1. Signalling pathways and transcriptional regulators orchestrating liver development and cancer.
- Author
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Campbell SA, Stephan TL, Lotto J, Cullum R, Drissler S, and Hoodless PA
- Subjects
- Cell Differentiation, Epithelial Cells cytology, Epithelial Cells metabolism, Hepatocytes cytology, Hepatocytes metabolism, Humans, Liver cytology, Liver metabolism, Liver Neoplasms metabolism, Liver Regeneration, Tissue Engineering, Liver growth & development, Liver Neoplasms pathology, Signal Transduction physiology, Transcription Factors metabolism
- Abstract
Liver development is controlled by key signals and transcription factors that drive cell proliferation, migration, differentiation and functional maturation. In the adult liver, cell maturity can be perturbed by genetic and environmental factors that disrupt hepatic identity and function. Developmental signals and fetal genetic programmes are often dysregulated or reactivated, leading to dedifferentiation and disease. Here, we highlight signalling pathways and transcriptional regulators that drive liver cell development and primary liver cancers. We also discuss emerging models derived from pluripotent stem cells, 3D organoids and bioengineering for improved studies of signalling pathways in liver cancer and regenerative medicine., Competing Interests: Competing interests The authors declare no competing or financial interests., (© 2021. Published by The Company of Biologists Ltd.)
- Published
- 2021
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