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The present study was showed excellent healing of grape seed extract of eye corneal ulcer of pigeons compare with control and gentamicin groups. Grape seed extract which composite many biochemical components have bioactive to recover and heal ulceration of the cornea. Cornea is a connective tissue to have collagen and fibers and the defect of cornea, therefore, the recovery is slow. The grape seed extract group showed good healing of corneal ulcer that evident the extract has good bioactive component assist in healing compare two groups. Histopathological images reveal to excellent healing. In conclusion the grape seed extract is an excellent agent to treat eye, corneal ulcer in pigeons and other animals. [ABSTRACT FROM AUTHOR]