1. Extended spectrum β-lactamase-producing Enterobacteriaceae infection in heart and lung transplant recipients and in mechanical circulatory support recipients.
- Author
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Bui KT, Mehta S, Khuu TH, Ross D, Carlson M, Leibowitz MR, Schaenman JM, Saggar R, Lynch JP 3rd, Ardehali A, and Kubak BM
- Subjects
- Adult, Aged, Enterobacteriaceae Infections mortality, Escherichia coli Infections epidemiology, Escherichia coli Infections mortality, Female, Humans, Incidence, Klebsiella Infections epidemiology, Klebsiella Infections mortality, Male, Middle Aged, Retrospective Studies, Survival Rate, Time Factors, Enterobacteriaceae metabolism, Enterobacteriaceae Infections epidemiology, Heart Transplantation statistics & numerical data, Heart-Assist Devices statistics & numerical data, Lung Transplantation statistics & numerical data, Transplantation statistics & numerical data, beta-Lactamases metabolism
- Abstract
Background: Extended spectrum β-lactamase (ESBL)-producing gram-negative bacilli are increasingly reported in patients with a variety of risk factors including prior cephalosporin and antibiotic usage, prolonged hospitalizations, existence of comorbid conditions, and critical illness., Methods: Retrospective review of infections caused by ESBL-producing Enterobacteriaceae was performed in heart transplant (HTx), lung transplant (LTx), and mechanical circulatory support (MCS) device recipients at a large transplant center., Results: Among 1065 patients transplanted/implanted, the incidence of ESBL-related infections (bacteremia, urinary tract infections, pneumonia, central venous catheter-associated infection, and wound infections) in HTx, LTx, and MCS device recipients was reported at 2.2%, 5.5%, and 10.7%, respectively, caused by ESBL-producing Klebsiella pneumoniae, Escherichia coli, Klebsiella oxytoca, and Citrobacter freundii., Conclusions: Early detection and adequate duration of therapy for ESBL-producing Enterobacteriaceae in solid organ transplants and MCS device recipients are essential in successful patient outcomes including prevention of recurrent infection.
- Published
- 2014
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