Search

This article discusses how to diagnose and manage patients with ketosis prone type 2 diabetes [ABSTRACT FROM AUTHOR]

Aims: To establish the knowledge of women with pre-gestational diabetes about of the risks of diabetes in pregnancy, and investigate their pregnancy plans, contraceptive choices, and preparedness for pregnancy.Methods: Women of reproductive age attending diabetes clinics across a single busy metropolitan NHS Trust were invited to fill in a questionnaire about pregnancy and contraception. The electronic health records of those women were also reviewed.Results: Ninety-six women completed the questionnaire. The majority of respondents (94%) had Type 1 Diabetes. Only 3% of women met the criteria of 'prepared for pregnancy'. Low efficacy contraception was used by 32% of women. Most women were only aware of a few risks to the mother and fetus in pregnancy, though the majority of women were aware of the importance of good glycaemic control before pregnancy. Previous pregnancies, or attendance at pre-conception counselling, did not improve participant knowledge.Conclusions: Many women with diabetes of reproductive age are poorly prepared for pregnancy, but many are also using less effective contraceptive methods. These areas should be addressed if the poor pregnancy outcome in women with diabetes are to be improved, possibly through the development of an evidenced-based structured education course to target pre-conception and contraception. [ABSTRACT FROM AUTHOR]

What's new?: Chronic sleep disturbance is common for people with Type 1 diabetes.Fear of nocturnal hypoglycaemia is causing frequent nocturnal blood glucose testing causing impaired sleep.New strategies for the prevention of nocturnal hypoglycaemia need to be devised and tested.The consequences of chronic sleep disturbance for people living with diabetes and their families needs to be appreciated by their clinical advisors. [ABSTRACT FROM AUTHOR]

An introduction to articles published within the issue is presented, including one which reviews evidence on the association of glucose variability with the development of complications in type 1 diabetes, another which reviews the impact of insulin analogue development and whether clinical outcomes have improved with newer insulins, and another which examines whether lifestyle changes are adjuncts or alternatives to diabetes medications.

The article discusses the study on the role of carbohydrates, fats and proteins in managing type 2 diabetes. The study reportedly involved a narrative review of three databases using a structured search strategy. The results revealed that there is no optimal ratio of macronutrients to improve glycaemic control or reduce the risk of heart disease.

The article discusses a study focusing on the access to and reimbursement for continuous glucose monitoring systems (CGM) for Type 1 diabetes patients in England. Topics discussed include the clinical guidelines published by the National Institute for Health and Care Excellence (NICE) in 2015; the Clinical Commissioning Groups (CCGs) in England, which provide funding for real-time CGM; and the discrepancies in policy regarding cost-effective use of routinely commissioned CGM.

The article discusses a study conducted for assessing the use of continuous subcutaneous insulin infusion (CSII) also known as insulin pump therapy for children with type 1 diabetes. Topics include using CSII for controlling glycaemic index, using insulin injection doses, and impact of CSII on the rates of hypoglycaemia.

Real‐time continuous glucose monitors using subcutaneous needle‐type sensors continue to develop. The limitations of currently available systems, however, include time lag behind changes in blood glucose, the invasive nature of such systems, and in some cases, their accuracy. Non‐invasive techniques have been developed, but, to date, no commercial device has been successful. A key research priority for people with Type 1 diabetes identified by the James Lind Alliance was to identify ways of monitoring blood glucose constantly and accurately using a discrete device, invasive or non‐invasive. Integration of such a sensor is important in the development of a closed‐loop system and the technology must be rapid, selective and acceptable for continuous use by individuals. The present review provides an update on existing continuous glucose‐sensing technologies, and an overview of emergent techniques, including their accuracy and limitations. What's new?: One of 10 key research priorities identified by the James Lind Alliance Type 1 diabetes Priority Setting Partnership was to investigate whether it is possible to monitor blood sugar levels constantly and accurately with a discrete device (non‐invasive or invasive).This paper provides an overview of the latest glucose‐sensing techniques, currently marketed products and their accuracy.To date, no device based on a non‐invasive technique has successfully reached the commercial market. We review the technological challenges faced, clinical impact and future directions in continuous glucose monitoring. [ABSTRACT FROM AUTHOR]

Abstract: Aim: Hypoglycaemia in Type 1 diabetes is associated with mortality and morbidity, especially where awareness of hypoglycaemia is impaired. Clinical pathways for access to continuous glucose monitoring (CGM) and flash glucose monitoring technologies are unclear. We assessed the impact of CGM and flash glucose monitoring in a high‐risk group of people with Type 1 diabetes. Methods: A randomized, non‐masked parallel group study was undertaken. Adults with Type 1 diabetes using a multiple‐dose insulin‐injection regimen with a Gold score of ≥ 4 or recent severe hypoglycaemia were recruited. Following 2 weeks of blinded CGM, they were randomly assigned to CGM (Dexcom G5) or flash glucose monitoring (Abbott Freestyle Libre) for 8 weeks. The primary outcome was the difference in time spent in hypoglycaemia (below 3.3 mmol/l) from baseline to endpoint with CGM versus flash glucose monitoring. Results: Some 40 participants were randomized to CGM (n = 20) or flash glucose monitoring (n = 20). The participants (24 men, 16 women) had a median (IQR) age of 49.6 (37.5–63.5) years, duration of diabetes of 30.0 (21.0–36.5) years and HbA1c of 56 (48–63) mmol/mol [7.3 (6.5–7.8)%]. The baseline median percentage time < 3.3 mmol/l was 4.5% in the CGM group and 6.7% in the flash glucose monitoring. At the end‐point the percentage time < 3.3 mmol/l was 2.4%, and 6.8% respectively (median between group difference −4.3%, P = 0.006). Time spent in hypoglycaemia at all thresholds, and hypoglycaemia fear, were different between groups, favouring CGM. Conclusion: CGM more effectively reduces time spent in hypoglycaemia in people with Type 1 diabetes and impaired awareness of hypoglycaemia compared with flash glucose monitoring. (Clinical Trial Registry No: NCT03028220) [ABSTRACT FROM AUTHOR]