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2 results on '"Kang-qing Zuo"'

1. Effect of Reaction Temperature on the Microstructure and Properties of Magnesium Phosphate Chemical Conversion Coatings on Titanium

Author

Yi-Bo Li, Yu-Peng Lu, Chun-Miao Du, Kang-Qing Zuo, Yu-Ying Wang, Kang-Le Tang, and Gui-Yong Xiao

Subjects
newberyite, phosphate chemical conversion, reaction temperature, titanium, Organic chemistry, QD241-441
Abstract

Magnesium phosphate (MgP) has garnered growing interest in hard tissue replacement processes due to having similar biological characteristics to calcium phosphate (CaP). In this study, an MgP coating with the newberyite (MgHPO4·3H2O) was prepared on the surface of pure titanium (Ti) using the phosphate chemical conversion (PCC) method. The influence of reaction temperature on the phase composition, microstructure, and properties of coatings was systematically researched with the use of an X-ray diffractometer (XRD), a scanning electron microscope (SEM), a laser scanning confocal microscope (LSCM), a contact angle goniometer, and a tensile testing machine. The formation mechanism of MgP coating on Ti was also explored. In addition, the corrosion resistance of the coatings on Ti was researched by assessing the electrochemical behavior in 0.9% NaCl solution using an electrochemical workstation. The results showed that temperature did not obviously affect the phase composition of the MgP coatings, but affected the growth and nucleation of newberyite crystals. In addition, an increase in reaction temperature had a great impact on properties including surface roughness, thickness, bonding strength, and corrosion resistance. Higher reaction temperatures resulted in more continuous MgP, larger grain size, higher density, and better corrosion resistance.

Published
2023
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2. Interleukin-4 assisted calcium-strontium-zinc-phosphate coating induces controllable macrophage polarization and promotes osseointegration on titanium implant

Author

Yu-peng Lu, Chao Liu, Kai Wang, Da-Wang Zhao, Gui-yong Xiao, Lei Cheng, Zhao-Yang Sun, and Kang-Qing Zuo

Subjects
Materials science, Biocompatibility, Surface Properties, Osteoimmunomodulation, Macrophage polarization, Bioengineering, 02 engineering and technology, engineering.material, 010402 general chemistry, 01 natural sciences, Osseointegration, Article, Phosphates, Biomaterials, Coating, Coated Materials, Biocompatible, In vivo, Osteogenesis, Animals, Orthopedic implants, Bone regeneration, Cells, Cultured, Titanium, Macrophages, Interleukin, 021001 nanoscience & nanotechnology, 0104 chemical sciences, Rats, Zinc, Mechanics of Materials, Strontium, Biophysics, engineering, Surface modification, Calcium, Interleukin-4, Calcium-strontium-zinc-phosphate coating, 0210 nano-technology
Abstract

Titanium (Ti) and its alloys are believed to be promising scaffold materials for dental and orthopedic implantation due to their ideal mechanical properties and biocompatibility. However, the host immune response always causes implant failures in the clinic. Surface modification of the Ti scaffold is an important factor in this process and has been widely studied to regulate the host immune response and to further promote bone regeneration. In this study, a calcium-strontium-zinc-phosphate (CSZP) coating was fabricated on a Ti implant surface by phosphate chemical conversion (PCC) technique, which modified the surface topography and element constituents. Here, we envisioned an accurate immunomodulation strategy via delivery of interleukin (IL)-4 to promote CSZP-mediated bone regeneration. IL-4 (0 and 40 ng/mL) was used to regulate immune response of macrophages. The mechanical properties, biocompatibility, osteogenesis, and anti-inflammatory properties were evaluated. The results showed that the CSZP coating exhibited a significant enhancement in surface roughness and hydrophilicity, but no obvious changes in proliferation or apoptosis of bone marrow mesenchymal stem cells (BMMSCs) and macrophages. In vitro, the mRNA and protein expression of osteogenic related factors in BMMSCs cultured on a CSZP coating, such as ALP and OCN, were significantly higher than those on bare Ti. In vivo, there was no enhanced bone formation but increased macrophage type 1 (M1) polarization on the CSZP coating. IL-4 could induce M2 polarization and promote osteogenesis of BMMSCs on CSZP in vivo and in vitro. In conclusion, the CSZP coating is an effective scaffold for BMMSCs osteogenesis, and IL-4 presents the additional advantage of modulating the immune response for bone regeneration on the CSZP coating in vivo., Highlights • A chemical conversion calcium-strontium-zinc-phosphate (CSZP) coating is prepared on titanium. • The CSZP coating exhibits micellar lamellar crystal morphology in micro-nano scale. • The CSZP coating has an optimal topography and element composition for osteogenesis. • Interleukin-4 assisted CSZP coating can obtain better osteoimmunomodulation properties.

Published
2020

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