1. Decreased B Cells on Admission Associated With Prolonged Viral RNA Shedding From the Respiratory Tract in Coronavirus Disease 2019: A Case-Control Study
- Author
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Shaorui Hao, Shufa Zheng, Jifang Sheng, Tingbo Liang, Dairong Xiang, Liang Yu, Xiaopeng Yu, Yingfeng Lu, Hong Zhao, Yida Yang, Jianhua Hu, Qin Ni, Xiaoyan Wang, Xuan Zhang, Yongtao Li, Kaijin Xu, Jiangshan Lian, Lanjuan Li, Guodong Yu, Jun Liu, Yu Chen, Yunqing Qiu, and Hongyu Jia
- Subjects
Male ,0301 basic medicine ,Time Factors ,Respiratory System ,Gastroenterology ,0302 clinical medicine ,Risk Factors ,Interquartile range ,Immunology and Allergy ,030212 general & internal medicine ,Respiratory system ,B-Lymphocytes ,biology ,Brief Report ,Middle Aged ,Virus Shedding ,AcademicSubjects/MED00290 ,Infectious Diseases ,medicine.anatomical_structure ,Real-time polymerase chain reaction ,Quartile ,IL-10 ,Cytokines ,RNA, Viral ,Female ,Coronavirus Infections ,viral RNA shedding ,China ,medicine.medical_specialty ,Pneumonia, Viral ,T cells ,Real-Time Polymerase Chain Reaction ,Betacoronavirus ,03 medical and health sciences ,Internal medicine ,medicine ,Humans ,AcademicSubjects/MED00860 ,Lymphocyte Count ,Viral shedding ,Pandemics ,Proportional Hazards Models ,Retrospective Studies ,B cells ,SARS-CoV-2 ,business.industry ,Case-control study ,COVID-19 ,biology.organism_classification ,Logistic Models ,030104 developmental biology ,Case-Control Studies ,business ,Respiratory tract - Abstract
The viral RNA shedding time (VST) for severe acute respiratory syndrome coronavirus 2 has not been well characterized. Clinical data were collected and compared between patients with short and long VSTs (in the lower and upper quartiles, respectively). The probability of recurrent positive reverse-transcription polymerase chain reaction results decreased sharply to 4.8% after 3 consecutive negative results. A series of ≥3 consecutive negative results was suitable as a criterion for the end of viral RNA shedding. The VST for shedding from the respiratory tract was significantly shorter in patients with normal B-cell counts on admission than in those with decreased B-cell counts (median [interquartile range], 11 [9–13] vs 16 [12–20] days, respectively; P = .001).
- Published
- 2020