Gantenbein, Andreas R, Agosti, Reto, Kamm, Christian Philipp, Landmann, Gunther, Meier, Niklaus, Merki-Feld, Gabriele Susanne, Petersen, Jens A, Pohl, Heiko, Ryvlin, Philippe, Schankin, Christoph J, Viceic, Dragana, Zecca, Chiara, Schäfer, Elisabeth, Meyer, Ina, Arzt, Michael E, University of Zurich, and Gantenbein, Andreas R
Background The fully human monoclonal antibody erenumab, which targets the calcitonin gene-related peptide (CGRP) receptor, was licensed in Switzerland in July 2018 for the prophylactic treatment of migraine. To complement findings from the pivotal program, this observational study was designed to collect and evaluate clinical data on the impact of erenumab on several endpoints, such as quality of life, migraine-related impairment and treatment satisfaction in a real-world setting. Methods An interim analysis was conducted after all patients completed 6 months of erenumab treatment. Patients kept a headache diary and completed questionnaires at follow up visits. The overall study duration comprises 24 months. Results In total, 172 adults with chronic or episodic migraine from 19 different sites across Switzerland were enrolled to receive erenumab every 4 weeks. At baseline, patients had 16.6 ± 7.2 monthly migraine days (MMD) and 11.6 ± 7.0 acute migraine-specific medication days per month. After 6 months, erenumab treatment reduced Headache Impact Test (HIT-6™) scores by 7.7 ± 8.4 (p p p p p Conclusions Overall quality of life improved and treatment satisfaction was rated high with erenumab treatment in real-world clinical practice. In addition, the reported impact of migraine on spouses and children of patients was reduced. Trial registration BASEC ID 2018–02,375 in the Register of All Projects in Switzerland (RAPS). Graphical Abstract