1. Morphometric comparison of foramen magnum in non-syndromic craniosynostosis patients with or without Chiari I malformation.
- Author
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Leikola, J., Haapamäki, V., Karppinen, A., Koljonen, V., Hukki, J., Valanne, L., and Koivikko, M.
- Subjects
MORPHOMETRICS ,MAGNETIC resonance imaging of the brain ,RADIOLOGY ,HUMAN abnormalities ,TOMOGRAPHY - Abstract
Background: In order to compare the morphometry of foramen magnum (FM) in a matched-pair study, in children with non-syndromic craniosynostosis with and without Chiari I malformation (CMI), both brain magnetic resonance (MRI) and multidetector computed tomography (MDCT) images were utilized. Methods: Brain MR images were retrieved from the Helsinki University Hospital Picture Archiving and Communications System to identify patients with CMI during 1.1.2004 to 31.3.2009. Age-, gender-, and craniosynostosis-matched controls were retrieved from the same cohort. Morphometric analysis of FM was carried out. Results: Seven patients with non-syndromic craniosynostosis with CMI were recorded. In CMI patients, the absolute anteroposterior length was 33.4 mm as compared to 36.7 mm in controls ( p = 0.023). The mean width was 28.1 and 29.9 mm ( p = 0.29), and the cross-sectional area was 654.1 and 764.9 mm ( p = 0.11) in CMI and controls, respectively. In CMI patients, the relative anteroposterior length of the FM was, on average, 91 % of the control's measurements. On average, the width was 95 % and the cross-sectional area was 88 % of the control's results. Conclusions: In pediatric non-syndromic craniosynostosis patients, a statistically significant reduced anteroposterior diameter of the FM is found in patients with an adjacent CMI as compared to their age-, gender-, and type-matched controls of craniosynostosis. [ABSTRACT FROM AUTHOR]
- Published
- 2012
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