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2. [In vivo antimycotic effect of topically applied morpholine (author's transl)].

Author

Kubis A, Witek R, Baran E, Jadach W, Matecka K, and Zaba A

Subjects
Administration, Topical, Animals, Guinea Pigs, Morpholines administration & dosage, Tinea pathology, Antifungal Agents, Morpholines therapeutic use, Tinea drug therapy
Abstract

The effect of morpholine in the cure of experimental mycosis caused by Trichophyton mentagrophytes var. granulosum was studied. In all experiments the ointment or gel containing 10% morpholine. The liberation constant of the ointment and gel was k = 1.243 x 10(--1) x k(--1) and k = 3.713 x 10(--1) x k(--1) respectively. After treatment with the ointment or gel on the guinea pig skin, a cure of mycosis was observed. The antimycotic effect of morpholine was demonstrated in histopathological, mycological and clinical study. The effect of morpholine was compared with cream Canesten "Polfa".

Published
1981

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