12 results on '"Elsässer, Albrecht"'
Search Results
2. Aortic valve replacement in Germany in 2019
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Gaede, Luise, Blumenstein, Johannes, Husser, Oliver, Liebetrau, Christoph, Dörr, Oliver, Grothusen, Christina, Eckel, Clemens, Al-Terki, Hani, Kim, Won-Keun, Nef, Holger, Tesche, Christian, Hamm, Christian W., Elsässer, Albrecht, Achenbach, Stephan, and Möllmann, Helge
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- 2021
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3. Transvascular transcatheter aortic valve implantation in 2017
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Gaede, Luise, Blumenstein, Johannes, Liebetrau, Christoph, Dörr, Oliver, Kim, Won-Keun, Nef, Holger, Husser, Oliver, Gülker, Jan, Elsässer, Albrecht, Hamm, Christian W., Achenbach, Stephan, and Möllmann, Helge
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- 2020
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4. Pacemaker implantation after TAVI: predictors of AV block persistence
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Gaede, Luise, Kim, Won-Keun, Liebetrau, Christoph, Dörr, Oliver, Sperzel, Johannes, Blumenstein, Johannes, Berkowitsch, Alexander, Walther, Thomas, Hamm, Christian, Elsässer, Albrecht, Nef, Holger, and Möllmann, Helge
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- 2017
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5. Trends in aortic valve replacement in Germany in 2015: transcatheter versus isolated surgical aortic valve repair
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Gaede, Luise, Blumenstein, Johannes, Kim, Won-Keun, Liebetrau, Christoph, Dörr, Oliver, Nef, Holger, Hamm, Christian, Elsässer, Albrecht, and Möllmann, Helge
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- 2017
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6. Comparison of the New-Generation Self-Expanding NAVITOR Transcatheter Heart Valve with Its Predecessor, the PORTICO, in Severe Native Aortic Valve Stenosis.
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Eckel, Clemens Enno, Kim, Won-Keun, Grothusen, Christina, Tiyerili, Vedat, Elsässer, Albrecht, Sötemann, Dagmar, Schlüter, Judith, Choi, Yeong-Hoon, Charitos, Efstratios I., Renker, Matthias, Hamm, Christian W., Dohmen, Guido, Möllmann, Helge, and Blumenstein, Johannes
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AORTIC stenosis ,HEART valves ,AORTIC valve ,AORTIC valve insufficiency ,HEART valve prosthesis implantation ,INFECTIVE endocarditis - Abstract
Background: Third-generation transcatheter heart valves (THVs) are designed to improve outcomes. Data on the new intra-annular self-expanding NAVITOR are scarce. Aims: The aim of this analysis was to compare outcomes between the PORTICO and the NAVITOR systems. Methods: Data from 782 patients with severe native aortic stenosis treated with PORTICO (n = 645) or NAVITOR (n = 137) from 05/2012 to 09/2022 were evaluated. The clinical and hemodynamic outcomes of 276 patients (PORTICO, n = 139; NAVITOR, n = 137) were evaluated according to VARC-3 recommendations. Results: Rates of postprocedural more-than-mild paravalvular leakage (PVL) were significantly lower for NAVITOR than for PORTICO (7.2% vs. 1.5%, p = 0.041). In addition, severe bleeding rates (27.3% vs. 13.1%, p = 0.005) and major vascular complications (5.8% vs. 0.7%, p = 0.036) were lower in the NAVITOR group. The mean gradients (7 vs. 8 mmHg, p = 0.121) and calculated aortic valve areas (1.90 cm
2 vs. 1.99 cm2 , p = 0.235) were comparable. Rates of PPI were similarly high in both groups (15.3 vs. 21.6, p = 0.299). Conclusions: The NAVITOR demonstrated favorable in-hospital procedural outcome data, with lower rates of relevant PVL, major vascular complications, and severe bleeding than its predecessor the PORTICO and preserved favorable hemodynamic outcomes. [ABSTRACT FROM AUTHOR]- Published
- 2023
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7. Prognostic Impact of the Get-with-the-Guidelines Heart-Failure Risk Score (GWTG-HF) after Transcatheter Aortic Valve Replacement in Patients with Low-Flow–Low-Gradient Aortic Valve Stenosis.
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Eckel, Clemens, Blumenstein, Johannes, Husser, Oliver, Sötemann, Dagmar, Grothusen, Christina, Schlüter, Judith, Becher, Marc, Nef, Holger, Elsässer, Albrecht, Nickenig, Georg, Möllmann, Helge, and Tiyerili, Vedat
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AORTIC stenosis ,DISEASE risk factors ,AORTIC valve ,PROGNOSIS ,HEART failure - Abstract
Objectives: This study examined the prognostic value of the get-with-the-guidelines heart-failure risk score (GWTG-HF) on mortality in patients with low-flow–low-gradient aortic valve stenosis (LFLG-AS) after transcatheter aortic valve implantation (TAVI). Background: Data on feasibility of TAVI and mortality prediction in the LFLG-AS population are scarce. Clinical risk assessment in this particular population is difficult, and a score has not yet been established for this purpose. Methods: A total of 212 heart failure (HF) patients with real LFLG-AS were enrolled. Patients were classified into low-risk (n = 108), intermediate-risk (n = 90) and high-risk (n = 14) groups calculated by the GWTG-HF score. Clinical outcomes of cardiovascular events according to Valve Academic Research Consortium (VARC-2) recommendations and composite endpoint of death and hospitalization for heart failure (HHF) were assessed at discharge and 1 year of follow-up. Results: Baseline parameters of the groups showed a median age of 81.0 years [77.0; 84.0] (79.0 vs. 82.0 vs. 86.0, respectively p < 0.001), median EuroSCORE II of 6.6 [4.3; 10.7] (5.5 vs. 7.2 vs. 9.1, p = 0.004) and median indexed stroke volume of 26.7 mL/m
2 [22.0; 31.0] (28.2 vs. 25.8 vs. 25.0, p = 0.004). The groups significantly differed at follow-up in terms of all-cause mortality (10.2 vs. 21.1 vs. 28.6%; p < 0.035). There was no difference in intrahospital event rate (VARC). Postprocedural mean gradients were lower in high-risk group (7.0 vs. 7.0 vs. 5.0 mmHg, p = 0.011). No differences in postprocedural aortic valve area (1.9 vs. 1.7 vs. 1.9 cm2 , p = 0.518) or rate of device failure (5.6 vs. 6.8 vs. 7.7%, p = 0.731) could be observed. After adjustment for known predictors, the GWTG score (HR 1.07 [1.01–1.14], p = 0.030) as well as pacemaker implantation (HR 3.97 [1.34–11.75], p = 0.013) turned out to be possible predictors for mortality. An increase in stroke volume index (SVI) was, in contrast, protective (HR 0.90 [0.83–0.97]; p = 0.006). Conclusions: The GWTG score may predict mortality after TAVI in LFLG-AS HF patients. Interestingly, all groups showed similar intrahospital event and mortality rates, independent of calculated mortality risk. Low SVI and new conduction disturbances associated with PPI after THV implantation had negative impact on mid-term outcome in post-TAVI HF-patients. [ABSTRACT FROM AUTHOR]- Published
- 2023
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8. Procedural Outcomes of a Self-Expanding Transcatheter Heart Valve in Patients with Porcelain Aorta.
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Eckel, Clemens, Blumenstein, Johannes, Grothusen, Christina, Tiyerili, Vedat, Elsässer, Albrecht, Dohmen, Guido, Zeckzer, Anna, Gaede, Luise, Choi, Yeong-Hoon, Charitos, Efstratios I., Hamm, Christian W., Kim, Won-Keun, Möllmann, Helge, and Renker, Matthias
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HEART valves ,CARDIAC patients ,HEART valve prosthesis implantation ,AORTA ,AORTIC stenosis ,RADIOEMBOLIZATION ,THERAPEUTIC embolization - Abstract
Background: Severe calcification of the ascending aorta increases the peri-operative risk for neurological complications in patients with severe aortic stenosis. Transcatheter aortic valve implantation (TAVI) seems to be an optimal treatment option in these patients. However, the impact of the extent of aortic calcification on procedural and neurological outcomes during TAVI is unclear. Methods: Data from 3010 patients with severe native aortic valve stenosis treated with ACURATE neo/neo2 from May 2012 to July 2022 were evaluated and matched by 2-to-1 nearest-neighbor matching to identify one patient with porcelain aorta (PA) (n = 492) compared with two patients without PA (n = 984). PA was additionally subdivided into circumferential (classic PA) (n = 89; 3.0%) and non-circumferential (partial PA) (n = 403; 13.4%) calcification. We compared outcomes according to VARC-3 criteria among patients with and without PA and identified predictors for occurrence of stroke in the overall population. Results: Technical success (88.5% vs. 87.4%, p = 0.589) and device success at 30 days (82.3% vs. 81.5%, p = 0.755) after transcatheter ACURATE neo/neo2 implantation according to VARC-3 definition was high and did not differ between non-calcified aortas or PA. The rate of in-hospital complications according to VARC-3-definitions was low in both groups. Rates of all stroke (3.2% (n = 31) vs. 2.6% (n = 13), p = 0.705) or transitory ischemic attacks (1.1% vs. 1.2%, p = 1.000) did not differ significantly. Thirty-day all-cause mortality did not differ (3.0% vs. 3.2%, RR 1.1; p = 0.775). Overall device migration/embolization (OR 5.0 [ 2.10 ; 11.87 ] ), severe bleeding (OR 1.79 [ 1.11 ; 2.89 ] ), and major structural cardiac complications (OR 3.37 [ 1.32 ; 8.57 ] ) were identified as independent predictors for in-hospital stroke in a multivariate analysis after implantation of ACURATE neo/neo2. Conclusion: A porcelain aorta does not increase the risk of neurological complications after transfemoral ACURATE neo/neo2 implantation. Based on these findings, transfemoral ACURATE neo/neo2 implantation is safe in these particularly vulnerable patients. [ABSTRACT FROM AUTHOR]
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- 2023
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9. Lower mortality in an all-comers aortic stenosis population treated with TAVI in comparison to SAVR.
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Möllmann, Helge, Husser, Oliver, Blumenstein, Johannes, Liebetrau, Christoph, Dörr, Oliver, Kim, Won-Keun, Nef, Holger, Tesche, Christian, Hamm, Christian W., Elsässer, Albrecht, Achenbach, Stephan, and Gaede, Luise
- Abstract
Background: Within the last years TAVI—especially transfemoral/transvascular TAVI—has proven to be a valuable therapeutic option for most patients suffering from AS. Here, we present the outcome of a complete dataset of all patients undergoing aortic valve replacement in Germany in 2018. Methods: The data of all aortic valve procedures performed in Germany in 2018 derive from the mandatory nationwide quality control program. Patients were stratified with a new version of the German Aortic valve score (AKL Score) divided in different risk stratification depending on the treatment with either a catheter based (TV-TAVI) or surgical (iSAVR) approach. In-hospital outcomes have been compared between the two approaches. Results: 19,317 transvascular (TV)–TAVI procedures were carried out. In contrast to this steady growth, the number of iSAVR andtransapical (TA) -TAVI procedures declined. In-hospital mortality after TV-TAVI (2.5%) was lower when compared to iSAVR (3.1%) as well as TA-TAVI (5.7%) in-hospital mortality after TV-TAVI was significantly lowest (Fig. 2) with an in-hospital mortality rate of 2.5%. TV-TAVI was the only approach with an observed vs. expected mortality ratio < 1 according to the used risk prediction model. Conclusion: TV-TAVI is more often performed and shows lower in-hospital mortality than iSAVR. TV-TAVI has replaced iSAVR as the gold-standard concerning in-hospital outcome in aortic stenosis management. [ABSTRACT FROM AUTHOR]
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- 2020
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10. Outcome after transvascular transcatheter aortic valve implantation in 2016.
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Gaede, Luise, Blumenstein, Johannes, Liebetrau, Christoph, Dörr, Oliver, Kim, Won-Keun, Nef, Holger, Husser, Oliver, Elsässer, Albrecht, Hamm, Christian W, and Möllmann, Helge
- Abstract
Aims We analysed the number of procedures, complications and in-hospital mortality rates of all patients undergoing transvascular transcatheter aortic valve implantation (TV-TAVI) in comparison to isolated surgical aortic valve replacement (iSAVR) from 2014 to 2016 in Germany. Methods and results All aortic valve procedures performed in Germany are mandatorily registered in a quality control program. More than 15 000 TV-TAVI procedures were performed in 2016 in Germany. Especially the number of post-procedural complications declined within the last few years, including new pacemaker implantations (2015: 12.6% vs. 2016: 11.4%, P=0.002) and vascular complications (2015: 8.5% vs. 2016: 7.1%; P< 0.001). Thus, in 2016 the overall in-hospital mortality rate after TV-TAVI was 2.6%, which is for the first time numerically below that of iSAVR, which was 2.9% (P=0.19). A stratified analysis according to the German aortic valve score shows a lower observed than expected in-hospital mortality rate for TV-TAVI (O/E 0.68). Additionally, the in-hospital mortality was significantly lower after TV-TAVI than after iSAVR in the very high- (11.3% vs. 23.6%; P< 0.001), in the high- (4.1% vs. 9.2%; P< 0.001) and in the intermediate-risk group (3.0% vs. 4.6%; P= 0.016) and was similar to that of iSAVR in low-risk patients (1.6% vs. 1.4%; P=0.4). Conclusion The overall in-hospital mortality after TV-TAVI was numerically lower than after iSAVR in 2016 for the first time. In the low risk group in-hospital mortality was similar, whereas in all other risk groups in-hospital mortality after TV-TAVI was significantly lower than after SAVR. This is likely to contribute to a redefinition of the standard of care in the future. [ABSTRACT FROM AUTHOR]
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- 2018
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11. Pacemaker implantation after TAVI: predictors of AV block persistence.
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Gaede, Luise, Kim, Won-Keun, Liebetrau, Christoph, Dörr, Oliver, Sperzel, Johannes, Blumenstein, Johannes, Berkowitsch, Alexander, Walther, Thomas, Hamm, Christian, Elsässer, Albrecht, Nef, Holger, and Möllmann, Helge
- Abstract
Aims: Approximately every fifth patient undergoing transcatheter aortic valve implantation (TAVI) requires a permanent pacemaker (PPM) after the procedure. The aim of this study was to analyse predictors of atrioventricular block III° (AVBIII) persistence with concurrent PPM dependency after TAVI. Methods and results: Between 2010 and 2015 a total of 1198 patients underwent TAVI at the Kerckhoff Heart and Thorax Center, Germany. After exclusion of patients with prior PPM ( n = 173) 14.7% ( n = 176) of the patients underwent PPM implantation after the procedure. Independent predictors of PPM implantation were pre-existing right bundle branch block (RBBB, p < 0.001) and implantation of a CoreValve prosthesis ( p < 0.001). A subgroup of patients with a newly implanted PPM ( n = 102) were followed-up for a median of 73 (IQR 62-85) days. The leading indication for PPM implantation was AVBIII in 74.5% (76/102). Of these patients only 22.4% (17/76) had persistent AVBIII at follow-up. Predictors of AVBIII persistence were prior RBBB ( p = 0.04), postdilatation ( p = 0.006) and higher mean aortic valve gradient prior to implantation ( p = 0.013). PPMs were implanted earlier in patients with persisting AVBIII [1 day (IQR0-2.5) vs. 4 days (IQR2-7); p < 0.001]. Early PPM implantation after TAVI was the only independent predictor of persistent AVBIII [OR 1.36 (95% 1.05-1.75); p = 0.02]. Conclusion: The long-term persistence of AVBIII is generally low after TAVI. Therefore, it may be wise to postpone the indication for PPM implantation for a couple of days. The only predictors of a lack of recovery of the AVB are prior RBBB, higher mean aortic valve gradients and postdilatation of the prosthesis. [ABSTRACT FROM AUTHOR]
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- 2018
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12. Correlation of tricuspid regurgitation and new pacemaker implantation in patients undergoing transcatheter aortic valve implantation.
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Schewel, Dimitry, Schewel, Jury, Schlüter, Michael, Kreidel, Felix, Schmidt, Tobias, Schmoeckel, Michael, Elsässer, Albrecht, Kuck, Karl-Heinz, and Frerker, Christian
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TRICUSPID valve insufficiency , *CARDIAC pacemakers , *AORTIC valve transplantation , *CHEMOEMBOLIZATION , *STATISTICAL correlation , *SURGERY - Abstract
Aims Conduction abnormalities (CA), in particular complete atrioventricular block (CAVB), requiring permanent pacemaker (PPM) implantation, are frequent complications after transcatheter aortic valve implantation (TAVI) in patients with severe aortic stenosis (AS). However, the potential mechanisms are still incompletely understood. The objective of this retrospective study was to determine further predictors of CAVB after TAVI in patients without the known predictors. Methods and results This study included patients without prior CA/PPM who underwent TAVI of a balloon-expandable valve (Sapien or Sapien XT or Sapien 3). Of 563 patients (81.2 ± 6.9 years, 245 men [43.5%], logistic EuroSCORE 22.2 ± 14.1%, STS PROM 5.9 [3.4–8.0]) who were treated by TAVI at our institution between July 2008 and January 2016, 61 (10.8%) developed a permanent CAVB after the procedure. In a multivariable logistic regression analysis moderate/severe tricuspid regurgitation (TR) (OR 2.05; 95% CI 1.18–3.55; p = 0.010) was identified as an independent predictor for new CAVB after TAVI. Moreover, patients with more pronounced TR presented with increased left and right ventricular overload (left ventricular (LV) end-diastolic diameter, LV end-diastolic pressure), pulmonary pressures, NT-proBNP, and prevalence of mitral regurgitation ≥II, whereas LV ejection fraction, TAPSE and cardiac output were decreased. Conclusions PPM implantation is a frequent complication in patients undergoing TAVI. Increasing severity of TR seems to be a consequence of left and right ventricular overload caused by severe AS and is a significant predictor of new CAVB after TAVI. Condensed abstract Conduction abnormalities (CA) requiring permanent pacemaker (PPM) implantation, are frequent complications after transcatheter aortic valve implantation (TAVI). This study included patients without prior CA/PPM who underwent TAVI. Of 563 patients 61 (10.8%) developed a permanent CAVB after the procedure. In a multivariable logistic regression analysis moderate/severe tricuspid regurgitation (TR) (OR 2.05; 95% CI 1.18–3.55; p = 0.010) was identified as an independent predictor for new CAVB. Therefore, in patients with moderate/severe TR utmost care should be taken to avoid procedural factors conducive to mechanical irritation of the conduction system, resulting in pacemaker dependency. [ABSTRACT FROM AUTHOR]
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- 2018
- Full Text
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