, a prospective U.S. population-based cohort of middle-aged adults enrolled between 1987 and 1989 with ongoing follow-up. A genetic urate score was formed from common urate-associated single nucleotide polymorphisms for eight genes. The adjusted hazard ratio and 95% confidence interval of incident gout by traditional and genetic risk factors in middle age were estimated using a Cox proportional hazards model. Results The cumulative incidence from middle age to age 65 was 8.6% in men and 2.5% in women; by age 75 the cumulative incidence was 11.8% and 5.0%. In middle age, increased adiposity, beer intake, protein intake, smoking status, hypertension, diuretic use, and kidney function (but not sex) were associated with an increased gout risk in older age. In addition, a 100 µmol/L increase in genetic urate score was associated with a 3.29-fold (95% confidence interval: 1.63-6.63) increased gout risk in older age. Conclusions These findings suggest that traditional and genetic risk factors in middle age may be useful for identifying those at risk of gout in older age. more...
- Published
- 2015
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