1. Relationship between drinking patterns and the risk of type 2 diabetes: the Kansai Healthcare Study.
- Author
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Kyoko Kogawa Sato, Hayashi, Tomoshige, Harita, Nobuko, Koh, Hideo, Maeda, Isseki, Endo, Ginji, Nakamura, Yoshiko, Kambe, Hiroshi, and Kiyotaki, Chiharu
- Subjects
BLOOD sugar analysis ,TYPE 2 diabetes diagnosis ,TYPE 2 diabetes risk factors ,COMPARATIVE studies ,CONFIDENCE intervals ,ALCOHOL drinking ,LONGITUDINAL method ,QUESTIONNAIRES ,RESEARCH funding ,STATISTICAL hypothesis testing ,BODY mass index ,PROPORTIONAL hazards models ,DATA analysis software - Abstract
Background Moderate alcohol consumption is associated with a decreased risk of type 2 diabetes. However, the relationship between drinking patterns, such as the weekly frequency of alcohol consumption and the quantity per drinking day, and the incidence of type 2 diabetes has not been sufficiently addressed. Methods Study participants included 10 631 Japanese men aged 40e55 years without type 2 diabetes at entry. Type 2 diabetes was diagnosed if a fasting plasma glucose level was $7.0 mmol/l or if participants were taking diabetes medications. Data on alcohol consumption were obtained from questionnaires. Results During the 37 172 person-years of follow-up, we confirmed 878 cases of type 2 diabetes. Frequent alcohol consumption was associated with a low risk of type 2 diabetes. Compared to non-drinkers, the multiple-adjusted HR for those who drank 4e7 days weekly was 0.76 (95% CI, 0.63 to 0.92). To assess the association between drinking pattern and type 2 diabetes, we examined the joint association of the weekly frequency and the quantity per drinking day with type 2 diabetes. Men who consumed 0.1e2.0 or 2.1e4.0 US standard drinks per drinking day on 4e7 days weekly had a lower risk of type 2 diabetes (HR 0.74, 95% CI 0.58 to 0.95; HR 0.74, 95% CI 0.60 to 0.91, respectively) compared to non-drinkers. Conclusions More frequent alcohol consumption lowered the risk of type 2 diabetes. Light to moderate alcohol consumption per drinking day on 4e7 days weekly lowered the risk of type 2 diabetes compared to non-drinkers. [ABSTRACT FROM AUTHOR]
- Published
- 2012
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