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Temperature estimation is a fundamental step in assessment of the efficacy of thermal therapy. A thermochromic material sensitive within the temperature range 52.5°C-75°C has been developed. The material is based on polyvinyl alcohol cryogel with the addition of a commercial thermochromic ink. It is simple to manufacture, low cost, non-toxic and versatile. The thermal response of the material was evaluated using multiple methods, including immersion in a temperature-controlled water bath, a temperature-controlled heated needle and high-intensity focused ultrasound (HIFU) sonication. Changes in colour were evaluated using both RGB (red, green, blue) maps and pixel intensities. Acoustic and thermal properties of the material were measured. Thermo-acoustic simulations were run with an open-source software, and results were compared with the HIFU experiments, showing good agreement. The material has good potential for the development of ultrasound therapy phantoms.

Ultrasound computed tomography offers to be a transformative breast imaging technology; however, quantitative measurement and artefact-free reconstruction of the diagnostically important property of acoustic attenuation has proven to be a challenge. The UK’s National Physical Laboratory (Teddington, UK) have developed a prototype ultrasound computed tomography system which utilises a novel sensor technology specifically designed for quantitative acoustic attenuation tomography. This scanning system, with its phase-insensitive receiver, has been used to generate 2D and 3D quantitative images of the acoustic attenuation of commercially-available and bespoke breast phantoms made by CIRS (Norfolk, VA, USA). The acoustic attenuation measurements and images obtained from the system were evaluated in comparison to acoustically characterised phantom materials and Xray computed tomography imagery. The images, while generated using a relatively fast and simple reconstruction method, were found to be less susceptible to artefacts common to acoustic attenuation tomography.

Tissue mimicking materials (TMMs), typically contained within phantoms, have been used for many decades in both imaging and therapeutic applications. This review investigates the specifications that are typically being used in development of the latest TMMs. The imaging modalities that have been investigated focus around CT, mammography, SPECT, PET, MRI and ultrasound. Therapeutic applications discussed within the review include radiotherapy, thermal therapy and surgical applications. A number of modalities were not reviewed including optical spectroscopy, optical imaging and planar x-rays. The emergence of image guided interventions and multimodality imaging have placed an increasing demand on the number of specifications on the latest TMMs. Material specification standards are available in some imaging areas such as ultrasound. It is recommended that this should be replicated for other imaging and therapeutic modalities. Materials used within phantoms have been reviewed for a series of imaging and therapeutic applications with the potential to become a testbed for cross-fertilization of materials across modalities. Deformation, texture, multimodality imaging and perfusion are common themes that are currently under development.

With a number of cavitation meters on the market which claim to characterise fields in ultrasonic cleaning baths, this paper provides an objective comparison of a selection of these devices and establishes the extent to which their claims are met. The National Physical Laboratory’s multi-frequency ultrasonic reference vessel provided the stable 21.06 kHz field, above and below the inertial cavitation threshold, as a test bed for the sensor comparison. Measurements from these devices were evaluated in relation to the known acoustic pressure distribution in the cavitating vessel as a means of identifying the mode of operation of the sensors and to examine the particular indicator of cavitation activity which they deliver. Through the comparison with megahertz filtered acoustic signals generated by inertial cavitation, it was determined that the majority of the cavitation meters used in this study responded to acoustic pressure generated by the direct applied acoustic field and therefore tended to overestimate the occurrence of cavitation within the vessel, giving non-zero responses under conditions when there was known to be no inertial cavitation occurring with the reference vessel. This has implications for interpreting the data they provide in user applications.

An algorithm was developed for the correction of ring artifacts in phase-insensitive ultrasound computed tomography attenuation images. Differences in the measurement sensitivity between the ultrasound transducer array elements cause discontinuities in the sinogram which manifest as rings and arcs in the reconstructed image. The magnitudes of the discontinuities are potentially time-varying and dependent on the attenuation being measured. The algorithm dynamically determines the measurement sensitivity of each transducer in the array during the scan by comparison with both the elements to its left and the elements to its right. Elements at either end of the array are corrected, assuming a zero-attenuation path. The two estimates of sensitivity are combined using a weighted mean similar to a Kalman filter. The algorithm was tested on simulated and experimentally acquired data. It was demonstrated to reduce the root-mean-square error (RMSE) of simulated images against ground-truth images by up to a factor of 50 compared with uncorrected images and to visibly reduce artifacts on images reconstructed from the experimentally acquired data.

Phantom test devices are used in the development of medical imaging modalities to gain a more complete understanding of the underlying physical processes and to optimize techniques. There are currently no standard photoacoustic imaging (PAI) phantoms, although there is a move towards standardization, notably in a new international consortium (IPASC) focusing on the standardization of PAI techniques and phantoms. The use of gel wax/copolymer in oil materials in PAI is relatively recent with only limited studies carried out, however such materials hold promise for wide-spread adoption as a phantom material due to ease of preparation and extensive component availability. A standardized preparation method for the material has yet to be published. This work describes an investigation of the acoustic properties of various preparations of the bulk material. The final material consisted of 84.49 % mineral oil (light), 12 % Polystyrene-block-poly(ethylene-ran-butylene)-block-polystyrene 3 % low density polyethylene, 0.05 % TiO2 and 0.46 % Benzalkonium chloride and had stable acoustic properties mimicking fatty soft tissue over 6 months, with a phase velocity of 1464.2 ± 0.4 m s‒1 and mean attenuation of 4.04 ± 0.2 dB cm‒1 at 5 MHz.

Ultrasound is typically measured using phase-sensitive piezoelectric sensors. Interest in phase-insensitive sensors has grown recently, with proposed applications including ultrasound attenuation tomography of the breast and acoustic power measurement. One advantage of phase-insensitive detectors, in contrast to conventional phase-sensitive detectors, is that they do not suffer from a narrow directional response at high frequencies due to phase cancellation. A numerical model of a phase-insensitive pyroelectric ultrasound sensor is presented. The model consists of three coupled components run in sequence: acoustic, thermal, and electrical. The acoustic simulation models the propagation and absorption of the incident ultrasound wave. The absorbed acoustic power density is used as a heat source in the thermal simulation of the time-evolution of the temperature in the sensor. Both the acoustic and thermal simulations are performed using the k-Wave MATLAB toolbox with an assumption that shear waves are not supported in the medium. The final component of the model is a pyroelectric circuit model which outputs the sensor response based on the temperature change in the sensor. The modelled pyroelectric sensor response and directional dependence are compared to empirical data.

A multi-frequency cavitation vessel (RV-multi) has been commissioned at the National Physical Laboratory (NPL, UK), with the aim of establishing a standard source of acoustic cavitation in water, with reference to which details of the cavitation process can be studied and cavitation measurement techniques evaluated. The vessel is a cylindrical cavity with a maximum capacity up to 17 L, and is designed to work at six frequency ranges, from 21 kHz to 136 kHz, under controlled temperature conditions. This paper discusses the design of RV-multi and reports experiments carried out to establish the reproducibility of the acoustic pressure field established within the vessel and its operating envelope, including sensitivity to aspects such as water depth and temperature. The acoustic field distribution was determined along the radial and depth directions within the vessel using a miniature hydrophone, for two input voltage levels under low power transducer excitation conditions (e.g. below the cavitation threshold). Particular care was taken in determining peak acoustic pressure locations, as these are critical for accompanying cavitation studies. Perturbations of the vessel by the measuring hydrophone were also monitored with a bottom-mounted pressure sensor.

Ultrasound is typically measured using phase-sensitive piezoelectric sensors. Interest in phase-insensitive sensors has grown recently, with proposed applications in ultrasound attenuation tomography of the breast. The advantage of phase-insensitive imaging is that it does not suffer from degradation of image quality due to phase-aberration and narrow directional response. A numerical model of a phase-insensitive pyroelectric ultrasound sensor is presented. The model consists of three coupled components run in sequence: acoustic, thermal, and electrical. The acoustic simulation models the propagation and absorption of the incoming ultrasound wave. The negative divergence of the time-averaged acoustic intensity is used as a heat source in the thermal simulation for the time-evolution of temperature in the sensor. Both the acoustic and thermal simulations are performed using the k-Wave MATLAB toolbox with an assumption that shear waves are not supported in the medium. The final component of the model uses a pyroelectric circuit model which outputs the sensor response based on the temperature change in the sensor. The modelled pyroelectric sensor response and directional dependence are compared to empirical data. A physical model for the directionality of the sensor response is then proposed.

The ability to accurately quantify chromophore concentration from photoacoustic images would have a major impact on pre-clinical and clinical imaging. Recent years have seen significant advances in the theoretical understanding of quantitative photoacoustic imaging and in the development of model-based inversion strategies that overcome issues such as non-uniqueness and non-linearity. Nevertheless, their full in vivo implementation has not successfully been achieved, partially because experimental uncertainties complicate the transition. In this study, a sensitivity analysis is performed to assess the impact on accuracy of having uncertainty in critical experimental parameters such as scattering, beam diameter, beam position and calibration factor. This study was performed using two virtual phantoms, at one illumination and four optical wavelengths. The model-based inversion was applied in 3 variants - one just inverting for chromophores and two others further inverting for either a scaling factor or the scatterer concentration. The performance of these model-based inversions is also compared to linear unmixing strategies - with and without fluence correction. The results show that experimental uncertainties in a priori fixed parameters - especially calibration factor and scatterer concentration - significantly affect accuracy of model-based inversions and therefore measures to ameliorate this uncertainty should be considered. Including a scaling parameter in the inversion appears to improve quantification estimates. Furthermore, even with realistic levels of experimental uncertainty in model-based input parameters, they outperform linear unmixing approaches. If parameter uncertainty is large and has significant impact on accuracy, the parameter can be included as an unknown in model-based schemes.

A systematic study of the application of a novel pyroelectric technique to the measurement of diagnostic-level medical ultrasound output power is described. The method exploits the pyroelectric properties of a 0.028 mm thick membrane of polyvinylidene fluoride (PVDF), backed by an acoustic absorber whose ultrasonic absorption coefficient approaches 1000 dB cm−1 at 3 MHz. When exposed to an ultrasonic field, absorption of ultrasound adjacent to the PVDF–absorber interface results in heating and the generation of a pyroelectric output voltage across gold electrodes deposited on the membrane. For a sensor large enough to intercept the whole of the acoustic beam, the output voltage can be calibrated for the measurement of acoustic output power. A number of key performance properties of the method have been investigated. The technique is very sensitive, with a power to voltage conversion factor of typically 0.23 V W−1. The frequency response of a particular embodiment of the sensor in which acoustic power reflected at the absorber–PVDF interface is subsequently returned to the pyroelectric membrane to be absorbed, has been evaluated over the frequency range 1.5 MHz to 10 MHz. This has shown the frequency response to be flat to within ±4%, above 2.5 MHz. Below this frequency, the sensitivity falls by 20% at 1.5 MHz. Linearity of the technique has been demonstrated to within ±1.6% for applied acoustic power levels from 1 mW up to 120 mW. A number of other studies targeted at assessing the achievable measurement uncertainties are presented. These involve: the effects of soaking, the influence of the angle of incidence of the acoustic beam, measurement repeatability and sensitivity to transducer positioning. Additionally, over the range 20 °C to 30 °C, the rate of change in sensitivity with ambient temperature has been shown to be +0.5% °C−1. Implications of the work for the development of a sensitive, traceable, portable, secondary method of ultrasound output power measurement, appropriate for clinical diagnostic ultrasound systems, are discussed.

The last 25 years has seen a number of significant developments in the establishment of a measurement infrastructure supporting medical applications of ultrasound. This has allowed manufacturers and users of medical ultrasonic equipment to undertake and compare measurements of key parameters describing the magnitude or strength of the applied ultrasonic field in a meaningful and traceable way: for equipment development, standards compliance, and quality assurance purposes. This paper describes the current state of the art for measurement techniques used to determine the key properties of an ultrasonic field, principally acoustic pressure and acoustic power. Measurement tools and methodologies are described in detail, alongside considerations of how these are likely to develop, shaped by user need. The way that these measurement methods underpin a range of international and national specification standards enabling equipment manufacturers to demonstrate that their equipment is safe and fit for purpose is covered.

As part of an ongoing project to establish a reference facility for acoustic cavitation at the National Physical Laboratory (NPL), carefully controlled studies on a 25 kHz, 1.8 kW cylindrical vessel are described. Using a patented high-frequency acoustic emission detection method and a sonar hydrophone, results are presented of the spatial variation of inertial acoustic cavitation with increasing peak-negative pressure. Results show that at low operating levels, inertial acoustic cavitation is restricted to, and is strongly localized on, the vessel axis. At intermediate power settings, inertial acoustic cavitation also occurs close to the vessel walls, and at higher settings, a complex spatial variation is seen that is not apparent in measurements of the 25 kHz driving field alone. At selected vessel locations, a systematic investigation of the inertial cavitation threshold is described. This was carried out by making simultaneous measurements of the peak-negative pressures leading to inertial cavitation and the resultant MHz-frequency emissions, and indicates an inertial cavitation threshold of 101 kPa plusmn 14% (estimated expanded uncertainty). However, an intermediate threshold at 84 kPa plusmn 14% (estimated expanded uncertainty) is also seen. The results are discussed alongside theoretical predictions and recent experimental findings.

Ultrasound (US) physiotherapy as a clinical treatment is extremely common in the Western world. Internationally, regulation to ensure safe application of US physiotherapy by regular calibration ranges from nil to mandatory. The need for a portable power standard (PPS) has been addressed within a European Community (EC)-funded project. This PPS consists of an electrical driver, a set of US transducers and a cavitation detector (CD). Each component has been extensively tested for stability and travel robustness. Transducer output power has been determined with an uncertainty of 100%). The PPS is now ready to be used to underpin traceable calibration of physiotherapy devices. (E-mail: rt.hekkenberg@pg.tno.nl). © 2006 World Federation for Ultrasound in Medicine & Biology.

Physical therapy ultrasound is widely applied to patients. However, many devices do not comply with the relevant standard stating that the actual power output shall be within ±20% of the device indication. Extreme cases have been reported: from delivering effectively no ultrasound or operating at maximum power at all powers indicated. This can potentially lead to patient injury as well as mistreatment. The present European (EC) project is an ongoing attempt to improve the quality of the treatment of patients being treated with ultrasonic physical-therapy. A Portable ultrasound Power Standard (PPS) is being developed and accurately calibrated. The PPS includes: Ultrasound transducers (including one exhibiting an unusual output) and a driver for the ultrasound transducers that has calibration and proficiency test functions. Also included with the PPS is a Cavitation Detector to determine the onset of cavitation occurring within the propagation medium. The PPS will be suitable for conducting in-the-field accreditation (proficiency testing and calibration). In order to be accredited it will be important to be able to show traceability of the calibration, the calibration process and qualification of testing staff. The clinical user will benefit from traceability because treatments will be performed more reliably.

Cavitation monitoring is desired to optimize the sonication for diverse sonochemical processes and to detect changes or malfunctions during operation. In situ cavitation measurements can be carried out by detection of the acoustic emissions of cavitation bubbles by sensors in the liquid. However, in harsh environments sensors might not be applicable. Thus, the impact of cavitation on the electrical signals of a piezoelectric transducer has been analyzed as alternative method to measure the threshold, strength and type of cavitation. The applicability has been tested in three different setups to evaluate the generalizability of extracted indicators.

To support the development of clinical applications of high-frequency ultrasound, appropriate tissue-mimicking materials (TMMs) are required whose acoustic properties have been measured using validated techniques. This paper describes the characterisation of the sound speed (phase velocity) and attenuation coefficient of the International Electrotechnical Commission (IEC) agar-based TMM over the frequency range 1 to 60 MHz. Measurements implemented a broadband through-transmission substitution immersion technique over two overlapping frequency ranges, with co-axially aligned 50 MHz centre-frequency transducers employed for characterisation above 15 MHz. In keeping with usual practice employed within the technical literature, thin acoustic windows (membranes) made of 12-μm-thick Mylar protected the TMM from water damage. Various important sources of uncertainty that could compromise measurement accuracy have been identified and evaluated through a combination of experimental studies and modelling. These include TMM sample thickness, measured both manually and acoustically, and the influence of interfacial losses that, even for thin protective membranes, are significant at the frequencies of interest. In agreement with previous reports, the attenuation coefficient of the IEC TMM exhibited non-linear frequency dependence, particularly above 20 MHz, yielding a value of 0.93 ± 0.04 dB cm(-1) MHz(-1) at 60 MHz, derived at 21 ± 0.5°C. For the first time, phase velocity, measured with an estimated uncertainty of ±3.1 m s(-1), has been found to be dispersive over this extended frequency range, increasing from 1541 m s(-1) at 1 MHz to 1547 m s(-1) at 60 MHz. This work will help standardise acoustic property measurements, and establishes a reference measurement capability for TMMs underpinning clinical applications at elevated frequencies.

Significant nonuniformities in the acoustic intensity distribution generated by physiotherapy ultrasound treatment heads are not uncommon, potentially leading to significant localised temperature rises and tissue damage. An acoustic absorber tile containing a thermochromic pigment has been developed to provide rapid quality assurance of physiotherapy ultrasound treatment heads by virtue of a thermochromic colour change, indicating the time-averaged intensity distributions generated by these devices. As a bench-top device, the use of the tile is designed to mimic the nature of the physiotherapeutic application, requiring minimal training. Two designs where thermochromic pigments are added to the various polymeric layers of the tile are presented. Testing has been conducted with two physiotherapy treatment heads of differing performance, one of them notably exhibiting a strong “hot-spot” in localised acoustic time-averaged intensity. Findings show good qualitative agreement with classical hydrophone scans. Techniques are explored for the correction of nonlinearities in the thermochromic relationship, to enhance the accuracy of quantitative assessment.

This article presents results for the prediction of in situ exposure levels using a new experimental technique based on the use of acoustical attenuators. These are made of low-density polyethylene and are placed in the ultrasound beam between the transducer face and the measuring hydrophone. The method has been tested for a number of different ultrasonic fields including those generated by diagnostic medical ultrasonic equipment. Using a tissue-mimicking material as a reference, it is shown that it is possible to use this new method to simulate acoustic pressure levels to within ±10% and acoustic intensity and power levels within ±20%. The method is proposed as the basis for a standard test method with wide applicability.

The prediction of the acoustic levels occurring in a patient during ultrasound examination is important for the assessment of equipment safety. While considerable effort has been devoted to theoretical methods of predicting exposure levels, there is a need to develop simple experimental methods which are universally applicable to the wide range of ultrasonic fields generated by medical ultrasonic equipment. This article outlines a number of methods that have been proposed and explores in detail a new experimental method based on the use of acoustical attenuators, made of low-density polyethylene, which are placed in the ultrasound beam between the transducer and the measuring hydrophone. Measurements of important acoustical quantities have been made using a measurement system based on a multielement hydrophone and comparisons made between this new method and other methods such as electrical attenuation and linear derating theory. The acoustical attenuation technique has been systematically studied, and results are compared with reference levels obtained using tissuemimicking material. A procedure involving making measurements with the attenuator placed first at the face of the transducer and then at the hydrophone has been developed. By taking the mean value of these two measurements, it has been shown that this new method can simulate within ±10% the acoustic levels obtained using the reference. It is concluded that it could be the basis of a universally applicable method.

This paper describes a new concept for an ultrasonic cavitation sensor designed specifically for monitoring acoustic emissions generated by small microbubbles when driven by an applied acoustic field. Its novel features include a hollow, open-ended, cylindrical shape, with the sensor being a right circular cylinder of height 32 mm and external diameter 38 mm. The internal diameter of the sensor is 30 mm; its inner surface is fabricated from a 110 /spl mu/m layer of piezoelectrically active film whose measurement bandwidth is sufficient to enable acoustic emissions up to and beyond 10 MHz to be monitored. When in use, the sensor is immersed within the liquid test medium and high frequency (megahertz) acoustic emissions occurring within the hollow body of the sensor are monitored. In order to shield the sensor response from events occurring outside the cylinder, the outer surface of the sensor cylinder is encapsulated within a special 4 mm thick polyurethane-based cavitation shield with acoustic properties specifically developed to be minimally perturbing to the 40 kHz applied acoustic field but attenuating to ultrasound generated at megahertz frequencies (plane-wave transmission loss >30 dB at 1 MHz). This paper introduces the rationale behind the new sensor, describing details of its construction and the materials formulation program undertaken to develop the cavitation shield.

This paper describes imaging of breast phantoms using a prototype phase-insensitive ultrasound computed tomography (piUCT) system. The piUCT technique generates quantitative maps of acoustic attenuation with potential application to the detection of breast cancer. The effectiveness of the piUCT technique has been previously demonstrated in the laboratory through imaging of small, cylindrical, polyurethane phantoms. This paper presents images generated by the new system, which was designed to image breasts and breast phantoms up to 200 mm in diameter at 3.2 MHz. piUCT images are compared with XCT images and laboratory measurements of the attenuation of the constituent materials of the phantom.

Dow Corning 710 silicone fluid has been investigated to establish its suitability as a reference liquid for ultrasonic attenuation. Measurements made in the megahertz frequency range with overall uncertainties of 4–5% at a confidence level of 95% are compared with previous values given in the literature. The results of studies made to assess the long-term stability of the fluid are also presented.