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8 results on '"Heydemann, Peter"'

1. Point-of-care testing for Toxoplasma gondii IgG/IgM using Toxoplasma ICT IgG-IgM test with sera from the United States and implications for developing countries.

Author

Begeman IJ, Lykins J, Zhou Y, Lai BS, Levigne P, El Bissati K, Boyer K, Withers S, Clouser F, Noble AG, Rabiah P, Swisher CN, Heydemann PT, Contopoulos-Ioannidis DG, Montoya JG, Maldonado Y, Ramirez R, Press C, Stillwaggon E, Peyron F, and McLeod R

Subjects
Costs and Cost Analysis, Developing Countries, Diagnostic Tests, Routine economics, Diagnostic Tests, Routine methods, Humans, Immunoassay economics, Sensitivity and Specificity, United States, Antibodies, Protozoan blood, Immunoassay methods, Immunoglobulin G blood, Immunoglobulin M blood, Point-of-Care Testing economics, Toxoplasma immunology, Toxoplasmosis diagnosis
Abstract

Background: Congenital toxoplasmosis is a serious but preventable and treatable disease. Gestational screening facilitates early detection and treatment of primary acquisition. Thus, fetal infection can be promptly diagnosed and treated and outcomes can be improved., Methods: We tested 180 sera with the Toxoplasma ICT IgG-IgM point-of-care (POC) test. Sera were from 116 chronically infected persons (48 serotype II; 14 serotype I-III; 25 serotype I-IIIa; 28 serotype Atypical, haplogroup 12; 1 not typed). These represent strains of parasites infecting mothers of congenitally infected children in the U.S. 51 seronegative samples and 13 samples from recently infected persons known to be IgG/IgM positive within the prior 2.7 months also were tested. Interpretation was confirmed by two blinded observers. A comparison of costs for POC vs. commercial laboratory testing methods was performed., Results: We found that this new Toxoplasma ICT IgG-IgM POC test was highly sensitive (100%) and specific (100%) for distinguishing IgG/IgM-positive from negative sera. Use of such reliable POC tests can be cost-saving and benefit patients., Conclusions: Our work demonstrates that the Toxoplasma ICT IgG-IgM test can function reliably as a point-of-care test to diagnose Toxoplasma gondii infection in the U.S. This provides an opportunity to improve maternal-fetal care by using approaches, diagnostic tools, and medicines already available. This infection has serious, lifelong consequences for infected persons and their families. From the present study, it appears a simple, low-cost POC test is now available to help prevent morbidity/disability, decrease cost, and make gestational screening feasible. It also offers new options for improved prenatal care in low- and middle-income countries.

Published
2017
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2. Clustering of Toxoplasma gondii Infections Within Families of Congenitally Infected Infants.

Author

Contopoulos-Ioannidis D, Wheeler KM, Ramirez R, Press C, Mui E, Zhou Y, Van Tubbergen C, Prasad S, Maldonado Y, Withers S, Boyer KM, Noble AG, Rabiah P, Swisher CN, Heydemann P, Wroblewski K, Karrison T, Grigg ME, Montoya JG, and McLeod R

Subjects
Adolescent, Agglutination Tests, Antibodies, Protozoan blood, Chicago epidemiology, Child, Child, Preschool, Cohort Studies, Enzyme-Linked Immunosorbent Assay, Female, Humans, Immunoglobulin G blood, Immunoglobulin M blood, Incidence, Infant, Infant, Newborn, Male, Pregnancy, Prevalence, Cluster Analysis, Family Health, Fathers, Toxoplasmosis epidemiology
Abstract

Background: Family clusters and epidemics of toxoplasmosis in North, Central, and South America led us to determine whether fathers of congenitally infected infants in the National Collaborative Chicago-Based Congenital Toxoplasmosis Study (NCCCTS) have a high incidence of Toxoplasma gondii infection., Methods: We analyzed serum samples collected from NCCCTS families between 1981 and 2013. Paternal serum samples were tested for T. gondii antibodies with immunoglobulin (Ig) G dye test and IgM enzyme-linked immunosorbent assay. Additional testing of paternal serum samples was performed with differential-agglutination and IgG avidity tests when T. gondii IgG and IgM results were positive and serum samples were collected by the 1-year visit of the congenitally infected child. Prevalence of paternal seropositivity and incidence of recent infection were calculated. We analyzed whether certain demographics, maternal parasite serotype, risk factors, or maternal/infant clinical manifestations were associated with paternal T. gondii infection status., Results: Serologic testing revealed a high prevalence (29 of 81; 36%) of T. gondii infection in fathers, relative to the average seropositivity rate of 9.8% for boys and men aged 12-49 years in the United States between 1994 and 2004 (P < .001). Moreover, there was a higher-than-expected incidence of recent infections among fathers with serum samples collected by the 1-year visit of their child (6 of 45; 13%; P < .001). No demographic patterns or clinical manifestations in mothers or infants were associated with paternal infections, except for sandbox exposure., Conclusions: The high prevalence of chronic and incidence of recent T. gondii infections in fathers of congenitally infected children indicates that T. gondii infections cluster within families in North America. When a recently infected person is identified, family clustering and community risk factors should be investigated for appropriate clinical management., (© The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.)

Published
2015
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3. Building Programs to Eradicate Toxoplasmosis Part I: Introduction and Overview

Author

Felín, Mariangela Soberón, Wang, Kanix, Moreira, Aliya, Grose, Andrew, Leahy, Karen, Zhou, Ying, Clouser, Fatima Alibana, Siddiqui, Maryam, Leong, Nicole, Goodall, Perpetua, Michalowski, Morgan, Ismail, Mahmoud, Christmas, Monica, Schrantz, Stephen, Caballero, Zuleima, Norero, Ximena, Estripeaut, Dora, Ellis, David, Raggi, Catalina, Castro, Catherine, Moossazadeh, Davina, Ramirez, Margarita, Pandey, Abhinav, Ashi, Kevin, Dovgin, Samantha, Dixon, Ashtyn, Li, Xuan, Begeman, Ian, Heichman, Sharon, Lykins, Joseph, Villalobos-Cerrud, Delba, Fabrega, Lorena, Montalvo, José Luis Sanchez, Mendivil, Connie, Quijada, Mario R., Fernández-Pirla, Silvia, de La Guardia, Valli, Wong, Digna, de Guevara, Mayrene Ladrón, Flores, Carlos, Borace, Jovanna, García, Anabel, Caballero, Natividad, Rengifo-Herrera, Claudia, de Saez, Maria Theresa Moreno, Politis, Michael, Wroblewski, Kristen, Karrison, Theodore, Ross, Stephanie, Dogra, Mimansa, Dhamsania, Vishan, Graves, Nicholas, Kirchberg, Marci, Mathur, Kopal, Aue, Ashley, Restrepo, Carlos M., Llanes, Alejandro, Guzman, German, Rebellon, Arturo, Boyer, Kenneth, Heydemann, Peter, Noble, A. Gwendolyn, Swisher, Charles, Rabiah, Peter, Withers, Shawn, Hull, Teri, Su, Chunlei, Blair, Michael, Latkany, Paul, Mui, Ernest, Vasconcelos-Santos, Daniel Vitor, Villareal, Alcibiades, Perez, Ambar, Galvis, Carlos Andrés Naranjo, Montes, Mónica Vargas, Perez, Nestor Ivan Cardona, Ramirez, Morgan, Chittenden, Cy, Wang, Edward, Garcia-López, Laura Lorena, Muñoz-Ortiz, Juliana, Rivera-Valdivia, Nicolás, Bohorquez-Granados, María Cristina, de-la-Torre, Gabriela Castaño, Padrieu, Guillermo, Hernandez, Juan David Valencia, Celis-Giraldo, Daniel, Dávila, Juan Alejandro Acosta, Torres, Elizabeth, Oquendo, Manuela Mejia, Arteaga-Rivera, José Y., Nicolae, Dan L., Rzhetsky, Andrey, Roizen, Nancy, Stillwaggon, Eileen, Sawers, Larry, Peyron, Francois, Wallon, Martine, Chapey, Emanuelle, Levigne, Pauline, Charter, Carmen, De Frias, Migdalia, Montoya, Jose, Press, Cindy, Ramirez, Raymund, Contopoulos-Ioannidis, Despina, Maldonado, Yvonne, Liesenfeld, Oliver, Gomez, Carlos, Wheeler, Kelsey, Holfels, Ellen, Frim, David, McLone, David, Penn, Richard, Cohen, William, Zehar, Samantha, McAuley, James, Limonne, Denis, Houze, Sandrine, Abraham, Sylvie, Piarroux, Raphael, Tesic, Vera, Beavis, Kathleen, Abeleda, Ana, Sautter, Mari, El Mansouri, Bouchra, El Bachir, Adlaoui, Amarir, Fatima, El Bissati, Kamal, de-la-Torre, Alejandra, Britton, Gabrielle, Motta, Jorge, Ortega-Barria, Eduardo, Romero, Isabel Luz, Meier, Paul, Grigg, Michael, Gómez-Marín, Jorge, Kosagisharaf, Jagannatha Rao, Llorens, Xavier Sáez, Reyes, Osvaldo, and McLeod, Rima

Published
2022
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4. Building Programs to Eradicate Toxoplasmosis Part II: Education

Author

Felín, Mariangela Soberón, Wang, Kanix, Moreira, Aliya, Grose, Andrew, Leahy, Karen, Zhou, Ying, Clouser, Fatima Alibana, Siddiqui, Maryam, Leong, Nicole, Goodall, Perpetua, Michalowski, Morgan, Ismail, Mahmoud, Christmas, Monica, Schrantz, Stephen, Caballero, Zuleima, Norero, Ximena, Estripeaut, Dora, Ellis, David, Raggi, Catalina, Castro, Catherine, Rengifo-Herrera, Claudia, Moossazadeh, Davina, Ramirez, Margarita, Pandey, Abhinav, Ashi, Kevin, Dovgin, Samantha, Dixon, Ashtyn, Li, Xuan, Begeman, Ian, Heichman, Sharon, Lykins, Joseph, Villalobos-Cerrud, Delba, Fabrega, Lorena, Montalvo, José Luis Sanchez, Mendivil, Connie, Quijada, Mario R., Fernández-Pirla, Silvia, de La Guardia, Valli, Wong, Digna, de Guevara, Mayrene Ladrón, Flores, Carlos, Borace, Jovanna, García, Anabel, Caballero, Natividad, de Saez, Maria Theresa Moreno, Politis, Michael, Ross, Stephanie, Dogra, Mimansa, Dhamsania, Vishan, Graves, Nicholas, Kirchberg, Marci, Mathur, Kopal, Aue, Ashley, Restrepo, Carlos M., Llanes, Alejandro, Guzman, German, Rebellon, Arturo, Boyer, Kenneth, Heydemann, Peter, Noble, A. Gwendolyn, Swisher, Charles, Rabiah, Peter, Withers, Shawn, Hull, Teri, Frim, David, McLone, David, Su, Chunlei, Blair, Michael, Latkany, Paul, Mui, Ernest, Vasconcelos-Santos, Daniel Vitor, Villareal, Alcibiades, Perez, Ambar, Galvis, Carlos Andrés Naranjo, Montes, Mónica Vargas, Perez, Nestor Ivan Cardona, Ramirez, Morgan, Chittenden, Cy, Wang, Edward, Garcia-López, Laura Lorena, Muñoz-Ortiz, Juliana, Rivera-Valdivia, Nicolás, Bohorquez-Granados, María Cristina, de-la-Torre, Gabriela Castaño, Padrieu, Guillermo, Hernandez, Juan David Valencia, Celis-Giraldo, Daniel, Dávila, John Alejandro Acosta, Torres, Elizabeth, Oquendo, Manuela Mejia, Arteaga-Rivera, José Y., Nicolae, Dan L., Rzhetsky, Andrey, Roizen, Nancy, Stillwaggon, Eileen, Sawers, Larry, Peyron, Francois, Wallon, Martine, Chapey, Emanuelle, Levigne, Pauline, Charter, Carmen, De Frias, Migdalia, Montoya, Jose, Press, Cindy, Ramirez, Raymund, Contopoulos-Ioannidis, Despina, Maldonado, Yvonne, Liesenfeld, Oliver, Gomez, Carlos, Wheeler, Kelsey, Zehar, Samantha, McAuley, James, Limonne, Denis, Houze, Sandrine, Abraham, Sylvie, Piarroux, Raphael, Tesic, Vera, Beavis, Kathleen, Abeleda, Ana, Sautter, Mari, El Mansouri, Bouchra, El Bachir, Adlaoui, Amarir, Fatima, El Bissati, Kamal, Holfels, Ellen, Penn, Richard, Cohen, William, de-la-Torre, Alejandra, Britton, Gabrielle, Motta, Jorge, Ortega-Barria, Eduardo, Romero, Isabel Luz, Meier, Paul, Grigg, Michael, Gómez-Marín, Jorge, Kosagisharaf, Jagannatha Rao, Llorens, Xavier Sáez, Reyes, Osvaldo, and McLeod, Rima

Published
2022
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7. Patterns of Hydrocephalus Caused by Congenital Toxoplasma gondii Infection Associate With Parasite Genetics.

Author

Hutson, Samuel L., Wheeler, Kelsey M., McLone, David, Frim, David, Penn, Richard, Swisher, Charles N., Heydemann, Peter T., Boyer, Kenneth M., Noble, A. Gwendolyn, Rabiah, Peter, Withers, Shawn, Montoya, Jose G., Wroblewski, Kristen, Karrison, Theodore, Grigg, Michael E., and McLeod, Rima

Subjects
HYDROCEPHALUS, CONGENITAL disorders, TOXOPLASMA gondii, TOXOPLASMOSIS, SEROTYPES, DISEASE risk factors
Abstract

Four anatomical patterns of hydrocephalus secondary to congenital Toxoplasma gondii infection were identified and characterized for infants enrolled in the National Collaborative Chicago-based Congenital Toxoplasmosis Study. Analysis of parasite serotype revealed that different anatomical patterns associate with Type-II vs Not-Exclusively Type-II strains (NE-II) (P = .035). [ABSTRACT FROM AUTHOR]

Published
2015
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8. Outcome of Treatment for Congenital Toxoplasmosis, 1981-2004: The National Collaborative Chicago-Based, Congenital Toxoplasmosis Study.

Author

McLeod, Rima, Boyer, Kenneth, Karrison, Theodore, Kasza, Kristen, Swisher, Charles, Roizen, Nancy, Jalbrzikowski, Jessica, Remington, Jack, Heydemann, Peter, Noble, A. Gwendolyn, Mets, Marilyn, Holfels, Ellen, Withers, Shawn, Latkany, Paul, and Meier, Paul

Subjects
MEDICAL research, HEALTH outcome assessment, THERAPEUTICS, TOXOPLASMOSIS, INFANTS, HUMAN abnormalities
Abstract

Background. Without treatment, congenital toxoplasmosis has recurrent, recrudescent, adverse outcomes. Long-term follow-up of infants with congenital toxoplasmosis treated throughout their first year of life with pyrimethamine and sulfadiazine has not been reported. Methods. Between 1981 and 2004, one hundred twenty infants (current mean age ± standard deviation, 10.5 ± 4.8 years) with congenital toxoplasmosis were treated with 1 of 2 doses of pyrimethamine plus sulfadiazine; therapy was initiated shortly after birth and continued for 12 months. Children who received treatment were evaluated at birth and at predetermined intervals; the focus of the evaluations was on prespecified end points: motor abnormalities, cognitive outcome, vision impairment, formation of new eye lesions, and hearing loss. Results. Treatment of infants without substantial neurologic disease at birth with pyrimethamine and sulfadiazine for 1 year resulted in normal cognitive, neurologic, and auditory outcomes for all patients. Treatment of infants who had moderate or severe neurologic disease (as defined in this article in the Treatments subsection of Methods) at birth resulted in normal neurologic and/or cognitive outcomes for 172% of the patients, and none had sensorineural hearing loss. Ninety-one percent of children without substantial neurologic disease and 64% of those with moderate or severe neurologic disease at birth did not develop new eye lesions. Almost all of these outcomes are markedly better than outcomes reported for children who were untreated or treated for 1 month in earlier decades (P<.01 to P<.001). Sex and severity of disease were comparable in our 2 treatment groups, and no significant differences in efficacy or toxicity were noted between the 2 treatment groups (P>.05). Conclusions. Although not all children did well with treatment, the favorable outcomes we noted indicate the importance of diagnosis and treatment of infants with congenital toxoplasmosis. [ABSTRACT FROM AUTHOR]

Published
2006

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