Search

Your search keyword '"Chen, Kunhao"' showing total 2 results
Start Over Author "Chen, Kunhao" Topic tranexamic acid
2 results on '"Chen, Kunhao"'

1. The Efficacy and Safety of Prophylactic Intravenous Tranexamic Acid on Perioperative Blood Loss in Patients Treated with Posterior Lumbar Interbody Fusion.

Author

Sun H, Deng L, Deng J, Wang J, Zhang H, Chen K, Li H, Ning X, and Yang H

Subjects
Antifibrinolytic Agents adverse effects, Blood Loss, Surgical statistics & numerical data, Blood Transfusion, Autologous, Body Mass Index, Bone Transplantation methods, Case-Control Studies, Drainage statistics & numerical data, Female, Hospitalization statistics & numerical data, Humans, Infusions, Intravenous, Intervertebral Disc Displacement surgery, Male, Middle Aged, Postoperative Complications etiology, Retrospective Studies, Spinal Fusion adverse effects, Spinal Stenosis surgery, Spondylolisthesis surgery, Tranexamic Acid adverse effects, Treatment Outcome, Antifibrinolytic Agents administration & dosage, Blood Loss, Surgical prevention & control, Lumbar Vertebrae surgery, Spinal Fusion methods, Tranexamic Acid administration & dosage
Abstract

Objective: To investigate the efficacy and safety of a prophylactic intravenous administration of tranexamic acid (TXA) 30 minutes before skin incision on perioperative blood loss in patients treated with posterior lumbar interbody fusion (PLIF)., Methods: A total of 63 patients who underwent PLIF were recruited and divided into a TXA group (n = 26) and a control group (n = 37). Intraoperative blood loss, postoperative blood loss, duration of tube drainage, hospitalization time, blood transfusion rate, and incidence of complications were compared between the 2 groups., Results: There were no significant differences in the demographic characteristics and laboratory results between the 2 groups. The intraoperative blood loss, 24-hour postoperative drainage volume, 24-hour postoperative hidden blood loss, perioperative overt blood loss, hospitalization time, and postoperative duration of tube drainage were significantly reduced in the TXA group compared with the control group. In addition, the perioperative blood transfusion rate was lower in the TXA group (7.7%) than in the control group (16.22%), but the difference was not statistically significant. During a 3-month follow-up period, no pulmonary embolism, liver failure, or renal dysfunction was observed in the 2 groups. Likewise, the incidence of deep venous thrombosis was not found in the TXA group compared with 1 case in the control group, hence the difference was not statistically significant., Conclusions: A prophylactic intravenous administration of TXA 30 minutes before skin incision effectively reduces the perioperative blood loss, duration of tube drainage, and hospitalization time, and it does not increase the risk of complications. However, TXA may not be able to decrease the rate of blood transfusion., (Copyright © 2019 Elsevier Inc. All rights reserved.)

Published
2019
Full Text
View/download PDF

2. The Efficacy and Safety of Prophylactic Intravenous Tranexamic Acid on Perioperative Blood Loss in Patients Treated with Posterior Lumbar Interbody Fusion

Author

Chen Kunhao, Jin Deng, Hao Zhang, Hong Sun, Luoyi Deng, Xu Ning, Jian Wang, Hua Yang, and Hongfei Li

Subjects
Male, Blood transfusion, medicine.medical_treatment, Blood Loss, Surgical, Body Mass Index, Blood Transfusion, Autologous, 03 medical and health sciences, Postoperative Complications, Spinal Stenosis, 0302 clinical medicine, medicine, Humans, In patient, Infusions, Intravenous, Retrospective Studies, Bone Transplantation, Lumbar Vertebrae, business.industry, Incidence (epidemiology), Perioperative, Middle Aged, medicine.disease, Antifibrinolytic Agents, Pulmonary embolism, Perioperative blood loss, Hospitalization, Venous thrombosis, Spinal Fusion, Treatment Outcome, Tranexamic Acid, Case-Control Studies, 030220 oncology & carcinogenesis, Anesthesia, Drainage, Female, Surgery, Neurology (clinical), Spondylolisthesis, business, Intervertebral Disc Displacement, 030217 neurology & neurosurgery, Tranexamic acid, medicine.drug
Abstract

Objective To investigate the efficacy and safety of a prophylactic intravenous administration of tranexamic acid (TXA) 30 minutes before skin incision on perioperative blood loss in patients treated with posterior lumbar interbody fusion (PLIF). Methods A total of 63 patients who underwent PLIF were recruited and divided into a TXA group (n = 26) and a control group (n = 37). Intraoperative blood loss, postoperative blood loss, duration of tube drainage, hospitalization time, blood transfusion rate, and incidence of complications were compared between the 2 groups. Results There were no significant differences in the demographic characteristics and laboratory results between the 2 groups. The intraoperative blood loss, 24-hour postoperative drainage volume, 24-hour postoperative hidden blood loss, perioperative overt blood loss, hospitalization time, and postoperative duration of tube drainage were significantly reduced in the TXA group compared with the control group. In addition, the perioperative blood transfusion rate was lower in the TXA group (7.7%) than in the control group (16.22%), but the difference was not statistically significant. During a 3-month follow-up period, no pulmonary embolism, liver failure, or renal dysfunction was observed in the 2 groups. Likewise, the incidence of deep venous thrombosis was not found in the TXA group compared with 1 case in the control group, hence the difference was not statistically significant. Conclusions A prophylactic intravenous administration of TXA 30 minutes before skin incision effectively reduces the perioperative blood loss, duration of tube drainage, and hospitalization time, and it does not increase the risk of complications. However, TXA may not be able to decrease the rate of blood transfusion.

Published
2019

Catalog

Books, media, physical & digital resources
See catalog results