1. Potential anti-ageing effects of probiotic-derived conditioned media on human skin cells.
- Author
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Hong YK, An S, Lee YH, Yang SA, Yoon YK, Lee J, Lee G, Chung MJ, and Bae S
- Subjects
- Humans, Culture Media, Conditioned pharmacology, Culture Media, Conditioned metabolism, Skin, Aging, Ultraviolet Rays adverse effects, Probiotics pharmacology
- Abstract
In this study, the protective functions of bacteria-free conditioned media from Bifidobacterium and Lactobacillus species against ultraviolet radiation-induced skin ageing and associated cellular damage were investigated. The effects of ultraviolet radiation-induced reactive oxygen species production were suppressed by all conditioned media; particularly, the loss of cell viability and downregulation of collagen gene expression were significantly reversed by the conditioned media from B. longum and B. lactis . Further exa mination of potential anti-pigmentation effects revealed that the B. lactis -derived conditioned media significantly inhibited tyrosinase activity and alpha-melanocyte-stimulating hormone-induced melanin production in human epidermal melanocytes. Further, the conditioned media suppressed the phosphorylation of extracellular signal- related kinase, which functions as an upstream regulator of melanogenesis. Therefore, B. lactis -derived conditioned media can potentially protect against cellular damage involved in skin-ageing processes., (© 2022 Yoo Kyung Hong et al., published by Sciendo.)
- Published
- 2022
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