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1. ARF--NRF2: A new checkpoint for oxidative stress responses?

Author

Chen, Delin, Tavana, Omid, and Gu, Wei

Subjects
*TRANSCRIPTION factors, *OXIDATIVE stress, *GENE expression, *TUMOR suppressor genes, *ANTIOXIDANTS
Abstract

NRF2 (nuclear factor erythroid 2-related factor 2) is a transcription factor which plays a major role in oxidative stress responses by regulating antioxidant gene expression. We have recently identified the ARF tumor suppressor as a key regulator of NRF2. ARF can significantly inhibit NRF2 transcriptional activities, and the ARF-NRF2 interaction may function as a novel checkpoint for oxidative stress responses. [ABSTRACT FROM AUTHOR]

Published
2018
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