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1. Chicken ovalbumin upstream promoter-transcription factor (COUP-TF) modulates expression of the Purkinje cell protein-2 gene. A potential role for COUP-TF in repressing premature thyroid hormone action in the developing brain.

2. Beta receptor isoforms are not essential for thyroid hormone-dependent acceleration of PCP-2 and myelin basic protein gene expression in the developing brains of neonatal mice.

3. Purkinje cell protein-2 cis-elements mediate repression of T3-dependent transcriptional activation.

4. Transient stimulation of myelin basic protein gene expression in differentiating cultured oligodendrocytes: a model for 3,5,3'-triiodothyronine-induced brain development.

5. Quantitation of rat tissue thyroid hormone binding receptor isoforms by immunoprecipitation of nuclear triiodothyronine binding capacity.

6. Functional relationship of thyroid hormone-induced lipogenesis, lipolysis, and thermogenesis in the rat.

7. Binding of 3,5,3'-triiodothyronine (T3) and its analogs to the in vitro translational products of c-erbA protooncogenes: differences in the affinity of the alpha- and beta-forms for the acetic acid analog and failure of the human testis and kidney alpha-2 products to bind T3.

8. An analysis of the interrelationship of nuclear and plasma triiodothyronine in the sea lamprey, lake trout, and rat: evolutionary considerations.

11. Stimulation of hepatic mitochondrial alpha-glycerophosphate dehydrogenase and malic enzyme by L-triiodothyronine. Characteristics of the response with specific nuclear thyroid hormone binding sites fully saturated.

12. Stereospecific transport of triiodothyronine from plasma to cytosol and from cytosol to nucleus in rat liver, kidney, brain, and heart.

13. Thyroid hormone-, carbohydrate, and age-dependent regulation of a methylation site in the hepatic S14 gene.

14. Binding of selected iodothyronine analogues to receptor sites of isolated rat hepatic nuclei. High correlation between structural requirements for nuclear binding and biological activity.

15. Interaction of T3 and carbohydrate in the induction of lipogenic enzymes.

16. Triiodothyronine regulation of multiple rat hepatic genes: requirement for ongoing protein synthesis.

17. Alpha-amanitin administration results in a temporary inhibition of hepatic enzyme induction by triiodothyronine: further evidence favoring a long-lived mediator of thyroid hormone action.

18. Comparison of the metabolism and distribution of L-triiodothyronine and triiodothyroacetic acid in the rat: a possible explanation of differential hormonal potency.

19. Limitations in the conventional analysis of the interaction of triiodothyronine with solubilized nuclear receptor sites. Inapparent binding of triiodothyronine to nonspecific binding sites.

20. Opposing effects of glucagon and triiodothyronine on the hepatic levels of messenger ribonucleic acid S14 and the dependence of such effects on circadian factors.

21. Decreased serum triiodothyronine in starving rats is due primarily to diminished thyroidal secretion of thyroxine.

22. Relationship between the accumulation of pituitary growth hormone and nuclear occupancy by triiodothyronine in the rat.

23. Ontogenesis of 3,5,3'-triiodothyronine receptors in neonatal rat brain: dissociation between receptor concentration and stimulation of oxygen consumption by 3,5,3'-triiodothyronine.

24. Inhibition of malic enzyme induction by triiodothyronine in the diabetic rat: reversal by fructose feeding.

25. Interaction of thyroid hormones with target tissues: effects of hepatic mRNA population.

26. Tissue differences in the concentration of triiodothyronine nuclear binding sites in the rat: liver, kidney, pituitary, heart, brain, spleen, and testis.

27. Nuclear receptors and the initiation of thyroid hormone action.

28. Nuclear binding capacity appears to limit the hepatic response to L-triiodothyronine (T3).

29. Nonlinear (amplified) relationship between nuclear occupancy by triiodothyronine and the appearance rate of hepatic alpha-glycerophosphate dehydrogenase and malic enzyme in the rat.

33. Stereospecific transport of triiodothyronine to cytoplasm and nucleus in GH1 cells.

34. Paradoxical effects of cycloheximide on the ultra-rapid induction of two hepatic mRNA sequences by triiodothyronine (T3).

35. Thyroid hormones influence starvation-induced hepatic protein loss in the rat: possible role of thyroid hormones in the generation of labile protein.

36. Regulation of gene S-14 by triiodothyronine in liver.

37. Triiodothyronine rapidly reverses inhibition of S14 gene transcription by glucagon.

38. Determination of common parameters fo iodothyronine metabolism and distribution in man by noncompartmental analysis.

39. Time course of hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and messenger ribonucleic acid, biliary lipid secretion, and hepatic cholesterol content in methimazole-treated hypothyroid and hypophysectomized rats after triiodothyronine administration: possible linkage of cholesterol synthesis to biliary secretion.

40. Selective alterations in hepatic enzyme response after reduction of nuclear triiodothyronine receptor sites by partial hepatectomy and starvation.

41. Limited binding capacity sites for L-triiodothyronine in rat liver nuclei. Nuclear-cytoplasmic interrelation, binding constants, and cross-reactivity with L-thyroxine.

42. The regulation of lipogenesis by thyroid hormone and its contribution to thermogenesis.

43. Quantitation of rat liver messenger ribonucleic acid for malic enzyme during induction by thyroid hormone.

44. Nuclear receptors and thyroid hormone action: a progress report.

45. Glucose and triiodothyronine both induce malic enzyme in the rat hepatocyte culture: evidence that triiodothyronine multiplies a primary glucose-generated signal.

46. Transcellular and transnuclear transport of 3,5,3'-triiodothyronine in isolated hepatocytes.

48. Distribution and metabolism of L- and D-triiodothyronine (T3) in the rat: preferential accumulation of L-T3 by hepatic and cardiac nuclei as a probable explanation of the differential biological potency of T3 enantiomers.

50. Replacement dose, metabolism, and bioavailability of levothyroxine in the treatment of hypothyroidism. Role of triiodothyronine in pituitary feedback in humans.

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