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Your search keyword '"Alexander, Kevin M."' showing total 6 results
Start Over Author "Alexander, Kevin M." Topic transthyretin
6 results on '"Alexander, Kevin M."'

1. Proteotoxicity and Autophagy in Neurodegenerative and Cardiovascular Diseases

Author

Alexander, Kevin M., Morgado, Isabel, Liao, Ronglih, Dhalla, Naranjan S., Series Editor, Bolli, Roberto, Editorial Board Member, Goyal, Ramesh, Editorial Board Member, Kartha, Chandrasekharan, Editorial Board Member, Kirshenbaum, Lorrie, Editorial Board Member, Makino, Naoki, Editorial Board Member, Mehta, Jawahar L. L., Editorial Board Member, Ostadal, Bohuslav, Editorial Board Member, Pierce, Grant N., Editorial Board Member, Slezak, Jan, Editorial Board Member, Varro, Andras, Editorial Board Member, Werdan, Karl, Editorial Board Member, Weglicki, William B., Editorial Board Member, and Kirshenbaum, Lorrie A., editor

Published
2022
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6. Novel pharmacotherapies for cardiac amyloidosis.

Author

Alexander, Kevin M., Singh, Avinainder, and Falk, Rodney H.

Subjects
*CARDIAC amyloidosis, *DRUG therapy, *HEART failure, *PROTEIN folding, *DISEASE progression, *RANDOMIZED controlled trials, *THERAPEUTICS
Abstract

Amyloidosis refers to a range of protein misfolding disorders that can cause organ dysfunction through progressive fibril deposition. Cardiac involvement often leads to significant morbidity and mortality and increasingly has been recognized as an important cause of heart failure. The two main forms of cardiac amyloidosis, light chain (AL) and transthyretin (ATTR) amyloidosis, have distinct mechanisms of pathogenesis. Recent insights have led to the development of novel pharmacotherapies with the potential to significantly impact each disease. This review will summarize the preclinical and clinical data for these emerging treatments for AL and ATTR amyloidosis. [ABSTRACT FROM AUTHOR]

Published
2017
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