1. Efficacy of metacognitive training for depression as add‐on intervention for patients with depression in acute intensive psychiatric inpatient care: A randomized controlled trial.
- Author
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Hauschildt, Marit, Arlt, Sönke, Moritz, Steffen, Yassari, Amir H., and Jelinek, Lena
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THERAPEUTICS , *PILOT projects , *ATTITUDE (Psychology) , *EFFECT sizes (Statistics) , *MOTIVATION (Psychology) , *TREATMENT duration , *PATIENT satisfaction , *SEVERITY of illness index , *TREATMENT effectiveness , *PATIENTS' attitudes , *RANDOMIZED controlled trials , *COMPARATIVE studies , *PSYCHOLOGICAL tests , *NEUROPSYCHOLOGICAL tests , *PRE-tests & post-tests , *MENTAL depression , *CRITICAL care medicine , *STATISTICAL sampling , *COGNITIVE testing , *COGNITIVE therapy , *PSYCHIATRIC treatment , *LONGITUDINAL method , *EVALUATION - Abstract
Background: Metacognitive training for depression (D‐MCT) is a novel low‐intensity group training for economic treatment of depression. Previous studies demonstrate its efficacy in moderately depressed outpatients. The present study evaluated efficacy and patients' perspective of the D‐MCT in severely depressed psychiatric inpatients. Methods: In a randomized‐controlled trial, 75 individuals with a major depressive disorder (MDD) were allocated to D‐MCT versus euthymic therapy as add‐on (twice a week) to cognitive‐behavioural‐based (CBT) inpatient‐care. Depressive symptoms (HDRS, BDI), dysfunctional (meta)cognition (DAS, MCQ‐30) and subjective appraisal were assessed at baseline, 4 weeks (post) and 3 months (follow‐up). Results: Participants in both conditions showed a large decline in depression at post and follow‐up‐assessment. No superior add‐effect of D‐MCT versus active control emerged for depression severity on top of the inpatient care. However, among patients with a diagnosis of MDD with no (vs. at least one) comorbidity, D‐MCT participants showed a larger decline in depressive (meta‐)cognition at follow‐up with medium‐to‐large effect sizes. D‐MCT was evaluated as superior in overall appraisal, treatment preference, motivation and satisfaction. Limitations: The follow‐up time interval of 3 months may have been too short to detect long‐term effects. There is emerging evidence that modification of (meta)cognition unfolds its full effects only with time. Effects of CBT inpatient‐care on outcome parameters cannot be differentiated. Conclusions: Although D‐MCT as an add‐on was not superior in complete case analyses, results suggest greater benefit for patients with MDD and no comorbidity. D‐MCT proved feasible in acute‐psychiatric inpatient‐care and was highly accepted by patients. Future studies should investigate the role of modified (meta)cognition on long‐term treatment outcome, including dropout and relapse rates. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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