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Background: This study explored the feasibility of radiofrequency (RF)-based radiomics analysis techniques for the preoperative prediction of programmed cell death protein 1 (PD-1) in patients with hepatocellular carcinoma (HCC).Methods: The RF-based radiomics analysis method used ultrasound multifeature maps calculated from the RF signals of HCC patients, including direct energy attenuation (DEA) feature map, skewness of spectrum difference (SSD) feature map, and noncentrality parameter S of the Rician distribution (NRD) feature map. From each of the above ultrasound maps, 345 high-throughput radiomics features were extracted. Then, the useful radiomics features were selected by the sparse representation method and input into support vector machine (SVM) classifier for PD-1 prediction.Results and Conclusion: Among all the RF-based prediction models and the ultrasound grayscale comparative model, the RF-based model using all of the three ultrasound feature maps had the highest prediction accuracy (ACC) and area under the curve (AUC), which were 92.5% and 94.23%, respectively. The method proposed in this paper is effective for the meaningful feature extraction of RF signals and can effectively predict PD-1 in patients with HCC. [ABSTRACT FROM AUTHOR]

Gastric cancer is the second most lethal type of malignant tumor in the world. Early diagnosis of gastric cancer can reduce the transformation to advanced cancer and improve the early treatment rate. As a cheap, real-time, non-invasive examination method, oral contrast-enhanced ultrasonography (OCUS) is a more acceptable way to diagnose gastric cancer than interventional diagnostic methods such as gastroscopy. In this paper, we proposed a new method for the diagnosis of gastric diseases by automatically analyzing the hierarchical structure of gastric wall in gastric ultrasound images, which is helpful to quantify the diagnosis information of gastric diseases and is a useful attempt for early screening of gastric cancer. We designed a gastric wall detection network based on U-net. On this basis, anisotropic diffusion technology was used to extract the layered structure of the gastric wall. A simple and useful gastric cancer screening model was obtained by calculating and counting the thickness of the five-layer structure of the gastric wall. The experimental results showed that our model can accurately identify the gastric wall, and it was found that the layered parameters of abnormal gastric wall is significantly different from that of normal gastric wall. For the screening of gastric disease, a statistical model based on gastric wall stratification can give a screening accuracy of 95% with AUC of 0.92. [ABSTRACT FROM AUTHOR]

Background: Lung ultrasound (LUS) can be an important imaging tool for the diagnosis and assessment of lung involvement. Ultrasound sonograms have been confirmed to illustrate damage to a person's lungs, which means that the correct classification and scoring of a patient's sonogram can be used to assess lung involvement.Methods: The purpose of this study was to establish a lung involvement assessment model based on deep learning. A novel multimodal channel and receptive field attention network combined with ResNeXt (MCRFNet) was proposed to classify sonograms, and the network can automatically fuse shallow features and determine the importance of different channels and respective fields. Finally, sonogram classes were transformed into scores to evaluate lung involvement from the initial diagnosis to rehabilitation.Results and Conclusion: Using multicenter and multimodal ultrasound data from 104 patients, the diagnostic model achieved 94.39% accuracy, 82.28% precision, 76.27% sensitivity, and 96.44% specificity. The lung involvement severity and the trend of COVID-19 pneumonia were evaluated quantitatively. [ABSTRACT FROM AUTHOR]

As a widely used imaging modality in the medical field, ultrasound has been applied in community medicine, rural medicine, and even telemedicine in recent years. Therefore, the development of portable ultrasound devices has become a popular research topic. However, the limited size of portable ultrasound devices usually degrades the imaging quality, which reduces the diagnostic reliability. To overcome hardware limitations and improve the image quality of portable ultrasound devices, we propose a novel generative adversarial network (GAN) model to achieve mapping between low-quality ultrasound images and corresponding high-quality images. In contrast to the traditional GAN method, our two-stage GAN that cascades a U-Net network prior to the generator as a front end is built to reconstruct the tissue structure, details, and speckle of the reconstructed image. In the training process, an ultrasound plane-wave imaging (PWI) data-based transfer learning method is introduced to facilitate convergence and to eliminate the influence of deformation caused by respiratory activities during data pair acquisition. A gradual tuning strategy is adopted to obtain better results by the PWI transfer learning process. In addition, a comprehensive loss function is presented to combine texture, structure, and perceptual features. Experiments are conducted using simulated, phantom, and clinical data. Our proposed method is compared to four other algorithms, including traditional gray-level-based methods and learning-based methods. The results confirm that the proposed approach obtains the optimum solution for improving quality and offering useful diagnostic information for portable ultrasound images. This technology is of great significance for providing universal medical care. [ABSTRACT FROM AUTHOR]

Background: To evaluate the accuracy of radiomics algorithm based on original radio frequency (ORF) signals for prospective prediction of microvascular invasion (MVI) in hepatocellular carcinoma (HCC) lesions. Methods: In this prospective study, we enrolled 42 inpatients diagnosed with HCC from January 2018 to December 2018. All HCC lesions were proved by surgical resection and histopathology results, including 21 lesions with MVI. Ultrasound ORF data and grayscale ultrasound images of HCC lesions were collected before operation for further radiomics analysis. Three ultrasound feature maps were calculated using signal analysis and processing (SAP) technology in first feature extraction. The diagnostic accuracy of model based on ORF signals was compared with the model based on grayscale ultrasound images. Results: A total of 1,050 radiomics features were extracted from ORF signals of each HCC lesion. The performance of MVI prediction model based on ORF was better than those based on grayscale ultrasound images. The best area under curve, accuracy, sensitivity, and specificity of ultrasound radiomics in prediction of MVI were 95.01, 92.86, 85.71, and 100%, respectively. Conclusions: Radiomics algorithm based on ultrasound ORF data combined with SAP technology can effectively predict MVI, which has potential clinical application value for non-invasively preoperative prediction of MVI in HCC patients. [ABSTRACT FROM AUTHOR]

Background: Ultrasound computed tomography (USCT) is usually realized with a ring array. It can provide better imaging performance and more tissue information by emitting and receiving the ultrasound signal in different directions simultaneously. However, USCT imaging is usually applied with the synthetic aperture (SA) emission method, which leads to a long scanning time with a large number of elements on the ring array. The echo image can provide the structural information, and has a higher resolution than maps of other parameters in USCT. Hence, we proposed plane wave (PW) imaging for ring array to acquire the echo wave and reduce the scanning time considerably.Results: In this paper, an emitting and receiving process was proposed to realize plane wave imaging with a ring array. With the proposed scanning method, the number of emission events can be reduced greatly. A beamforming method based on the eigenspace-based minimum variance (ESBMV) was also combined with the scanning method. With ESBMV beamformer, the resolution and contrast ratio of reconstruction result can be maintained or even improved under a fewer-emissions condition. We validated the method using both computer simulations with Field II and phantom experiments with a ring array of 512 elements. The Verasonics® system was used to transmit and receive the ultrasound signal in the phantom experiments.Conclusions: According to the results of the experiments, the imaging results will have a better contrast ratio with a higher emitting energy. Additionally, the scanning time with the proposed method can be only one-tenth of that with the SA emission method, while the echo imaging performance still remains at a similar level or even better. [ABSTRACT FROM AUTHOR]

Purpose: Due to the low contrast, blurry boundaries, and large amount of shadows in breast ultrasound (BUS) images, automatic tumor segmentation remains a challenging task. Deep learning provides a solution to this problem, since it can effectively extract representative features from lesions and the background in BUS images. Methods: A novel automatic tumor segmentation method is proposed by combining a dilated fully convolutional network (DFCN) with a phase‐based active contour (PBAC) model. The DFCN is an improved fully convolutional neural network with dilated convolution in deeper layers, fewer parameters, and batch normalization techniques; and has a large receptive field that can separate tumors from background. The predictions made by the DFCN are relatively rough due to blurry boundaries and variations in tumor sizes; thus, the PBAC model, which adds both region‐based and phase‐based energy functions, is applied to further improve segmentation results. The DFCN model is trained and tested in dataset 1 which contains 570 BUS images from 89 patients. In dataset 2, a 10‐fold support vector machine (SVM) classifier is employed to verify the diagnostic ability using 460 features extracted from the segmentation results of the proposed method. Results: Advantages of the present method were compared with three state‐of‐the‐art networks; the FCN‐8s, U‐net, and dilated residual network (DRN). Experimental results from 170 BUS images show that the proposed method had a Dice Similarity coefficient of 88.97 ± 10.01%, a Hausdorff distance (HD) of 35.54 ± 29.70 pixels, and a mean absolute deviation (MAD) of 7.67 ± 6.67 pixels, which showed the best segmentation performance. In dataset 2, the area under curve (AUC) of the 10‐fold SVM classifier was 0.795 which is similar to the classification using the manual segmentation results. Conclusions: The proposed automatic method may be sufficiently accurate, robust, and efficient for medical ultrasound applications. [ABSTRACT FROM AUTHOR]

In recent years, plane-wave imaging (PWI) has attracted considerable attention because of its high temporal resolution. However, the low spatial resolution of PWI limits its clinical applications, which has inspired various studies on the high spatial resolution reconstruction of PW ultrasound images. Although compounding methods and traditional high spatial resolution reconstruction approaches can improve the image quality, these techniques decrease the temporal resolution. Since learning methods can fully reserve the high temporal resolution of PW ultrasounds, a novel convolutional neural network (CNN) model for the high spatial–temporal resolution reconstruction of PW ultrasound images is proposed in this paper. Considering the multiangle form of PW data, a multichannel model is introduced to produce balanced training. To combine local and contextual information, the multiscale model is adopted. These two innovations constitute our multichannel and multiscale CNN (MMCNN) model. Compared with traditional CNN methods, the proposed model uses a two-stage structure in which a cascading wavelet postprocessing stage is combined with the trained MMCNN model. Cascading wavelet postprocessing aims to preserve speckle information. Furthermore, a feedback system is appended to the iteration process of the network training to solve the overfitting problem and help produce convergence. Based on these improvements, an end-to-end mapping is established between a single-angle B-mode PW image and its corresponding multiangle compounded, high-resolution image. The experiments were conducted on simulated, phantom, and real human data. The advantages of our proposed method were compared with a coherent PW compounding method, a conventional maximuma posteriori-based high spatial resolution reconstruction method, and a 2-D CNN compounding method, and the results verified that our approach is capable of attaining a better temporal resolution and comparable spatial resolution. In clinical usage, the proposed method is equipped to satisfy with many ultrafast imaging applications, which require high spatial–temporal resolution. i [ABSTRACT FROM AUTHOR]

Featured Application: This work makes real-time imaging of tumor microvessels more realistic. The emergence of super-resolution imaging makes it possible to display the microvasculatures clearly using ultrasound imaging, which is of great importance in the early diagnosis of cancer. At present, the super-resolution performance can only be achieved when the sampling signal is long enough (usually more than 10,000 frames). Thus, the imaging time resolution is not suitable for clinical use. In this paper, we proposed a novel super-resolution reconstruction method, which is proved to have a satisfactory resolution using shorter sampling signal sequences. In the microbubble localization step, the integrated form of the 2D Gaussian function is innovatively adopted for image deconvolution in our method, which enhances the accuracy of microbubble positioning. In the trajectory tracking step, for the first time the averaged shifted histogram technique is presented for the visualization, which greatly improves the precision of reconstruction. In vivo experiments on rabbits were conducted to verify the effectiveness of the proposed method. Compared to the conventional reconstruction method, our method significantly reduces the Full-Width-at-Half-Maximum (FWHM) by 50% using only 400-frame signals. Besides, there is no significant increase in the running time using the proposed method. Considering its imaging performance and used frame number, the conclusion can be drawn that the proposed method advances the application of super-resolution imaging to the clinical use with a much higher time resolution. [ABSTRACT FROM AUTHOR]

The thickness of nuchal translucency (NT) is one of the most important parameters to be detected in prenatal screening during the first trimester of pregnancy. In this paper, an automatic method is proposed for the localization of the volume of interest (VOI) of NT in three-dimensional (3D) ultrasound data. With the size and position of the fetal head and the equation of the sagittal plane in the 3D ultrasound data as the prior knowledge, the method can be divided into three steps. First, a Hessian-based plate filter is proposed to enhance the possible plates in the volume. Second, several VOIs with large filter responses are selected as candidates. Those VOIs consisting of several connected planes are segmented according to the prior knowledge of the sagittal plane. Third, a set of shape features is proposed to select the NT VOI with the maximum probability. Automatic fetal head localization and sagittal plane detection can be achieved using our previously proposed methodology, which means fully automatic NT volume detection could be reached by using our method. The proposed method produces 86.36% localization accuracy with the manual selection as the ground truth. [ABSTRACT FROM PUBLISHER]

Plane wave compounding is a useful mode for ultrasound imaging because it can make a good compromise between imaging quality and frame rate. It is also useful for broad view ultrasound imaging. Traditional coherent plane wave compounding coherently sums the echo data of different steered transmitting waves as the output. The data correlation information of different emissions is not considered. Therefore, some adaptive techniques can be introduced into the compounding procedure. In this paper, we propose a Joint Transmitting-Receiving (JTR) adaptive beamforming scheme for plane wave compounding. Unlike traditional adaptive beamformers, the proposed beamforming scheme is designed for the 2-D data set obtained from multiple plane wave firings. It calculates both the transmitting aperture weights and the receiving aperture weights and then combines them into a 2-D adaptive weight function for compounding. Experiments are conducted on both simulated and phantom data. Results show that the proposed scheme has better performance on both point targets and cysts than the existing plane wave compounding approach. Because of the adaptive process in both apertures for compounding, an improved resolution is observed in both simulation and phantom studies. When the eigenanalysis is introduced, a contrast enhancement is achieved. For the simulated cyst, a contrast ratio (CR) improvement of 48% is achieved compared with the traditional plane wave compounding. For the phantom cyst, this improvement is 213.8%. The proposed scheme also has good robustness against sound velocity errors. Therefore, it is effective in enhancing the coherent plane wave compounding quality. [ABSTRACT FROM PUBLISHER]

The nuchal translucency thickness is an important parameter for the diagnosis of fetal abnormalities during 11–14 weeks. Currently in clinical practice, it first requires manual scanning operations to determine the fetal standard sagittal-view plane and then the measurements can be performed in the corresponding plane images. Besides the difficulty of such standard plane detection, this also leads to the time-consuming and detection-variability problems. In the paper, a hierarchical model is proposed to automatically detect the standard sagittal-view plane based on 3D ultrasound data. In the model, Hessian-matrix based filtering is first applied for obtaining the plate-structure distribution in the data. Then the sphere distribution is calculated by convolving sphere detectors with the ultrasound data. Based on the two prior distributions, the sampling-based Hough transform is further performed for the plane detection. The performance of the proposed model is verified by the experimental results on 3D synthetic data and 241 clinical 3D ultrasound data in 11–14 weeks. [ABSTRACT FROM AUTHOR]

Ultrasonography has been widely used to evaluate duodenogastric reflux (DGR). But to the best of our knowledge, no automatic analysis system was developed to realize the quantitative computer-aided analysis. In this paper, we propose a system to perform the automatic detection of DGR in the ultrasonic image sequences by applying the automatic motion analysis. The motion field is estimated based on image velocimetry. Then, an intelligent motion analysis is applied. For the DGR detection, the motion and structural information is combined to analyze the transploric motion of the fluid. In order to test the performance of the proposed system, we designed the experiment with the real and synthetic ultrasonic data. The proposed system achieved a good performance in the DGR detection. The automatic results were accordant with the gold standard in analyzing the fluid motion. The proposed system is supposed to be a promising tool for the study and evaluation of DGR. [ABSTRACT FROM AUTHOR]

The eigenspace-based minimum variance (ESBMV) beamformer can provide good imaging resolution and contrast; however, the performance is achieved at the cost of high computational complexity. In adaptive array processing, the beamspace method is an efficient way to lower the computational complexity. In this paper, we combine the beamspace method with the ESBMV beamformer and propose a beamdomain ESBMV beamformer. We demonstrate the feasibility of introducing the beamspace into the ESBMV beamformer and propose an effective method of forming the transform matrix based on the spatial spectrum of the array signals. We also illustrate the performance of the proposed beamformer when resolving point scatterers and a cyst phantom with both simulated and experimental data. The results show that the proposed method can achieve performance comparable to the ESBMV beamformer within much shorter time. [ABSTRACT FROM AUTHOR]

Purpose: Assessment of the fetal cerebellar volume on 3D ultrasound data sets is very important in the clinical evaluation of the fetal growth and health. However, the irregular shape of the cerebellum and the strong artifacts of ultrasound images complicate the segmentation without manual intervention. In this paper, the authors propose an approach to locate the cerebellum automatically, which is considered as a prework of the segmentation. Methods: The authors present a weighted Hough transform and a constrained randomized Hough transform to detect the fetal brain midline and the skull, respectively. By combining the location information of these two structures with local image features, a constrained probabilistic boosting tree is then proposed to search the cerebellum. Results: This algorithm was tested on ultrasound volumes of the fetal head with the gestational age ranging from 20 to 33 weeks. Compared with manual measurements, this algorithm obtained a satisfactory performance with the mean Dice similarity coefficient of 0.92 and the average processing time of 0.75 s per case. Conclusions: The results demonstrate that the proposed method is an automatic, fast, and accurate tool for searching the fetal cerebellum on ultrasound volumes. [ABSTRACT FROM AUTHOR]

Purpose: Estimating the fluid motion in ultrasonic videos is a crucial step in the analysis of duodenogastric reflux. Severe image noise and illumination changes in the pyloric region (the region of interest) challenge the accurate estimation of gastric flow. In this paper, the authors propose an illumination-robust optical flow method based on the weighted cross-correlation. Methods: Cross-correlation was combined with the variational optical method framework as an illumination-robust local feature identifier. In consideration of accuracy near edges, they constructed visual similarity weights according to the characteristics of ultrasonic images. A processing procedure containing coarse-to-fine step and refinement was designed to get the final results. They tested the proposed method on synthetic and real ultrasonic images and compared it with other three optical flow methods. For quantitative evaluation, two metrics of angular and amplitude error were used. Results: The synthetic results demonstrate that the proposed method performs better on ultrasonic images, with angular error of 4.1° and amplitude error of 3.3%. In qualitative comparison, the proposed method kept the motion field smooth in the homogeneous region while preserving edge information. When they used the results of the proposed method to judge the gastric flow direction, the automatic judgments agreed well with visual observation. Conclusions: The proposed method is a good tool for image velocimetry in ultrasonic images. It provides promising results to estimate the motion of gastric flow in ultrasonic videos. [ABSTRACT FROM AUTHOR]

Tracking pylorus in ultrasonic image sequences is an important step in the analysis of duodenogastric reflux (DGR). We propose a joint prediction and segmentation method (JPS) which combines optical flow with active contour to track pylorus. The goal of the proposed method is to improve the pyloric tracking accuracy by taking account of not only the connection information among edge points but also the spatio-temporal information among consecutive frames. The proposed method is compared with other four tracking methods by using both synthetic and real ultrasonic image sequences. Several numerical indexes: Hausdorff distance (HD), average distance (AD), mean edge distance (MED), and edge curvature (EC) have been calculated to evaluate the performance of each method. JPS achieves the minimum distance metrics (HD, AD, and MED) and a smaller EC. The experimental results indicate that JPS gives a better tracking performance than others by the best agreement with the gold curves while keeping the smoothness of the result. [ABSTRACT FROM AUTHOR]

Abstract: An ultrasound speckle reduction method is proposed in this paper. The filter, which enhances the power of anisotropic diffusion with the Smallest Univalue Segment Assimilating Nucleus (SUSAN) edge detector, is referred to as the SUSAN-controlled anisotropic diffusion (SUSAN_AD). The SUSAN edge detector finds image features by using local information from a pseudo-global perspective. Thanks to the noise insensitivity and structure preservation properties of SUSAN, a better control can be provided to the subsequent diffusion process. To enhance the adaptability of the SUSAN_AD, the parameters of the SUSAN edge detector are calculated based on the statistics of a fully formed speckle (FFS) region. Different FFS estimation schemes are proposed for envelope-detected speckle images and log-compressed ultrasonic images. Adaptive diffusion threshold estimation and automatic diffusion termination criterion are employed to enhance the robustness of the method. Both synthetic and real ultrasound images are used to evaluate the proposed method. The performance of the SUSAN_AD is compared with four other existing speckle reduction methods. It is shown that the proposed method is superior to other methods in both noise reduction and detail preservation. [Copyright &y& Elsevier]

Pursuing better imaging quality and miniaturizing imaging devices are two trends in the current development of ultrasound imaging. While the first one leads to more complex and expensive imaging equipment, poor image quality is a common problem of portable ultrasound imaging systems. In this paper, an image reconstruction method was proposed to break through the imaging quality limitation of portable devices by introducing generative adversarial network (GAN) model into the field of ultrasound image reconstruction. We combined two GAN generator models, the encoder-decoder model and the U-Net model to build a sparse skip connection U-Net (SSC U-Net) to tackle this problem. To produce more realistic output, stabilize the training procedure, and improve spatial resolution in the reconstructed ultrasound images, a new loss function which combines adversarial loss, L1 loss, and differential loss was proposed. Three datasets including 50 pairs of simulation, 40 pairs of phantom, and 72 pairs of in vivo images were used to evaluate the reconstruction performance. Experimental results show that our SSC U-Net is able to reconstruct ultrasound images with improved quality. Compared with U-Net, our SSC U-Net is able to preserve more details in the reconstructed images and improve full width at half maximum (FWHM) of point targets by 3.23%. [ABSTRACT FROM AUTHOR]

Background: Improving imaging quality is a fundamental problem in ultrasound contrast agent imaging (UCAI) research. Plane wave imaging (PWI) has been deemed as a potential method for UCAI due to its' high frame rate and low mechanical index. High frame rate can improve the temporal resolution of UCAI. Meanwhile, low mechanical index is essential to UCAI since microbubbles can be easily broken under high mechanical index conditions. However, the clinical practice of ultrasound contrast agent plane wave imaging (UCPWI) is still limited by poor imaging quality for lack of transmit focus. The purpose of this study was to propose and validate a new post-processing method that combined with deep learning to improve the imaging quality of UCPWI. The proposed method consists of three stages: (1) first, a deep learning approach based on U-net was trained to differentiate the microbubble and tissue radio frequency (RF) signals; (2) then, to eliminate the remaining tissue RF signals, the bubble approximated wavelet transform (BAWT) combined with maximum eigenvalue threshold was employed. BAWT can enhance the UCA area brightness, and eigenvalue threshold can be set to eliminate the interference areas due to the large difference of maximum eigenvalue between UCA and tissue areas; (3) finally, the accurate microbubble imaging were obtained through eigenspace-based minimum variance (ESBMV).Results: The proposed method was validated by both phantom and in vivo rabbit experiment results. Compared with UCPWI based on delay and sum (DAS), the imaging contrast-to-tissue ratio (CTR) and contrast-to-noise ratio (CNR) was improved by 21.3 dB and 10.4 dB in the phantom experiment, and the corresponding improvements were 22.3 dB and 42.8 dB in the rabbit experiment.Conclusions: Our method illustrates superior imaging performance and high reproducibility, and thus is promising in improving the contrast image quality and the clinical value of UCPWI. [ABSTRACT FROM AUTHOR]

Background: Short-lag spatial coherence (SLSC) imaging, a newly proposed ultrasound imaging scheme, can offer a higher lesion detectability than conventional B-mode imaging. It requires a high focusing quality which can be satisfied by the synthetic aperture imaging mode. However, traditional nonadaptive synthesis for the SLSC still offers an unsatisfactory resolution. The spatial coherence estimation on the receive aperture cannot fully utilize the coherence information in two-dimensional (2D) echo data.Methods: To overcome these drawbacks, an improved SLSC scheme with adaptive synthesis on dual apertures is proposed in this paper. The minimum variance (MV) beamformer is applied in synthesizing both the receiving and transmitting apertures, while the SLSC function is estimated on both apertures as well. In this way, the resolution is enhanced by the MV implementation, while the coherence in dual apertures is fully utilized.Results: Simulations, phantom experiments, and in vivo studies are conducted to evaluate the performance of the proposed method. Results demonstrate that the proposed method achieves the best performance in terms of the contrast ratio (CR), contrast-to-noise ratio (CNR), and the speckle signal-to-noise ratio (SNR). Specifically, compared with the delay-and-sum (DAS) method, the proposed method achieves 42.5% higher CR, 412.7% higher CNR, and 402.9% higher speckle SNR in simulations. The resolution is also better than the DAS and conventional SLSC beamformers.Conclusions: The proposed method is a promising technique for improving the SLSC imaging quality and can provide better visualization for medical diagnosis. [ABSTRACT FROM AUTHOR]

Plane wave compounding (PWC) is an effective modality for ultrafast ultrasound imaging. It can provide higher resolution and better noise reduction than plane wave imaging (PWI). In this paper, a novel beamformer integrating the two-dimensional (2-D) minimum variance (MV) with the generalized coherence factor (GCF) is proposed to maintain the high resolution and contrast along with a high frame rate for PWC. To specify, MV beamforming is adopted in both the transmitting aperture and the receiving one. The subarray technique is therefore upgraded into the sub-matrix division. Then, the output of each submatrix is used to adaptively compute the GCF using a 2-D fast Fourier transform (FFT). After the 2-D MV beamforming and the 2-D GCF weighting, the final output can be obtained. Results of simulations, phantom experiments, and in vivo studies confirm the advantages of the proposed method. Compared with the delay-and-sum (DAS) beamformer, the full width at half maximum (FWHM) is 90% smaller and the contrast ratio (CR) improvement is 154% in simulations. The over-suppression of desired signals, which is a typical drawback of the coherence factor (CF), can be effectively avoided. The robustness against sound velocity errors is also enhanced. [ABSTRACT FROM AUTHOR]

Early screening and frequent monitoring effectively decrease the risk of severe scoliosis, but radiation exposure is a consequence of traditional radiograph examinations. Additionally, traditional X-ray images on the coronal or sagittal plane have difficulty providing three-dimensional (3-D) information on spinal deformities. The Scolioscan system provides an innovative 3-D spine imaging approach via ultrasonic scanning, and its feasibility has been demonstrated in numerous studies. In this paper, to further examine the potential of spinal ultrasonic data for describing 3-D spinal deformities, we propose a novel deep-learning tracker named Si-MSPDNet for extracting widely employed landmarks (spinous process (SP)) in ultrasonic images of spines and establish a 3-D spinal profile to measure 3-D spinal deformities. Si-MSPDNet has a Siamese architecture. First, we employ two efficient two-stage encoders to extract features from the uncropped ultrasonic image and the patch centered on the SP cut from the image. Then, a fusion block is designed to strengthen the communication between encoded features and further refine them from channel and spatial perspectives. The SP is a very small target in ultrasonic images, so its representation is weak in the highest-level feature maps. To overcome this, we ignore the highest-level feature maps and introduce parallel partial decoders to localize the SP. The correlation evaluation in the traditional Siamese network is also expanded to multiple scales to enhance cooperation. Furthermore, we propose a binary guided mask based on vertebral anatomical prior knowledge, which can further improve the performance of our tracker by highlighting the potential region with SP. The binary-guided mask is also utilized for fully automatic initialization in tracking. We collected spinal ultrasonic data and corresponding radiographs on the coronal and sagittal planes from 150 patients to evaluate the tracking precision of Si-MSPDNet and the performance of the generated 3-D spinal profile. Experimental results revealed that our tracker achieved a tracking success rate of 100% and a mean IoU of 0.882, outperforming some commonly used tracking and real-time detection models. Furthermore, a high correlation existed on both the coronal and sagittal planes between our projected spinal curve and that extracted from the spinal annotation in X-ray images. The correlation between the tracking results of the SP and their ground truths on other projected planes was also satisfactory. More importantly, the difference in mean curvatures was slight on all projected planes between tracking results and ground truths. Thus, this study effectively demonstrates the promising potential of our 3-D spinal profile extraction method for the 3-D measurement of spinal deformities using 3-D ultrasound data. • A novel tracker is proposed to real-time extracting spinous processes in 3D ultrasonic images. • Vertebral anatomical prior and spinal continuity are introduced into our tracker. • Experimental results indicate that our tracker can effectively describe 3-D spinal deformities. [ABSTRACT FROM AUTHOR]

This paper introduces a new beamformer, which combines the eigenspace based minimum variance (ESBMV) beamformer with a subarray coherence based postfilter (SCBP), for improving the quality of ultrasound plane-wave imaging. The ESBMV beamformer has been validated in improving the imaging contrast, but the difficulty in dividing the signal subspace limits the usage of it in the low signal-to-noise ratio (SNR) scenarios. Coherence factor (CF) based methods could optimize the output of a distortionless beamformer to reduce sidelobes, but the influence by the subarray decorrelation technique on the postfilter design has not attracted enough concern before. Accordingly, an ESBMV-SCBP beamformer was proposed in this paper, which used the coherence of the subarray signal to compute an SCBP to optimize the ESBMV results. Simulated and experimental data were used to evaluate the performance of the proposed method. The results showed that the ESBMV-SCBP method achieved an improved imaging quality compared with the ESBMV beamformer. In the simulation study, the contrast ratio (CR) for an anechoic cyst was improved by 9.88 dB and the contrast-to-noise ratio (CNR) was improved by 0.97 over the ESBMV. In the experimental study, the CR improvements for two anechoic cysts were 7.32 dB and 9.45 dB, while the CNRs were improved by 1.27 and 0.66, respectively. The ESBMV-SCBP also showed advantages over the ESBMV-Wiener beamformer in preserving a less grainy speckle, which is closer to that of distortionless beamformers and benefits the imaging contrast. With a relatively small extra computational load, the proposed method has potential to enhance the quality of the ultrasound plane-wave imaging. [ABSTRACT FROM AUTHOR]

Ultrasonography is one of the main imaging methods for monitoring and diagnosing atherosclerosis due to its non-invasiveness and low-cost. Automatic differentiation of carotid plaque fibrous cap integrity by using multi-modal ultrasound videos has significant diagnostic and prognostic value for cardiovascular and cerebrovascular disease patients. However, the task faces several challenges, including high variation in plaque location and shape, the absence of analysis mechanism focusing on fibrous cap, the lack of effective mechanism to capture the relevance among multi-modal data for feature fusion and selection, etc. To overcome these challenges, we propose a new target boundary and perfusion feature guided video analysis network (BP-Net) based on conventional B-mode ultrasound and contrast-enhanced ultrasound videos for assessing the integrity of fibrous cap. Based on our previously proposed plaque auto-tracking network, in our BP-Net, we further introduce the plaque edge attention module and reverse mechanism to focus the dual video analysis on the fiber cap of plaques. Moreover, to fully explore the rich information on the fibrous cap and inside/outside of the plaque, we propose a feature fusion module for B-mode and contrast video to filter out the most valuable features for fibrous cap integrity assessment. Finally, multi-head convolution attention is proposed and embedded into transformer-based network, which captures semantic features and global context information to obtain accurate evaluation of fibrous caps integrity. The experimental results demonstrate that the proposed method has high accuracy and generalizability with an accuracy of 92.35% and an AUC of 0.935, which outperforms than the state-of-the-art deep learning based methods. A series of comprehensive ablation studies suggest the effectiveness of each proposed component and show great potential in clinical application. [Display omitted] • The first boundary and perfusion feature guided dual-modality ultrasound video analysis network for fibrous cap integrity assessment. • A plaque edge attention module is proposed to focus the dual video analysis on the fibrous cap of plaques. • The proposed multi-modal fusion block can explore the inside/outside of the plaque and rich inter/intra modal interactions. • The multi-head convolution attention can utilize the robustness of CNN and sophisticated global modeling of Transformer. [ABSTRACT FROM AUTHOR]

A radiomics approach to sonoelastography, called "sonoelastomics," is proposed for classification of benign and malignant breast tumors. From sonoelastograms of breast tumors, a high-throughput 364-dimensional feature set was calculated consisting of shape features, intensity statistics, gray-level co-occurrence matrix texture features and contourlet texture features, which quantified the shape, hardness and hardness heterogeneity of a tumor. The high-throughput features were then selected for feature reduction using hierarchical clustering and three-feature selection metrics. For a data set containing 42 malignant and 75 benign tumors from 117 patients, seven selected sonoelastomic features achieved an area under the receiver operating characteristic curve of 0.917, an accuracy of 88.0%, a sensitivity of 85.7% and a specificity of 89.3% in a validation set via the leave-one-out cross-validation, revealing superiority over the principal component analysis, deep polynomial networks and manually selected features. The sonoelastomic features are valuable in breast tumor differentiation. [ABSTRACT FROM AUTHOR]

• The first automatic tracking and segmentation network for ultrasound video of multiple carotid plaques, and the effectiveness is confirmed by comprehensive experiments. • A new multi-object detector dual attention U-Net is proposed to segment carotid plaques and blood vessels simultaneously. • The newly proposed single-object tracker (MSTUnet) can utilize the previous tracking results efficiently and achieve stable tracking via a ranking channel attention module (RCAM), which is presented to select valuable information from previous tracking results. • The proposed method can detect target automatically and adjust the number of targets without manual initialization. Carotid plaque tracking and segmentation in ultrasound videos is the premise for subsequent plaque property evaluation and treatment plan development. However, the task is quite challenging, as it needs to address the problems of poor image quality, plaque shape variations among frames, the existence of multiple plaques, etc. To overcome these challenges, we propose a new automatic multi-plaque tracking and segmentation (AMPTS) framework. AMPTS consists of three modules. The first module is a multi-object detector, in which a Dual Attention U-Net is proposed to detect multiple plaques and vessels simultaneously. The second module is a set of single-object trackers that can utilize the previous tracking results efficiently and achieve stable tracking of the current target by using channel attention and a ranking strategy. To make the first module and the second module work together, a parallel tracking module based on a simplified 'tracking-by-detection' mechanism is proposed to solve the challenge of tracking object variation. Extensive experiments are conducted to compare the proposed method with several state-of-the-art deep learning based methods. The experimental results demonstrate that the proposed method has high accuracy and generalizability with a Dice similarity coefficient of 0.83 which is 0.16, 0.06 and 0.27 greater than MAST (Lai et al., 2020), Track R-CNN (Voigtlaender et al., 2019) and VSD (Yang et al., 2019) respectively and has made significant improvements on seven other indicators. In the additional Testing set 2, our method achieved a Dice similarity coefficient of 0.80, an accuracy of 0.79, a precision of 0.91, a Recall 0.70, a F1 score of 0.79, an AP@0.5 of 0.92, an AP@0.7 of 0.74, and an expected average overlap of 0.79. Numerous ablation studies suggest the effectiveness of each proposed component and the great potential for multiple carotid plaques tracking and segmentation in clinical practice. [Display omitted] [ABSTRACT FROM AUTHOR]