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* The traditional surgical pathology assessment requires tissue to be removed from the patient, then processed, sectioned, stained, and interpreted by a pathologist using a light microscope. Today, an array of alternate optical imaging technologies allow tissue to be viewed at high resolution, in real time, without the need for processing, fixation, freezing, or staining. Optical imaging can be done in living patients without tissue removal, termed in vivo microscopy, or also in freshly excised tissue, termed ex vivo microscopy. Both in vivo and ex vivo microscopy have tremendous potential for clinical impact in a wide variety of applications. However, in order for these technologies to enter mainstream clinical care, an expert will be required to assess and interpret the imaging data. The optical images generated from these imaging techniques are often similar to the light microscopic images that pathologists already have expertise in interpreting. Other clinical specialists do not have this same expertise in microscopy, therefore, pathologists are a logical choice to step into the developing role of microscopic imaging expert. Here, we review the emerging technologies of in vivo and ex vivo microscopy in terms of the technical aspects and potential clinical applications. We also discuss why pathologists are essential to the successful clinical adoption of such technologies and the educational resources available to help them step into this emerging role. doi: 10.5858/arpa.2018-0298-RA), Optical imaging technologies have emerged as viable modalities for clinical diagnosis and patient management. A confluence of events has facilitated this progress: (1) the advancement and validation of technologies that [...]

Micrograph analysis and characterization is a key function of many materials laboratories supporting manufacturing, quality control, and R&D. While classic methods are subjective and resource intensive, advancements in capture technology [...]

During the last few decades, there have been major advancements in optical imaging techniques in both technology development and validation studies for use in clinical applications. These optical imaging techniques [...]