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Your search keyword '"Macomber, Alyssa"' showing total 2 results
Start Over Author "Macomber, Alyssa" Topic tau proteins
2 results on '"Macomber, Alyssa"'

1. Distinct Patterns of Hippocampal Pathology in Alzheimer's Disease with Transactive Response DNA‐binding Protein 43.

Author

Minogue, Grace, Kawles, Allegra, Zouridakis, Antonia, Keszycki, Rachel, Macomber, Alyssa, Lubbat, Vivienne, Gill, Nathan, Mao, Qinwen, Flanagan, Margaret E., Zhang, Hui, Castellani, Rudolph, Bigio, Eileen H., Mesulam, M.‐Marsel, Geula, Changiz, and Gefen, Tamar

Subjects
ALZHEIMER'S disease, DNA-binding proteins, FRONTOTEMPORAL lobar degeneration, DENTATE gyrus, HIPPOCAMPUS (Brain), MOLECULAR pathology, TAU proteins
Abstract

Objective: Age‐related dementia syndromes are often not related to a single pathophysiological process, leading to multiple neuropathologies found at autopsy. An amnestic dementia syndrome can be associated with Alzheimer's disease (AD) with comorbid transactive response DNA‐binding protein 43 (TDP‐43) pathology (AD/TDP). Here, we investigated neuronal integrity and pathological burden of TDP‐43 and tau, along the well‐charted trisynaptic hippocampal circuit (dentate gyrus [DG], CA3, and CA1) in participants with amnestic dementia due to AD/TDP, amnestic dementia due to AD alone, or non‐amnestic dementia due to TDP‐43 proteinopathy associated with frontotemporal lobar degeneration (FTLD‐TDP). Methods: A total of 48 extensively characterized cases (14 AD, 16 AD/TDP, 18 FTLD‐TDP) were analyzed using digital HALO software (Indica Labs, Albuquerque, NM, USA) to quantify pathological burden and neuronal loss. Results: In AD/TDP and FTLD‐TDP, TDP‐43 immunoreactivity was greatest in the DG. Tau immunoreactivity was significantly greater in DG and CA3 in AD/TDP compared with pure AD. All clinical groups showed the highest amounts of neurons in DG, followed by CA3, then CA1. The AD and AD/TDP groups showed lower neuronal counts compared with the FTLD‐TDP group across all hippocampal subregions consistent with the salience of the amnestic phenotype. Interpretation: We conclude that AD/TDP can be distinguished from AD and FTLD‐TDP based on differential regional distributions of hippocampal tau and TDP‐43. Findings suggest that tau aggregation in AD/TDP might be enhanced by TDP‐43. ANN NEUROL 2023;94:1036–1047 [ABSTRACT FROM AUTHOR]

Published
2023
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2. Interactive effects of pulse pressure and tau imaging on longitudinal cognition

Author

Weigand, Alexandra J., Macomber, Alyssa J., Walker, Kayla S., Edwards, Lauren, Thomas, Kelsey R., Bangen, Katherine J., Nation, Daniel A., and Bondi, Mark W.

Subjects
Amyloid beta-Peptides, Cognition, Alzheimer Disease, Positron-Emission Tomography, Humans, Blood Pressure, Cognitive Dysfunction, tau Proteins, Article, Biomarkers, Aged
Abstract

BACKGROUND: Studies have demonstrated that both tau and cardiovascular risk are associated with cognitive decline, but the possible synergistic effects of these pathologic markers remain unclear. OBJECTIVE: To explore the interaction of AD biomarkers with a specific vascular risk marker (pulse pressure, or PP) on longitudinal cognition. METHODS: Participants included 139 older adults from the Alzheimer’s Disease Neuroimaging Initiative (ADNI). Biomarkers of tau, amyloid-β (Aβ), and vascular risk (PP) were assessed. Neuropsychological assessment provided memory, language, and executive function domain composite scores at baseline and 1-year follow-up. Multiple linear regression examined interactive effects of PP with (1) tau PET independent of Aβ PET and (2) Aβ PET independent of tau PET on baseline and 1-year cognitive outcomes. RESULTS: The interaction between pulse pressure and tau PET significantly predicted 1-year memory performance such that the combined effect of high pulse pressure and high tau PET levels was associated with lower memory at follow-up but not at baseline. In contrast, Aβ PET did not significantly interact with pulse pressure to predict baseline or 1-year outcomes in any cognitive domain. Main effects revealed a significant effect of tau PET on memory, and no significant effects of Aβ PET or pulse pressure on any cognitive domain. CONCLUSION: Results indicate that tau and an indirect marker of arterial stiffening (PP) may synergistically contribute to memory decline, whereas Aβ may have a lesser role in predicting cognitive progression. Tau and vascular pathology (particularly in combination) may represent valuable targets for interventions intended to slow cognitive decline.

Published
2022

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