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In the operation using sevoflurane as an anesthetic, some patients, especially children, will have agitation symptoms after awakening from anesthesia. The incidence of agitation is about 20%, and current detection methods cannot predict the probability of a patient with agitation. In this paper, a magnetic field enhanced photoelectron ionization (MEPEI) miniature time-of-flight mass spectrometer (TOFMS) was developed for point-of-care detection and verification of the relationship between postoperative agitation symptoms and sevoflurane concentration in exhaled breath. The MEPEI source is water vapor resistant and can directly ionize sevoflurane via capillary sampling and obtain its characteristic ion [C4H3F6O]+ (m/z 181), and the analysis time of exhaled breath is only 60 s. Three standard curves of 0.5–80 ppmv, 80–2000 ppmv and 2000–15 000 ppmv were formulated to quantitatively detect sevoflurane in different scenarios, the coefficient of determination (R2) was higher than 0.9882 and the relative standard deviation (RSD) of signal intensity was only 1.24%. The results indicated that four of the 46 child patients had agitation symptoms. Partial least squares-discriminant analysis (PLS-DA) was performed to analyze the data, and an identification and treatment strategy was established for child patients with agitation symptoms. The new miniature MEPEI-TOFMS was also successfully used to evaluate the concentration of sevoflurane in a medical environment. The real-time monitoring of sevoflurane concentration in exhalation indicates the potential of this method for low-cost and convenient point-of-care (POC) detection and diagnosis of agitation symptoms. [ABSTRACT FROM AUTHOR]

Rationale Sulfur hexafluoride (SF6) gas-insulated switchgear (GIS) is an essential piece of electrical equipment in a substation, and the concentration of the SF6 decomposition products are directly relevant to the security and reliability of the substation. The detection of SF6 decomposition products can be used to diagnosis the condition of the GIS. Methods The decomposition products of SO2, SO2F2, and SOF2 were selected as indicators for the diagnosis. A suitcase time-of-flight mass spectrometer (TOFMS) was designed to perform online GIS failure analysis. An RF VUV lamp was used as the photoelectron ion source; the sampling inlet, ion einzel lens, and vacuum system were well designed to improve the performance. Results The limit of detection (LOD) of SO2 and SO2F2 within 200 s was 1 ppm, and the sensitivity was estimated to be at least 10-fold more sensitive than the previous design. The high linearity of SO2, SO2F2 in the range of 5-100 ppm has excellent linear correlation coefficient R2 at 0.9951 and 0.9889, respectively. Conclusions The suitcase TOFMS using orthogonal acceleration and reflecting mass analyzer was developed. It has the size of 663 × 496 × 338 mm and a weight of 34 kg including the battery and consumes only 70 W. The suitcase TOFMS was applied to analyze real decomposition products of SF6 inside a GIS and succeeded in finding out the hidden dangers. The suitcase TOFMS has wide application prospects for establishing an early-warning for the failure of the GIS. Copyright © 2016 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]

The dependence of multiply charged ions on laser ellipticity in methyl iodide clusters with 532 nm nanosecond laser was measured using a time-of-flight mass spectrometer. The intensities of multiply charged ions Iq+(q= 2–4) with circularly polarised laser pulse were clearly higher than those with linearly polarised laser pulse but the intensity of single charged ions I+was inverse. And the dependences of ions on the optical polarisation state were investigated and a flower petal and square distribution for single charged ions (I+, C+) and multiply charged ions (I2+, I3+, I4+, C2+) were observed, respectively. A theoretical calculation was also proposed to simulate the distributions of ions and theoretical results fitted well with the experimental ones. It indicated that the high multiphoton ionisation probability in the initial stage would result in the disintegration of big clusters into small ones and suppress the production of multiply charged ions. [ABSTRACT FROM AUTHOR]

A vacuum ultraviolet lamp based single photon ionization- (SPI-) photoelectron ionization (PEI) portable reflecting time-of-flight mass spectrometer (TOFMS) was designed for online monitoring gas samples. It has a dual mode ionization source: SPI for analyte with ionization energy (IE) below 10.6 eV and PEI for IE higher than 10.6 eV. Two kinds of sampling inlets, a capillary inlet and a membrane inlet, are utilized for high concentration and trace volatile organic compounds, respectively. A mass resolution of 1100 at m/z 64 has been obtained with a total size of 40 × 31 × 29 cm, the weight is 27 kg, and the power consumption is only 70 W. A mixture of benzene, toluene, and xylene (BTX), SO2, and discharging products of SF6 were used to test its performance, and the result showed that the limit of quantitation for BTX is as low as 5 ppbv (S/N = 10 : 1) with linear dynamic ranges greater than four orders of magnitude. The portable TOFMS was also evaluated by analyzing volatile organic compounds from wine and decomposition products of SF6 inside of a gas-insulated switchgear. [ABSTRACT FROM AUTHOR]

Formic and acetic acids are the most abundant gaseous organic acids and play the key role in the atmospheric chemistry. In iodine-adduct chemical ionization mass spectrometry (CIMS), the low utilization efficiency of methyl iodide and humidity interference are two major issues of the vacuum ultraviolet (VUV) lamp initiated CIMS for on-line gaseous formic and acetic acids analysis. In this work, we present a new CIMS based on VUV lamp, and the ion-molecular reactor is separated into photoionization and chemical ionization zones by a reducer electrode. Acetone was added to the photoionization zone, and the VUV photoionization acetone provided low-energy electrons for methyl iodide to generate I−, and the addition of acetone reduced the amount of methyl iodide by 2/3. In the chemical ionization zone, a headspace vial containing ultrapure water was added for humidity calibration, and the vial changes the sensitivity as a function of humidity from ambiguity to well linear correlation (R 2 > 0.95). With humidity calibration, the CIMS can quantitatively measure formic and acetic acids in the humidity range of 0%-88% RH. In this mode, limits of detection of 10 and 50 pptv are obtained for formic and acetic acids, respectively. And the relative standard deviation (RSD) of quantitation stability for 6 days were less than 10.5%. This CIMS was successfully used to determine the formic and acetic acids in the underground parking and ambient environment of the Shandong University campus (Qingdao, China). In addition, we developed a simple model based formic acid concentration to assess vehicular emissions. [Display omitted] [ABSTRACT FROM AUTHOR]

Ethane is the second largest component among natural gas, and the detection of ethane is an effective method for rapid identification of the leakage of the natural gas pipelines. In this work, a homogeneous sampling membrane inlet was developed and coupled with the homemade photoelectron ionization miniature time-of-flight mass spectrometer (PEI-mini-TOFMS) for in situ, on-line and highly sensitive ethane detection. The membrane area of the homogeneous sampling membrane inlet was increased from 490 mm2 to 1256 mm2, gaseous sample is injected from the top port and flowed through the membrane surface and out of the bottom two ports, with the three ports arranged in a triangular shape. The highest average flow velocity of the gas on the surface of the membrane reached 0.4 m s−1, and the optimal gas pressure in the PEI source was enhanced from 2.2 Pa to 4.0 Pa with this new design. The new design improved the comprehensive sensitivity of ethane by a factor of 3.0 compared with that of the traditional two-hole membrane inlet with the membrane area of 490 mm2. The semiconductor cold trap controlled the sample relative humidity (RH) at 10–12%, enabling direct sampling for highly sensitive analysis with RH as high as 70% and temperature from 7 °C to 40 °C. The quantitative range was 1–50 ppmv with a limit of detection (LOD, S/N = 3) lowered to 420 ppbv within 1 min, and zero humidity quantitative calibration with cold trap further reduced the relative standard deviation (RSD) of the signal intensities to 2.84%. The performance of the novel method developed in this work demonstrated a potential application on the above-ground natural gas pipelines leakage monitoring. [Display omitted] • A homogeneous sampling membrane inlet (HSMI) with three ports was developed to improve the enrichment efficiency. • The HSMI was coupled with the photoelectron ionization time-of-flight mass spectrometry (PEI-TOFMS) for ethane detection. • The HSMI improved ethane sensitivity by a factor of 3.0 compared with that of the traditional two-hole membrane inlet. • The ethane with different humidity can be quantitative analyzed by a home made semiconductor cold trap. • The MIPEI-mini-TOFMS has potential application in monitoring above-ground natural gas pipelines leakage. [ABSTRACT FROM AUTHOR]