1. The roles of KRAS in cancer metabolism, tumor microenvironment and clinical therapy.
- Author
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Ma Q, Zhang W, Wu K, and Shi L
- Subjects
- Humans, Animals, Molecular Targeted Therapy, Epigenesis, Genetic, Gene Expression Regulation, Neoplastic, Metabolic Networks and Pathways, Tumor Microenvironment, Neoplasms metabolism, Neoplasms genetics, Neoplasms pathology, Neoplasms therapy, Proto-Oncogene Proteins p21(ras) genetics, Proto-Oncogene Proteins p21(ras) metabolism, Mutation
- Abstract
KRAS is one of the most mutated genes, driving alternations in metabolic pathways that include enhanced nutrient uptaking, increased glycolysis, elevated glutaminolysis, and heightened synthesis of fatty acids and nucleotides. However, the beyond mechanisms of KRAS-modulated cancer metabolisms remain incompletely understood. In this review, we aim to summarize current knowledge on KRAS-related metabolic alterations in cancer cells and explore the prevalence and significance of KRAS mutation in shaping the tumor microenvironment and influencing epigenetic modification via various molecular activities. Given that cancer cells rely on these metabolic changes to sustain cell growth and survival, targeting these processes may represent a promising therapeutic strategy for KRAS-driven cancers., Competing Interests: Declarations. Ethics approval and consent to participate: Not applicable in this article. Competing interests: The authors declare no competing interests., (© 2025. The Author(s).)
- Published
- 2025
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