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The purpose of this study was to see if the microalgae species Chlorella miniata possess an antioxidant and antiinflammatorypotential and to see if there is a correlation between the cultivation conditions and these potentials. For this purpose, cultivation of the algae under different growth conditions had been carried out; afterwards the soxhletextraction of the produced biomass had been completed. Lastly the assays of Trolox equivalent antioxidant capacity (TEAC), ferric reducing antioxidant capacity (FARP), total antioxidant capacity (TAO), xanthine oxidase inhibition, and hyaluronidase inhibition were studied using extracts of microalgae obtained from the different cultivation parameters. It's important to mention that this was the first study using these assays on species of Chlorella miniata and the first that utilized the cultivation parameters on microalgae. The results were, 22,91 mg/g algae TEAC, 776,70 mg/g algae gallic acid equivalent of FRAP and 37,07% xanthine oxidase inhibition with a concentration of 10,5 mg algae per ml ethanol, 65,39% of hyaluronidase inhibition with a concentration of 0,9 mg algae per ml ethanol. The effects of the cultivation parameters on these assays and the Lc MS/MS analyses for various phenolic compounds in the extracts were also a part of the study. [ABSTRACT FROM AUTHOR]

• Kinetic modeling and optimization of cultivation parameters were integrated. • Kinetic models assessed temperature and light intensity dependencies of growth rate. • Ratkowsky's square root and Monod-type models exhibited the best fit. • The optimum cultivation conditions were determined as 21 °C and 496 μmol m−2s-1. • Together with the light intensity, μ sharply increased up to 200 μmol m−2s-1. In this study, the effects of two highly variable factors, temperature ranging from 10–35 °C and light intensity from 98–1289 μmol m−2s-1, on the specific growth rate, μ , of a diatom, Phaeodactylum tricornutum, at a constant aeration rate of 3000 cm3 min-1 were elucidated. The choice of the adequate kinetic models describing the growth related to temperature and light intensity resulted in rapid determination of optimum growth conditions. Ratkowsky's square root model and Monod-type model were assessed as the most suitable expressions among the three temperature- and eight light intensity-dependent models, respectively, presenting the highest adjusted R2 and smallest average relative deviation (ARD) values by means of nonlinear least squares method. Also, among the kinetic model approaches utilized to verify the combined effects of temperature and light intensity, the temperature-dependent Ratkowsky model in conjunction with the Monod-type expression with the smallest ARD value (4.19 %) and a high adjusted R2 (0.9775) exhibited the best surface fit. The optimum cultivation temperature and light intensity conditions for the achieving maximum specific growth rate of P. tricornutum were determined as 21 °C and 496 μmol m−2s-1, respectively, by the help of the Central Composite Design (CCD) of the Response Surface Methodology (RSM). [ABSTRACT FROM AUTHOR]