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This article discusses the use of phage therapy as an alternative or adjunct to antibiotics in the treatment of bacterial infections in heart and lung transplant patients. The authors describe five cases in which phage therapy was successfully used to treat multidrug-resistant infections in transplant patients. The therapy was personalized based on the specific bacteria involved, and in all cases, the pathogen was completely eradicated after phage therapy. The authors conclude that personalized phage therapy can be recommended for critical conditions in transplantation medicine when conventional antibacterial therapy is inadequate. [Extracted from the article]

This article discusses the development of methods to predict the effectiveness of bacteriophage therapy for surgical site infections after cardiovascular surgery. Surgical site infections are a concern, especially when they involve multidrug-resistant pathogens. Phages, which are viruses that can target and kill bacteria, are being explored as an alternative or supplement to antibiotics. The study describes the development of gelatin-based scaffolds to simulate the conditions in treated tissues and evaluate the protective effect and adhesion rate of bacteriophages. These methods can help optimize phage therapy regimens and establish evidence-based guidelines for their use in cardiovascular surgery. [Extracted from the article]