1. A low carbohydrate, high protein diet combined with celecoxib markedly reduces metastasis.
- Author
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Ho, Victor W., Hamilton, Melisa J., Dang, Ngoc-Ha Thi, Hsu, Brian E., Adomat, Hans H., Guns, Emma S., Weljie, Aalim, Samudio, Ismael, Bennewith, Kevin L., and Krystal, Gerald
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METASTASIS ,PROSTATE cancer ,BREAST cancer ,CELECOXIB ,CYCLOOXYGENASE 2 inhibitors ,LOW-carbohydrate diet ,LABORATORY mice ,TUMOR growth ,THERAPEUTICS - Abstract
We show herein using both a short-term breast cancer (4T1) and long-term prostate cancer (Transgenic Adenocarcinoma of the Mouse Prostate) mouse model that a combination of a low carbohydrate, high protein diet with celecoxib substantially reduces metastasis.We recently demonstrated that both murine and human carcinomas grow significantly slower in mice on low carbohydrate (CHO), high protein diets than on isocaloric Western diets and that a further reduction in tumor growth rates occur when the low CHO diets are combined with the cyclooxygenase-2 inhibitor, celecoxib. Following upon these studies, we asked herein what effect low CHO, high protein diets, with or without celecoxib, might have on tumor metastasis. In the highly metastatic 4T1 mouse mammary tumor model, a 15% CHO, high protein diet supplemented with celecoxib (1 g/kg chow) markedly reduced lung metastases. Moreover, in longer-term studies using male Transgenic Adenocarcinoma of the Mouse Prostate mice, which are predisposed to metastatic prostate cancer, the 15% CHO diet, with and without celecoxib (0.3 g/kg chow), gave the lowest incidence of metastases, but a more moderate 25% CHO diet containing celecoxib led to the best survival. Metabolic studies with 4T1 tumors suggested that the low CHO, high protein diets may be forcing tumors to become dependent on amino acid catabolism for survival/growth. Taken together, our results suggest that a combination of a low CHO, high protein diet with celecoxib substantially reduces metastasis. [ABSTRACT FROM AUTHOR]
- Published
- 2014
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