11 results on '"Leodori, Giorgia"'
Search Results
2. Serum resistin is predictive marker of development of new digital ulcers in systemic sclerosis
- Author
-
Pellicano, Chiara, Leodori, Giorgia, Colalillo, Amalia, Navarini, Luca, Gigante, Antonietta, and Rosato, Edoardo
- Published
- 2022
- Full Text
- View/download PDF
3. Estimated glomerular filtration rate is a marker of mortality in the European Scleroderma Trials and Research Group (EUSTAR) database
- Author
-
Gigante, Antonietta, Hoffmann-Vold, Anna-Maria, Fegatelli, Danilo Alunni, Gabrielli, Armando, Leodori, Giorgia, Coleiro, Bernard, De Santis, Maria, Dagna, Lorenzo, Alegre-Sancho, Juan Jose, Montecucco, Carlomaurizio, Carreira, Patricia E, Balbir-Gurman, Alexandra, Doria, Andrea, Riemekasten, Gabriela, Airò, Paolo, Distler, Jörg H W, Distler, Oliver, Rosato, Edoardo, EUSTAR collaborators, and University of Zurich
- Subjects
Adult ,Male ,0301 basic medicine ,systemic sclerosis ,Scleroderma Renal Crisis ,Renal function ,610 Medicine & health ,computer.software_genre ,Scleroderma ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Rheumatology ,Predictive Value of Tests ,Risk Factors ,medicine ,Humans ,Pharmacology (medical) ,In patient ,Risk factor ,030203 arthritis & rheumatology ,EUSTAR ,Creatinine ,Scleroderma, Systemic ,Database ,Proportional hazards model ,business.industry ,Incidence ,10051 Rheumatology Clinic and Institute of Physical Medicine ,glomerular filtration rate ,scleroderma renal crisis ,Middle Aged ,medicine.disease ,Pulmonary hypertension ,Survival Rate ,030104 developmental biology ,chemistry ,Female ,business ,computer ,Glomerular Filtration Rate - Abstract
Objectives The study aim was to evaluate the estimated glomerular filtration rate (eGFR), its association with clinical disease and its predictive ability with respect to mortality in SSc patients from the European Scleroderma Trials and Research Group (EUSTAR) database. Methods SSc patients from the EUSTAR database who had items required for the calculation of eGFR at a baseline visit and a second follow-up visit available were included. A cut-off eGFR value of 60 ml/min was chosen for all SSc patients, and 30 ml/min for those with scleroderma renal crisis (SRC). Cox regression and competing risk analysis were performed to evaluate the use of eGFR as a predictive factor of mortality. Results A total of 3650 SSc patients were included in this study. The median serum level of creatinine and the mean of eGFR were 0.8 mg/dl (interquartile range = 0.6–0.9) and 86.6 ± 23.7 ml/min, respectively. The eGFR was significantly lower in patients with pulmonary hypertension. Overall survival (OS) was significantly reduced in SSc patients with eGFR 30 ml/min and those with eGFR Conclusion eGFR represents a predictive risk factor for overall survival in SSc. The eGFR, however, does not represent a risk factor for death in SRC.
- Published
- 2021
4. Serum Adiponectin, a Novel Biomarker Correlates with Skin Thickness in Systemic Sclerosis.
- Author
-
Leodori, Giorgia, Pellicano, Chiara, Basile, Valerio, Colalillo, Amalia, Navarini, Luca, Gigante, Antonietta, Gulli, Francesca, Marino, Mariapaola, Basile, Umberto, and Rosato, Edoardo
- Subjects
- *
SYSTEMIC scleroderma , *ADIPONECTIN , *MULTIPLE regression analysis , *BIOMARKERS , *DISEASE duration - Abstract
The aim was to evaluate the longitudinal association between basal serum adiponectin and repeated measurements of skin thickness during 12 months of follow-up in systemic sclerosis (SSc) patients. We enrolled SSc patients with disease duration > 2 years in a prospective observational study. Skin thickness was measured at baseline and after 12 months of follow-up with modified Rodnan skin score (mRSS). Baseline serum adiponectin was determined using a commercial ELISA kit. We enrolled 66 female SSc patients (median age 54 years, IQR 42–62 years). The median disease duration was 12 (IQR 8–16) years and median baseline serum adiponectin was 9.8 (IQR 5.6–15.6) mcg/mL. The median mRSS was 10 (IQR 6–18) at baseline and 12 (IQR 7–18) at follow-up. A significant correlation was observed between baseline serum adiponectin and disease duration (r = 0.264, p < 0.05), age (r = 0.515, p < 0.0001), baseline mRSS (r = −0.303, p < 0.05), and mRSS at follow-up (r = −0.322, p < 0.001). In multiple regression analysis, only mRSS at follow-up showed an inverse correlation with baseline serum adiponectin (β = −0.132, p < 0.01). The reduction in serum adiponectin levels is correlated with skin thickness. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
5. In systemic sclerosis, the TAPSE/sPAP ratio can be used in addition to the DETECT algorithm for pulmonary arterial hypertension diagnosis.
- Author
-
Colalillo, Amalia, Grimaldi, Maria Chiara, Vaiarello, Valentina, Pellicano, Chiara, Leodori, Giorgia, Gigante, Antonietta, Romaniello, Antonella, and Rosato, Edoardo
- Subjects
EVALUATION of medical care ,CARDIAC catheterization ,MULTIPLE regression analysis ,SYSTEMIC scleroderma ,MEDICAL screening ,ELECTROCARDIOGRAPHY ,DESCRIPTIVE statistics ,ALGORITHMS ,EARLY diagnosis - Abstract
Objective Early detection of pulmonary arterial hypertension (PAH) is crucial for improving patient outcomes. The aim of this study was to compare the positive predictive value (PPV) of the echocardiography-derived tricuspid annular plane systolic excursion/systolic pulmonary artery pressure (TAPSE/sPAP) ratio with that of the DETECT algorithm for PAH screening in a cohort of SSc patients. Methods Fifty-one SSc patients were screened for PAH using the DETECT algorithm and echocardiography. Results Echocardiography was recommended by the DETECT algorithm step 1 in 34 patients (66.7%). Right heart catheterization (RHC) was recommended by the DETECT algorithm step 2 in 16 patients (31.4%). PAH was confirmed by RHC in 5 patients. The DETECT algorithm PPV was 31.3%. The TAPSE/sPAP ratio was higher in SSc patients not referred for RHC than in SSc patients referred for RHC according to the DETECT algorithm step 2 [0.83 (0.35–1.40) mm/mmHg vs 0.74 (0.12–1.09) mm/mmHg, P < 0.05]. Using a cut-off of 0.60 mm/mmHg, 8 (15.7%) SSc patients had a TAPSE/sPAP ratio of ≤0.60 mm/mmHg. PAH was confirmed by RHC in 5 patients. The PPV of TAPSE/sPAP was 62.5%. In multiple regression analysis, TAPSE/sPAP was associated with age [ β coefficient = −0.348 (95% CI: −0.011, −0.003); P < 0.01], DETECT algorithm step 1 [ β coefficient = 1.023 (95% CI: 0.006, 0.024); P < 0.01] and DETECT algorithm step 2 (β coefficient = −1.758 [95% CI: −0.059, −0.021]; P < 0.0001). Conclusion In SSc patients with a DETECT algorithm step 2 total score of >35, the TAPSE/sPAP ratio can be used to further select patients requiring RHC to confirm PAH diagnosis. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
6. Estimated glomerular filtration rate is a marker of mortality in the European Scleroderma Trials and Research Group (EUSTAR) database.
- Author
-
Gigante, Antonietta, Hoffmann-Vold, Anna-Maria, Fegatelli, Danilo Alunni, Gabrielli, Armando, Leodori, Giorgia, Coleiro, Bernard, Santis, Maria De, Dagna, Lorenzo, Alegre-Sancho, Juan Jose, Montecucco, Carlomaurizio, Carreira, Patricia E, Balbir-Gurman, Alexandra, Doria, Andrea, Riemekasten, Gabriela, Airò, Paolo, Distler, Jörg, Distler, Oliver, Rosato, Edoardo, and collaborators, the EUSTAR
- Subjects
GLOMERULAR filtration rate ,PATIENT aftercare ,BLOOD pressure ,PREDICTIVE tests ,CONFIDENCE intervals ,PULMONARY hypertension ,MULTIVARIATE analysis ,SYSTEMIC scleroderma ,PULMONARY artery ,RISK assessment ,SEX distribution ,DESCRIPTIVE statistics ,MEDICAL appointments ,DEATH ,PROPORTIONAL hazards models ,CREATININE ,DISEASE complications - Abstract
Objectives The study aim was to evaluate the estimated glomerular filtration rate (eGFR), its association with clinical disease and its predictive ability with respect to mortality in SSc patients from the European Scleroderma Trials and Research Group (EUSTAR) database. Methods SSc patients from the EUSTAR database who had items required for the calculation of eGFR at a baseline visit and a second follow-up visit available were included. A cut-off eGFR value of 60 ml/min was chosen for all SSc patients, and 30 ml/min for those with scleroderma renal crisis (SRC). Cox regression and competing risk analysis were performed to evaluate the use of eGFR as a predictive factor of mortality. Results A total of 3650 SSc patients were included in this study. The median serum level of creatinine and the mean of eGFR were 0.8 mg/dl (interquartile range = 0.6–0.9) and 86.6 ± 23.7 ml/min, respectively. The eGFR was significantly lower in patients with pulmonary hypertension. Overall survival (OS) was significantly reduced in SSc patients with eGFR < 60 ml/min compared with patients with eGFR ≥ 60 ml/min [OS at 5 years 0.763 (95% CI: 0.700, 0.814) vs 0.903 (95% CI: 0.883, 0.919; P < 0.001)]. In multivariable analysis, OS was associated with male gender (P < 0.01), systolic pulmonary arterial pressure (sPAP) (P < 0.001) and eGFR (P < 0.001). The cumulative incidence of deaths due to SSc was associated with increased sPAP (P < 0.001) and reduced eGFR (P < 0.05). The OS at 5 years of 53 SRC patients was not significantly different between SSc patients with eGFR > 30 ml/min and those with eGFR <30 ml/min. Conclusion eGFR represents a predictive risk factor for overall survival in SSc. The eGFR, however, does not represent a risk factor for death in SRC. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
7. Serum and urine free light chains measurements in patients with systemic sclerosis: novel biomarkers for disease activity.
- Author
-
Gigante, Antonietta, Pellicano, Chiara, Leodori, Giorgia, Napodano, Cecilia, Vantaggio, Lorenzo, Gulli, Francesca, Marino, Mariapaola, Visentini, Marcella, Rosato, Edoardo, and Basile, Umberto
- Subjects
SYSTEMIC scleroderma ,PHOTOMETRY ,URINE ,C-reactive protein ,BIOMARKERS ,MONOCLONAL gammopathies ,PLASMA cell diseases - Abstract
Summary: Circulating free light chains (FLCs), considered biomarkers of B cell activity, are frequently elevated in patients affected by systemic inflammatory autoimmune diseases. As the systemic sclerosis (SSc) clinical course can be variable, this study is aimed at evaluating FLCs levels in affected individuals as biomarkers of disease activity. We assessed FLC levels in serum and urine of 72 SSc patients and 30 healthy controls (HC). Results were analyzed in comparison with overall clinical and laboratory findings, disease activity index (DAI) and disease severity scale (DSS). SSc patients displayed increased levels of κ and λ FLC in serum significantly higher than HC (p = 0.0001) alongside the mean values of free κ/λ ratio and κ + λ sum (p = 0.0001). SSc patients showed increased free κ in urine with a κ/λ higher than HC (p = 0.0001). SSc patients with increased κ + λ in serum showed that erythro‐sedimentation rate (p = 0.034), C‐reactive protein (p = 0.003), DAI (p = 0.024) and DSS (p = 0.015) were higher if compared to SSc patients with normal levels of FLC. A positive linear correlation was found between serum levels of free κ and DAI (r = 0.29, p = 0.014). In addition, SSc patients with increased free κ in urine had higher DAI (p = 0.048) than SSc patients with normal κ levels. Our results strengthen the role of serum FLC as useful biomarker in clinical practice to early diagnosis and monitor disease activity, showing for the first time that also urine FLC levels correlated with disease activity in SSc patients. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
8. CD21low B cells are predictive markers of new digital ulcers in systemic sclerosis.
- Author
-
Visentini, Marcella, Pellicano, Chiara, Leodori, Giorgia, Marrapodi, Ramona, Colantuono, Stefania, Gigante, Antonietta, Casato, Milvia, and Rosato, Edoardo
- Subjects
B cells ,SYSTEMIC scleroderma ,ULCERS ,BLOOD cells ,RAYNAUD'S disease - Abstract
Summary: The objective of this study was to evaluate the predictive role of CD21low B cells as markers of new digital ulcers in systemic sclerosis patients. Peripheral blood B cell subpopulations and clinical assessments have been evaluated in 74 systemic sclerosis patients at baseline and after a 12‐month follow‐up. After a 12‐month follow‐up, 23 (31.1%) systemic sclerosis patients developed new digital ulcers. The median percentage of CD21low B cells was significantly higher in patients with than without new digital ulcers [10.1 (4.3–13.6) versus 4.8 (3.5–7.4); p < 0.01]. The 10% cut‐off shows good diagnostic accuracy [area under the curve (AUC) = 0.732, confidence interval (CI) = 0.587–0.878; P = 0.01]. Kaplan–Meier curves show a significantly reduced free survival from new digital ulcers in systemic sclerosis patients with CD21low B cells ≥ 10% (p < 0.0001). In multivariate analysis, CD21low B cells ≥ 10%, modified Rodnan skin score (mRSS) and systolic pulmonary arterial pressure (sPAP) are associated with the development of new digital ulcers. We hypothesize that CD21low B cells are a predictive marker of new digital ulcers in systemic sclerosis patients. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
9. Estimated glomerular filtration rate and renal resistive index as possible predictive markers of mortality in systemic sclerosis.
- Author
-
Leodori, Giorgia, Pellicano, Chiara, Gigante, Antonietta, and Rosato, Edoardo
- Subjects
- *
GLOMERULAR filtration rate , *SYSTEMIC scleroderma , *CHRONIC kidney failure , *PULMONARY artery , *MORTALITY - Abstract
• CKD-EPI is accurate formula to estimate glomerular filtration rate in SSc patients. • Renal resistive index is a marker of vascular damage in SSc patients. • eGFR is a predictive marker of mortality for SSc and all causes. • RRI is a predictive marker of mortality for all causes. Subclinical nephropathy is underestimated in systemic sclerosis (SSc). Study aim is to evaluate the role of renal resistance indices (RRI) and estimated glomerular filtration rate (eGFR) assessed by Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) as predictive markers of mortality during 10 years of follow-up in SSc patients. 181 SSc patients (60 years, 152 females) were enrolled. At baseline, the GFR was estimated in 181 SSc patients and RRI was measured in 122 SSc patients. During a follow-up of 10 years we recorded the main complications of disease, date and causes of death. eGFR shows a linear negative correlation with RRI. RRI showed a correlation with systolic pulmonary artery pressure (sPAP). Overall survival is lower in SSc patients with eGFR<60 ml/min and RRI ≥0.70 than in SSc patients with eGFR≥60 ml/min (p<0.0001) and with RRI<0.70 (p<0.01) both for mortality due to SSc and all causes. In multivariate analysis, eGFR<60 ml/min [HR 6.429, 95%CI (1.006-41.08), p <0.05] and forced vital capacity (FVC) [HR 0.954, 95%CI (0.911-1), p <0.05] are predictive markers of mortality due to SSc, while eGFR [HR 3.617, 95%CI (1.370-9.554), p <0.01], RRI [HR 0.210, 95% CI (0.068-0.649), p<0.01], age [HR 1.062, 95%CI (1.023-1.103), p <0.01], FVC [HR 0.967, 95%CI (0.946-0.989), p<0.01] and disease activity index (DAI) [HR 1.663, 95%CI (1.262-2.191), p <0.0001] are predictive markers of mortality due to all causes. We demonstrate that eGFR is a predictive marker of mortality due to SSc and to all causes, conversely RRI is predictive marker of mortality due to all causes. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
10. Color Doppler Ultrasonography of digital arteries and digital ulcers development in systemic sclerosis.
- Author
-
Colalillo, Amalia, Vaiarello, Valentina, Pellicano, Chiara, Leodori, Giorgia, Gigante, Antonietta, and Rosato, Edoardo
- Subjects
- *
COLOR Doppler ultrasonography , *SYSTEMIC scleroderma , *ARTERIES , *ULCERS - Abstract
The aim of this study was to evaluate the role of Color Doppler Ultrasonography (CDUS) of proper palmar digital arteries (PPDA) as predictive marker of new digital ulcers (DUs) in systemic sclerosis (SSc) patients during 5 years follow-up. 36 SSc patients were examined using nailfold videocapillaroscopy (NVC) and CDUS of PPDA. Fourteen (38.9%) patients had chronic or acute occlusions (C and D pattern) on CDUS evaluation. Using a cut-off of 0.70, 21 (58.3%) patients had a Resistive Index (RI) ≥0.70. Nineteen (52.8%) patients developed new DUs during the follow-up. The median value of RI was higher in SSc patients with DUs than in SSc patients without DUs [0.73 (IQR 0.70–0.81) vs 0.67 (IQR 0.57–0.70), p < 0.0001]. The Kaplan-Meier analysis showed a free survival from new DUs higher (p < 0.01) in SSc patients with Pattern A and B than SSc patients with Pattern C and D. The Kaplan-Meier curves showed that free survival from new DUs is lower (p < 0.001) in SSc patients with increased RI (≥0.70) than in SSc patients with normal RI. In multivariate analysis with two co-variates, RI ≥ 0.70 [HR 5.197 (1.471–18.359), p < 0.01] and NVC late scleroderma pattern [HR 7.087 (1.989–25.246), p < 0.01] were predictive markers of new DUs. RI of PPDA in association with NVC could be used to evaluate SSc patients with increased risk of new DUs development. • In systemic sclerosis, microvascular and macrovascular damage is present • Digital ulcers are main vascular complication of systemic sclerosis • Color Doppler Ultrasonography was used to evaluate macrovascular damage of proper palmar digital arteries • In SSc patients with new digital ulcers, morphological and functional damage of proper palmar digital arteries is present • Increased Resistive Index of proper palmar digital arteries is a predictive marker of new digital ulcers [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
11. CD21low B cells in systemic sclerosis: A possible marker of vascular complications.
- Author
-
Marrapodi, Ramona, Pellicano, Chiara, Radicchio, Giovanna, Leodori, Giorgia, Colantuono, Stefania, Iacolare, Andrea, Gigante, Antonietta, Visentini, Marcella, and Rosato, Edoardo
- Subjects
- *
B cells , *SYSTEMIC scleroderma , *VASCULAR endothelial growth factors , *DOPPLER ultrasonography , *PULMONARY function tests - Abstract
To evaluate expansion of CD21low B cells and their role in B cell homeostasis, apoptosis, clinical manifestations and serum vascular endothelial growth factor (VEGF) in systemic sclerosis (SSc). B-cells subpopulations and apoptosis have been assessed in 74 SSc patients and 20 healthy donors. Renal Doppler ultrasound, echocardiography, pulmonary function test and VEGF were performed. SSc patients with expanded CD21low B cells (SSc-CD21low) show a distinct B cell profile with increased memory B cells compared to patients without CD21low B cells (SSc-CD21+). Renal resistive index, systolic pulmonary arterial pressure and FVC/DLCO ratio were significantly higher in SSc-CD21low group than SSc-CD21+, DLCO was lower in SSc-CD21low group than SSc-CD21+. We found a positive linear correlation between CD21low and sPAP, RI and FVC/DLCO ratio whereas a negative correlation was observed between CD21low and DLCO and VEGF levels. CD21low B cells are increased in SSc patients with visceral vascular manifestations. • CD21low percentage of B cells are higher in SSc patients than healthy donor. • CD21low percentage is higher in SSc patients with visceral vascular damage. • VEGF increases in SSc patients with low CD21low percentage. • CD21low percentage is a marker of impaired angiogenesis and vascular damage. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.