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Terahertz wave has a good ability to identify biomolecules due to its fingerprint spectrum characteristics. However, the minimum detectable limit of terahertz technology by the conventional tablet pressing method is on the order of milligrams, which cannot meet the application requirements of low concentration detection in the biomedical field—near or below micrograms. Here, we proposed a method to enhance the detection sensitivity by designing a metamaterial chip with the absorption-induced transparency (AIT) effect, which can enhance the interaction between terahertz waves and biomolecules and lower the detectable limit. Taking 7-methylguanine (7-MG) as an example, based on its terahertz characteristic absorption peak, we designed a split-ring resonator (SRR) metamaterial chip, which has the advantages of high sensitivity, unlabeled detection, fast response and simple measurement. Its quantitative detection limit can reach 6.30 μg, which is about 500 times smaller than that of the traditional tablet pressing method (2.95 mg). In addition, for methylated and unmethylated substances, the chip exhibits different frequency shifts, which also realizes the qualitative identification effectively. These results provide a reference for the rapid and accurate diagnosis of diseases associated with molecular methylation in clinical medicine. [ABSTRACT FROM AUTHOR]

This review considers glioma molecular markers in brain tissues and body fluids, shows the pathways of their formation, and describes traditional methods of analysis. The most important optical properties of glioma markers in the terahertz (THz) frequency range are also presented. New metamaterial-based technologies for molecular marker detection at THz frequencies are discussed. A variety of machine learning methods, which allow the marker detection sensitivity and differentiation of healthy and tumor tissues to be improved with the aid of THz tools, are considered. The actual results on the application of THz techniques in the intraoperative diagnosis of brain gliomas are shown. THz technologies' potential in molecular marker detection and defining the boundaries of the glioma's tissue is discussed. [ABSTRACT FROM AUTHOR]