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Your search keyword '"Caminal-Montero, L."' showing total 3 results
Start Over Author "Caminal-Montero, L." Topic systemic lupus erythematosus
3 results on '"Caminal-Montero, L."'

1. Predictive Factors of the Use of Rituximab and Belimumab in Spanish Lupus Patients.

Author

Capdevila, O., Mitjavila, F., Espinosa, G., Caminal-Montero, L., Marín-Ballvè, A., González León, R., Castro, A., Canora, J., Pinilla, B., Fonseca, E., and Ruiz-Irastorza, G.

Subjects
BELIMUMAB, RITUXIMAB, LUPUS nephritis, HEMOLYTIC anemia, SYSTEMIC lupus erythematosus, BIOTHERAPY
Abstract

Objectives: To analyze the characteristics and the predictive factors of the use of rituximab and belimumab in daily practice in patients from the inception cohort Registro Español de Lupus (RELES). Material and methods: The study included 518 patients. We considered patients treated with biologics who received at least one dose of rituximab or belimumab, and possible indications of those manifestations registered at the same time or in the previous 2 months of the start of the therapy. Results: In our cohort, 37 (7%) patients received at least one biological treatment. Rituximab was prescribed in 26 patients and belimumab in 11. Rituximab was mainly prescribed for hemolytic anemia or thrombocytopenia (11 patients, 42%), lupus nephritis and neuropsychiatric lupus (5 patients each, 19%). Belimumab was mostly used for arthritis (8 patients, 73%). In the univariate analysis, the predictive factors at diagnosis for the use of biologic therapy were younger age (p = 0.022), a higher SLEDAI (p = 0.001) and the presence of psychosis (p = 0.011), organic mental syndrome (SOCA) (p = 0.006), hemolytic anemia (p = 0.001), or thrombocytopenia (p = 0.01). In the multivariant model, only younger age, psychosis, and hemolytic anemia were independent predictors of the use of biologics. Conclusions: Rituximab is usually given to patients with hematological, neuropsychiatric and renal involvement and belimumab for arthritis. Psychosis, hemolytic anemia and age at the diagnosis of lupus were independent predictive factors of the use of biological agents. Their global effects are beneficial, with a significant reduction in SLE activity and a low rate of side effects. [ABSTRACT FROM AUTHOR]

Published
2023
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2. Impact of Commercial Strain Use on Saccharomyces cerevisiae Population Structure and Dynamics in Pinot Noir Vineyards and Spontaneous Fermentations of a Canadian Winery

Author

Rydén Aulin, M, Boumpas, D, Bultink, I, Callejas, Rubio JL, Caminal Montero, L, Castro, A, Colodro Ruiz, A, Doria, A, Dörner, T, Gonzalez Echavarri, C, Gremese, Elisa, Houssiau, Fa, Huizinga, T, Inanç, M, Isenberg, D, Iuliano, A, Jacobsen, S, Jimenéz Alonso, J, Kovács, L, Mariette, X, Mosca, M, Nived, O, Oristrell, J, Ramos Casals, M, Rascón, J, Ruiz Irastorza, G, Sáez Comet, L, Salvador Cervelló, G, Sebastiani, Gd, Squatrito, D, Szücs, G, Voskuyl, A, and Van Vollenhoven, R.

Subjects
Metabolic Processes, 0301 basic medicine, Settore MED/16 - REUMATOLOGIA, Heredity, lcsh:Medicine, Wine, Yeast and Fungal Models, Biochemistry, Systemic Lupus erythematosus, Medicine and Health Sciences, Vitis, lcsh:Science, education.field_of_study, Heterozygosity, Multidisciplinary, biology, Alcoholic Beverages, food and beverages, Agriculture, Plants, Winery, Horticulture, Rituximab, Research Article, Canada, Farms, Grapes, Genotype, 030106 microbiology, Population, Saccharomyces cerevisiae, Crops, Research and Analysis Methods, Vineyard, Fruits, Beverages, Saccharomyces, 03 medical and health sciences, Model Organisms, Botany, Genetics, Humans, Food microbiology, education, Nutrition, Evolutionary Biology, Population Biology, lcsh:R, Organisms, Fungi, Biology and Life Sciences, 15. Life on land, biology.organism_classification, Yeast, Diet, Metabolism, 030104 developmental biology, Genetic Loci, Fermentation, Food Microbiology, lcsh:Q, Population Genetics, Microsatellite Repeats, Crop Science
Abstract

Wine is produced by one of two methods: inoculated fermentation, where a commercially-produced, single Saccharomyces cerevisiae (S. cerevisiae) yeast strain is used; or the traditional spontaneous fermentation, where yeast present on grape and winery surfaces carry out the fermentative process. Spontaneous fermentations are characterized by a diverse succession of yeast, ending with one or multiple strains of S. cerevisiae dominating the fermentation. In wineries using both fermentation methods, commercial strains may dominate spontaneous fermentations. We elucidate the impact of the winery environment and commercial strain use on S. cerevisiae population structure in spontaneous fermentations over two vintages by comparing S. cerevisiae populations in aseptically fermented grapes from a Canadian Pinot Noir vineyard to S. cerevisiae populations in winery-conducted fermentations of grapes from the same vineyard. We also characterize the vineyard-associated S. cerevisiae populations in two other geographically separate Pinot Noir vineyards farmed by the same winery. Winery fermentations were not dominated by commercial strains, but by a diverse number of strains with genotypes similar to commercial strains, suggesting that a population of S. cerevisiae derived from commercial strains is resident in the winery. Commercial and commercial-related yeast were also identified in the three vineyards examined, although at a lower frequency. There is low genetic differentiation and S. cerevisiae population structure between vineyards and between the vineyard and winery that persisted over both vintages, indicating commercial yeast are a driver of S. cerevisiae population structure. We also have evidence of distinct and persistent populations of winery and vineyard-associated S. cerevisiae populations unrelated to commercial strains. This study is the first to characterize S. cerevisiae populations in Canadian vineyards.

Published
2016

3. Anti-ribosomal P antibodies are associated with elevated circulating IFNα and IL-10 levels in systemic lupus erythematosus patients.

Author

Mozo, L, López, P, Caminal-Montero, L, Rodríguez-Carrio, J, and Suárez, A

Subjects
IMMUNOGLOBULINS, INTERFERON alpha, SYSTEMIC lupus erythematosus, RIBOSOMAL proteins, INTERFERONS, PATIENTS
Abstract

This article presents a study on the link between anti-protein ribosomal P (anti-RibP) antibodies and circulating levels of interferon alpha and IL-10 levels in patients with systemic lupus erythematosus (SLE). It discusses the methods used in the study, characteristics of SLE, and increase in interferon alpha and IL-10 levels in SLE patients with anti-RibP antibodies.

Published
2014
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