1. Sweetened beverages are associated with a higher risk of differentiated thyroid cancer in the EPIC cohort: a dietary pattern approach.
- Author
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Zamora-Ros R, Cayssials V, Clèries R, Torrents M, Byrnes G, Weiderpass E, Sandström M, Almquist M, Boutron-Ruault MC, Tjønneland A, Kyrø C, Katzke VA, Le Cornet C, Masala G, Krogh V, Iannuzzo G, Tumino R, Milani L, Skeie G, Ubago-Guisado E, Amiano P, Chirlaque MD, Ardanaz E, Janzi S, Eriksson L, Freisling H, Heath AK, Rinaldi S, and Agudo A
- Subjects
- Adult, Humans, Sweetening Agents, Prospective Studies, Diet adverse effects, Beverages, Risk Factors, Sugar-Sweetened Beverages, Thyroid Neoplasms epidemiology, Thyroid Neoplasms etiology, Adenocarcinoma complications
- Abstract
Background: Dietary pattern analysis has gained particular interest, because it reflects the complexity of dietary intake. The aim of this study was to explore the associations between a posteriori dietary patterns, derived using a data-driven approach, and the risk of differentiated thyroid cancer (TC) in Europe., Methods: This investigation included 450,064 adults from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Dietary intake was assessed using validated country-specific dietary questionnaires. A posteriori dietary patterns were computed using principal component analyses. Cox regression was used to calculate multivariable adjusted hazard ratios (HRs) and 95% confidence intervals (CIs)., Results: After a mean follow-up time of 14 years, 712 first differentiated TCs were diagnosed. In the fully adjusted model, a dietary pattern characterized by alcohol consumption (basically beer and wine) was negatively associated with differentiated TC risk (HR
Q4vs.Q1 = 0.75; 95% CI:0.60-0.94, P-trend = 0.005), while a dietary pattern rich in sweetened beverages was positively associated with differentiated TC risk (HRQ4vs.Q1 = 1.26; 95% CI:0.99-1.61; P-trend = 0.07). The remaining 8 dietary patterns were not related to differentiated TC risk. The intake of sweetened beverages was positively associated with differentiated TC risk (HR100mL/d = 1.05; 95% CI:1.00-1.11), especially with papillary TC risk (HR100mL/d = 1.07; 95% CI:1.01-1.13). Similar results were observed with sugary and artificially sweetened beverages., Conclusions: The investigation of dietary patterns detected that the consumption of sweetened beverages was associated with a higher risk of differentiated thyroid cancer. Our results are in line with the general dietary recommendations of reducing the consumption of sweetened beverages., (© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany.)- Published
- 2023
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