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The modern world actively discusses the challenges that will lead to the Fourth Industrial Revolution. As the specialists assume, part of the jobs will be replaced by artificial intelligence. In addition, creation of completely new jobs is expected. As for the jobs that might be maintained in future, skills upgrading will be particularly important. In such a turbulent environment of economic development, universities, and in particular entrepreneurial universities, play a significant role. We think so as these universities have special structures that promote form a university-industry-government triple helix, reskilling and commercialization of new ideas, etc. Due to the above-mentioned factors, they will neutralize the expected fluctuations in the best way. Later we will discuss the systemic links between the mutual influence of entrepreneurial universities and economy. We consider that continuous connection with such universities will enable business to adapt to the inevitable changes with minimal loss. [ABSTRACT FROM AUTHOR]