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In recent years, the main quest of science has been the pioneering of the groundbreaking biomedical strategies needed for achieving a personalized medicine. Ribonucleic acids (RNAs) are outstanding bioactive macromolecules identified as pivotal actors in regulating a wide range of biochemical pathways. The ability to intimately control the cell fate and tissue activities makes RNA‐based drugs the most fascinating family of bioactive agents. However, achieving a widespread application of RNA therapeutics in humans is still a challenging feat, due to both the instability of naked RNA and the presence of biological barriers aimed at hindering the entrance of RNA into cells. Recently, material scientists' enormous efforts have led to the development of various classes of nanostructured carriers customized to overcome these limitations. This work systematically reviews the current advances in developing the next generation of drugs based on nanotechnology‐assisted RNA delivery. The features of the most used RNA molecules are presented, together with the development strategies and properties of nanostructured vehicles. Also provided is an in‐depth overview of various therapeutic applications of the presented systems, including coronavirus disease vaccines and the newest trends in the field. Lastly, emerging challenges and future perspectives for nanotechnology‐mediated RNA therapies are discussed. [ABSTRACT FROM AUTHOR]

Background: This study aimed to assess the efficacy and safety of a single‐stage procedure using single‐layer Pelnac and defatted avulsed skin for the management of degloving injuries of the forearm and hand. Methods: This is a prospective study conducted from March 2013 to May 2017. A total of 15 consecutive patients with degloving injuries of the forearm and hand were treated with a single‐stage procedure using single‐layer Pelnac and defatted avulsed skin as a split‐thickness skin graft. Post‐operatively, scheduled follow‐up was conducted. Results: The overall 'take' rate of the Pelnac dermal template and the skin graft was 85–100%. No infections, haematoma or seroma were observed during hospitalization and after discharge. At the final follow‐up, patients' subjective satisfaction with the aesthetic appearance of the grafted areas was, on average, 71.0 (SD 8.0, range 55–92). The Vancouver Scar Scale value was 2.1 (SD 1.8, range 1.0–5.5), representing a good result. The response of 'normal or near normal' to the sensory recovery was obtained for 13 patients and 'slight loss' for two patients. The average Disabilities of the Arm, Shoulder and Hand score was 21.2 (SD 13.5, range 0–53), and most patients (14/15) regained the ability to perform the daily activities without pain or restriction by tissue adhesion. Conclusion: This single‐stage procedure represents an effective technique for the management of degloving injuries of the forearm and hand and should be considered an alternative to other reconstructive procedures. [ABSTRACT FROM AUTHOR]