1. Cryptococcal Pleuritis Presenting with Lymphocyte-predominant and High Levels of Adenosine Deaminase in Pleural Effusions Coincident with Pulmonary Tuberculosis.
- Author
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Kushima Y, Takizawa H, Machida Y, Umetsu T, Ikeda N, Miyoshi M, Chibana K, Shimizu Y, Takemasa A, and Ishii Y
- Subjects
- Aged, 80 and over, Anti-Inflammatory Agents therapeutic use, Coinfection physiopathology, Cryptococcus neoformans isolation & purification, Humans, Lymphocytes chemistry, Male, Mycobacterium tuberculosis isolation & purification, Pleura microbiology, Pleura physiopathology, Pleural Effusion microbiology, Pleurisy microbiology, Treatment Outcome, Tuberculosis, Pleural drug therapy, Tuberculosis, Pleural microbiology, Tuberculosis, Pulmonary drug therapy, Tuberculosis, Pulmonary microbiology, Adenosine Deaminase analysis, Coinfection drug therapy, Coinfection microbiology, Cryptococcosis drug therapy, Prednisone therapeutic use, Tuberculosis, Pleural physiopathology, Tuberculosis, Pulmonary physiopathology
- Abstract
Co-infection with cryptococcus and tuberculosis has rarely been reported. We herein report a case of an 80-year-old man with cryptococcal pleuritis concurrent with pulmonary tuberculosis. He was admitted for progression of left pleural effusion and consolidation in the left upper lobe. Culture for Mycobacterium tuberculosis was positive in sputum, and analyses of pleural effusion revealed lymphocyte-predominant high levels of adenosine deaminase (ADA). Medical thoracoscopy revealed massive infiltration of Cryptococcus neoformans in pleura without granuloma. This is the first case report of cryptococcal pleuritis coincident with pulmonary tuberculosis. Cryptococcal pleuritis should be ruled out when the adenosine deaminase levels are elevated in pleural effusion.
- Published
- 2018
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