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Objectives: The objectives of this study were to observe the Efficacy of unani pharmacopoeial formulation Boozidan (Pyrethrum indicum) for the management of Niqris Muzmin (Chronic gout) and to observe any concomitant and adverse effects of formulation. Methods: This single blind, randomized and standard control clinical study was conducted between April 2021 to October 2021 for a period of 28 days. 60 patients diagnosed with chronic gout were divided into two groups, 30 Test group and 30 Control group. The test group was administered with 5g boozidaan in powder form once daily with water and the patients of control group were given tablet febuxostat 80mg once daily. Patients were followed up and improvements in subjective parameters were assessed weekly at 7th, 14th, 21st, and 29th day. Objective parameters were assessed at the baseline and at 29th day. The data obtained was subjected to statistical analysis. Results: Both the test and control drug were effective in reducing Serum uric acid level, ESR and CRP levels. A significant improvement in subjective and objective parameters was observed in both test and control groups and no adverse effects were observed during and after the study. However, the test drug had superior efficacy in reducing the objective parameters and it was statistically significant (p-value<0.0001). Conclusion: Both Boozidaan and Febuxostat were safe and significantly effective in resolving the symptoms and signs of gouty arthritis and both have significant effect on reducing serum uric acid level. [ABSTRACT FROM AUTHOR]

Neem is very important medicinal plant which is used to treat different diseases in Unani System of Medicine as well as traditional system of medicine (Ayurveda, Homeopathic Chines and European "Materia Medica"). The use of traditional medicine and medicinal plants in most developing countries, as a normative basis for the maintenance of good health, has been widely observed. In the last century, approximately 130 pharmaceutical products have been discovered based on the information obtained from the traditional scientist and physician. The importance of the Neem tree has been recognized by the US National Academy of Sciences, which publish a report in 1992 entitled 'Neem- a tree for solving global problems'. The scientific name of Neem, Azadirachta indica, is derived from the Persian, Azad means "Free" dirakht means "tree" I-Hindi means "of Indian Origin" .Hence it literally means "the free tree of India". The Chemical principles from natural sources have become much simpler and have contributed significantly to the development of new drugs from medicinal plants and because of these facts the domain market for plant derived chemicals, pharmaceuticals, fragrances, flavor's, and color ingredients, alone exceeds several billion dollars per year. The present review highlights a Unani medicine literature as well as scientific on taxonomical, botanical, and pharmacological discussion on Neem. [ABSTRACT FROM AUTHOR]