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In a phase II study, daclizumab was given as single second-line agent to 62 patients with steroid-refractory acute graft-versus-host disease (aGVHD). Complete resolution of aGVHD was achieved in 68.8% of patients. This response rate was significantly associated with a lower number of involved organs and smaller extent of skin involvement. The 4-year event-free survival (EFS) was 54.6%. Grade ≥III aGVHD, ≥2 involved organs at baseline and patient age >18 years were independently associated with lower EFS. Daclizumab could be a suitable alternative treatment for aGVHD, particularly when limited to the skin or gastrointestinal tract. [ABSTRACT FROM AUTHOR]

Provides information on a study which discussed the treatment of adenovirus infection in patients undergoing allogeneic hematopoietic stem cell transplantation. Research patients and methods; Results in the treated and untreated groups; Risk factors for treatment failure.