22 results on '"Jalai, Cyrus M."'
Search Results
2. Prior bariatric surgery lowers complication rates following spine surgery in obese patients.
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Passias, Peter G., Horn, Samantha R., Vasquez-Montes, Dennis, Shepard, Nicholas, Segreto, Frank A., Bortz, Cole A., Poorman, Gregory W., Jalai, Cyrus M., Wang, Charles, Stekas, Nicholas, Frangella, Nicholas J., Deflorimonte, Chloe, Diebo, Bassel G., Raad, Micheal, Vira, Shaleen, Horowitz, Jason A., Sciubba, Daniel M., Hassanzadeh, Hamid, Lafage, Renaud, and Afthinos, John
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SURGICAL complications ,BARIATRIC surgery ,SPINAL surgery ,PROPENSITY score matching ,CERVICAL vertebrae ,HISTORY of surgery - Abstract
Background: Bariatric surgery (BS) is an increasingly common treatment for morbid obesity that has the potential to effect bone and mineral metabolism. The effect of prior BS on spine surgery outcomes has not been well established. The aim of this study was to assess differences in complication rates following spinal surgery for patients with and without a history of BS.Methods: Retrospective analysis of the prospectively collected New York State Inpatient Database (NYSID) years 2004-2013. BS patients and morbidly obese patients (non-BS) were divided into cervical and thoracolumbar surgical groups and propensity score matched for age, gender, and invasiveness and complications compared.Results: One thousand nine hundred thirty-nine spine surgery patients with a history of BS were compared to 1625 non-BS spine surgery patients. The average time from bariatric surgery to spine surgery is 2.95 years. After propensity score matching, 740 BS patients were compared to 740 non-BS patients undergoing thoracolumbar surgery, with similar comorbidity rates. The overall complication rate for BS thoracolumbar patients was lower than non-BS (45.8% vs 58.1%, P < 0.001), with lower rates of device-related (6.1% vs 23.2%, P < 0.001), DVT (1.2% vs 2.7%, P = 0.039), and hematomas (1.5% vs 4.5%, P < 0.001). Neurologic complications were similar between BS patients and non-BS patients (2.3% vs 2.7%, P = 0.62). For patients undergoing cervical spine surgery, BS patients experienced lower rates of bowel issues, device-related, and overall complication than non-BS patients (P < 0.05).Conclusions: Bariatric surgery patients undergoing spine surgery experience lower overall complication rates than morbidly obese patients. This study warrants further investigation into these populations to mitigate risks associated with spine surgery for bariatric patients. [ABSTRACT FROM AUTHOR]
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- 2018
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3. Bone morphogenetic protein in adult spinal deformity surgery: a meta-analysis.
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Poorman, Gregory, Jalai, Cyrus, Boniello, Anthony, Worley, Nancy, McClelland, Shearwood, Passias, Peter, Poorman, Gregory W, Jalai, Cyrus M, McClelland, Shearwood 3rd, and Passias, Peter G
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BONE morphogenetic proteins ,SPINAL surgery ,SPINE abnormalities ,SPONDYLOLISTHESIS ,STENOSIS ,THERAPEUTICS ,GROWTH factors ,RECOMBINANT proteins ,PREVENTION of surgical complications ,SPINAL curvatures ,COMBINED modality therapy ,COMPARATIVE studies ,RESEARCH methodology ,MEDICAL cooperation ,META-analysis ,ORTHOPEDIC surgery ,RESEARCH ,SURGICAL complications ,EVALUATION research ,TREATMENT effectiveness - Abstract
Introduction: Since its introduction BMP has been utilized in populations with higher rates of malunion, such as adult spinal deformity (ASD) patients. Contradictory conclusions exist in spinal literature regarding the safety and efficacy of the use of BMP in this setting. Previous studies, however, did not distinguish deformity cases from spondylolisthesis or stenosis. The purpose of this study is to evaluate the safety and efficacy of BMP use in spinal fusion surgery for ASD.Methods: 166 papers were screened after database search. 40 full texts were assessed for eligibility. Five studies were included for meta-analysis. Three were comparative studies between a BMP and non-BMP group, and the other was used to supplement dose-effect analysis.Results: The current meta-analysis found increased odds of developing radiculitis or neurological complications (OR = 2.18, 95% CI, p = 0.02, i 2 = 0), but no other significant relationship between complications commonly attributed to BMP use (tumorigenesis, infections, seroma formation, or osteolysis) and BMP use. BMP patients had decreased rates of pseudarthrosis (OR = 0.23, 95% CI, p = 0.002, i 2 = 0). There was an average dose of 8.75 mg/level in the 417 patients studied, lower than the advised dosage of 12 mg/level.Conclusions: The current literature shows BMP to be a safe and effective grafting technique in the treatment of ASD. Spine surgeons may currently be using sub-optimal doses of BMP. The benefit of increasing the rate of fusion must be weighed against the increased risk of radiculitis and neurologic complications in this patient population. [ABSTRACT FROM AUTHOR]- Published
- 2017
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4. Predictors of inpatient morbidity and mortality in adult spinal deformity surgery.
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Worley, Nancy, Marascalchi, Bryan, Jalai, Cyrus, Yang, Sun, Diebo, Bassel, Vira, Shaleen, Boniello, Anthony, Lafage, Virginie, Passias, Peter, Jalai, Cyrus M, and Passias, Peter G
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SPINE abnormalities ,INPATIENT care ,SCOLIOSIS ,DISEASE complications ,MULTIVARIATE analysis ,PULMONARY circulation ,PULMONARY circulation disorders ,DIAGNOSIS ,AGE distribution ,DATABASES ,HOSPITAL care ,SEX distribution ,SPINAL fusion ,SURGICAL complications ,COMORBIDITY ,HOSPITAL mortality - Abstract
Purpose: This nationwide study identifies ASD surgical risk factors for morbidity/mortality.Methods: NIS discharges from 2001 to 2010 aged 25+ with scoliosis diagnoses, 4+ levels fused, and procedural codes for anterior and/or posterior thoracic and/or lumbar spinal fusion and refusion were included. Demographics, comorbidities and procedure-related complications were determined for each subgroup (degenerative, congenital, idiopathic, other). Multivariate analysis reported as [OR (95% CI)].Results: 11,982 discharges were identified. Morbidity, excluding device-related, and mortality rates were 50.81 and 0.28%, respectively. Certain comorbidities were associated with increased morbidity/mortality: congestive heart failure (CHF) [1.62 (1.42-1.84)] [5.67 (3.30-9.73)], coagulopathy [3.52 (3.22-3.85)] [2.32 (1.44-3.76)], electrolyte imbalance [2.65 (2.52-2.79)] [4.63 (3.15-6.81)], pulmonary circulation disorders [9.45 (7.45-11.99)] [8.94 (4.43-18.03)], renal failure [1.29 (1.13-1.47)] [5.51 (2.57-11.82)], and pathologic weight loss [2.38 (2.01-2.81)] [7.28 (4.36-12.14)]. Chronic pulmonary disease was associated with higher morbidity [1.08 (1.02-1.14)]; liver disease was linked to increased mortality [36.09 (16.16-80.59)]. 9+ level fusions had increased morbidity vs 4-8 level fusions [1.69 (1.61-1.78)] and refusions [1.08 (1.02-1.14)]. Idiopathic scoliosis was associated with decreased morbidity vs all other subgroups [0.85 (0.80-0.91)]. Age >65 was associated with increased morbidity and mortality vs 25-64 group [1.09 (1.05-1.14)] [3.49 (2.31-5.29)]. Females had increased morbidity [1.18 (1.13-1.23)] and decreased mortality [0.30 (0.21-0.44)]. Mean comorbidity index (0.55) and age (64.38) for degenerative cohort were higher vs all other subgroups (P < 0.0001).Conclusions: Longer fusions were associated with increased morbidity. Age >65 was associated with increased morbidity/mortality, while females were associated with increased morbidity but decreased mortality. Idiopathic scoliosis had decreased morbidity. Degenerative ASD cases had higher comorbidity indices, potentially due to older age. This study is clinically useful for patient education, surgical decision-making, and optimizing patient outcomes. [ABSTRACT FROM AUTHOR]- Published
- 2016
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5. The Impact of Advanced Age on Peri-Operative Outcomes in the Surgical Treatment of Cervical Spondylotic Myelopathy: A Nationwide Study Between 2001 and 2010.
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Jalai, Cyrus M., Worley, Nancy, Marascalchi, Bryan J., Challier, Vincent, Vira, Shaleen, Sun Yang, Boniello, Anthony J., Bendo, John A., Lafage, Virginie, Passias, Peter G., and Yang, Sun
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CERVICAL spondylotic myelopathy , *CERVICAL vertebrae , *LOGISTIC regression analysis , *PATHOLOGICAL physiology , *SPONDYLOSIS , *SURGERY , *THERAPEUTICS , *AGE distribution , *COMPARATIVE studies , *LAMINECTOMY , *LONGITUDINAL method , *RESEARCH methodology , *MEDICAL cooperation , *RESEARCH , *SPINAL cord diseases , *SPINAL fusion , *SURGICAL complications , *EVALUATION research , *TREATMENT effectiveness , *RETROSPECTIVE studies , *PERIOPERATIVE care , *DIAGNOSIS ,MORTALITY risk factors - Abstract
Study Design: Retrospective multicenter database review.Objective: The aim of this study was to evaluate national postoperative outcomes and hospital characteristics trends from 2001 to 2010 for advanced age CSM patients.Summary Of Background Data: Recent studies show increases in US cervical spine surgeries and CSM diagnoses. However, few have compared national outcomes for elderly and younger CSM patients.Methods: A Nationwide Inpatient Sample (NIS) analysis from 2001 to 2010, including CSM patients 25+ who underwent anterior and/or posterior cervical fusion or laminoplasty. Fractures, 9+ levels fused, or any cancers were excluded. Measures included demographics, outcomes, and hospital-related data for 25 to 64 versus 65+ and 65 to 75 versus 76+ age groups. Univariate and logistic regression modeling evaluated procedure-related complications risk in 65+ and 76+ age groups (OR[95% CI]).Results: Discharges for 35,319 patients in the age range of 25 to 64 years and 19,097 at the age 65+ years were identified. Average comorbidity indices for patients at 65+ years were higher compared to the 25 to 64 years age group (0.79 vs. 0.0.44, P < 0.0001), as was the total complications rate (11.39% vs. 5.93%, P < 0.0001) and charges ($57,449.94 vs. $49,951.11, P < 0.0001). Hospital course for aged 65+ patients was longer (4.76 vs. 3.26 days, P < 0.0001). Mortality risk was higher in the 65+ cohort (3.38[2.93-3.91]), adjusted for covariates. 65+ patients had increased risk of all complications except device-related, for which they had decreased risk (0.61[0.56-0.67]). Patients 76+ years displayed increased hospital charges ($59,197.60 vs. $56,601.44, P < 0.001) and courses (5.77 vs. 4.28 days, P < 0.001) compared to those in the age group 65 to 75 years. These same patients presented with increased Deyo scores (0.83 vs. 0.77, P < 0.001), had increased total complications rate (13.87% vs. 10.20%, P < 0.001), and displayed increased risk for postoperative shock (6.34 [11.16-3.60], P < 0.001), digestive system (1.92 [2.40-1.54], P < 0.001), and wound dehiscence (1.71 [2.56-1.15], P < 0.001).Conclusion: Patients aged 65+ years undergoing CSM surgical management have a higher mortality risk, more procedure-related complications, higher comorbidity burden, longer hospital course, and higher charges. This study provides clinically useful data for surgeons to educate patients and to improve outcomes. [ABSTRACT FROM AUTHOR]- Published
- 2016
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6. 138 - Primary Drivers of Cervical Deformity: Prevalence and Effect of Surgical Treatment Strategies on Postoperative Alignment.
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Passias, Peter G., Jalai, Cyrus M., Lafage, Virginie, Lafage, Renaud, Protopsaltis, Themistocles S., Ramachandran, Subbu, Gupta, Munish C., Hart, Robert A., Deviren, Vedat, Soroceanu, Alexandra, Smith, Justin S., Schwab, Frank J., and Shaffrey, Christopher I.
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SPINE abnormalities , *SPINAL surgery , *SURGICAL complications , *DISEASE prevalence , *MEDICAL research , *THERAPEUTICS ,CERVICAL vertebrae abnormalities - Published
- 2016
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7. 204 - Characterizing Cervical Spine Deformity Based on Existing Cervical and Adult Deformity Classification Schemes at Presentation and following Treatment.
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Passias, Peter G., Jalai, Cyrus M., Smith, Justin S., Lafage, Virginie, Diebo, Bassel G., Protopsaltis, Themistocles S., Poorman, Gregory W., Ramchandran, Subaraman, Bess, Shay, Shaffrey, Christopher I., Ames, Christopher P., and Schwab, Frank J.
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SPINE abnormalities , *SPINAL surgery , *SPINE abnormality diagnosis , *SPINE radiography , *SURGICAL complications , *THERAPEUTICS ,CERVICAL vertebrae abnormalities ,DISEASES in adults - Published
- 2016
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8. 86 - Thresholds of Body Mass Index as a Predictor of Morbidity in Lumbar Spinal Surgery Based on Surgical Invasiveness.
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Poorman, Gregory W., Jalai, Cyrus M., Soroceanu, Alexandra, Line, Breton, Bess, Shay, Vira, Shaleen, Diebo, Bassel G., Ramachandran, Subbu, Foster, Norah A., Oren, Jonathan H., Protopsaltis, Themistocles S., Errico, Thomas J., Buckland, Aaron J., Lafage, Virginie, and Passias, Peter G.
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LUMBAR vertebrae surgery , *BODY mass index , *LUMBAR vertebrae diseases , *SURGICAL complications , *LOGISTIC regression analysis , *THERAPEUTICS - Published
- 2016
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9. P137 - Comparative Analysis of Intra-Operative Complications between a Multicenter Prospective Cervical Deformity Database versus a Nationwide Sample.
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Jalai, Cyrus M., Passias, Peter G., Poorman, Gregory W., Smith, Justin S., Scheer, Justin K., Sciubba, Daniel M., Hamilton, D. Kojo, Jr.Mundis, Gregory M., Klineberg, Eric O., Lafage, Virginie, Shaffrey, Christopher I., and Ames, Christopher P.
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CERVICAL vertebrae , *SURGICAL complications , *MEDICAL databases , *SPINE abnormalities , *COMPARATIVE studies , *LONGITUDINAL method , *SURGERY , *THERAPEUTICS - Published
- 2016
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10. Comparative analysis of perioperative complications between a multicenter prospective cervical deformity database and the Nationwide Inpatient Sample database.
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Passias, Peter G., Horn, Samantha R., Jalai, Cyrus M., Poorman, Gregory, Bono, Olivia J., Ramchandran, Subaraman, Smith, Justin S., Scheer, Justin K., Sciubba, Daniel M., Hamilton, D. Kojo, Mundis, Gregory, Oh, Cheongeun, Klineberg, Eric O., Lafage, Virginie, Shaffrey, Christopher I., Ames, Christopher P., and International Spine Study Group
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SPINAL cord diseases , *SPINAL cord surgery , *BONFERRONI correction , *MULTIPLE comparisons (Statistics) , *PATIENTS , *THERAPEUTICS , *CERVICAL vertebrae , *COMPARATIVE studies , *DATABASES , *DEGLUTITION disorders , *HOSPITAL patients , *RESEARCH methodology , *MEDICAL cooperation , *RESEARCH , *SPINAL fusion , *SURGICAL complications , *EVALUATION research , *DISCHARGE planning , *SPINAL curvatures , *SURGERY , *STANDARDS - Abstract
Background Context: Complication rates for adult cervical deformity are poorly characterized given the complexity and heterogeneity of cases.Purpose: To compare perioperative complication rates following adult cervical deformity corrective surgery between a prospective multicenter database for patients with cervical deformity (PCD) and the Nationwide Inpatient Sample (NIS).Study Design/setting: Retrospective review of prospective databases.Patient Sample: A total of 11,501 adult patients with cervical deformity (11,379 patients from the NIS and 122 patients from the PCD database).Outcome Measures: Perioperative medical and surgical complications.Methods: The NIS was queried (2001-2013) for cervical deformity discharges for patients ≥18 years undergoing cervical fusions using International Classification of Disease, Ninth Revision (ICD-9) coding. Patients ≥18 years from the PCD database (2013-2015) were selected. Equivalent complications were identified and rates were compared. Bonferroni correction (p<.004) was used for Pearson chi-square. Binary logistic regression was used to evaluate differences in complication rates between databases.Results: A total of 11,379 patients from the NIS database and 122 patiens from the PCD database were identified. Patients from the PCD database were older (62.49 vs. 55.15, p<.001) but displayed similar gender distribution. Intraoperative complication rate was higher in the PCD (39.3%) group than in the NIS (9.2%, p<.001) database. The PCD database had an increased risk of reporting overall complications than the NIS (odds ratio: 2.81, confidence interval: 1.81-4.38). Only device-related complications were greater in the NIS (7.1% vs. 1.1%, p=.007). Patients from the PCD database displayed higher rates of the following complications: peripheral vascular (0.8% vs. 0.1%, p=.001), gastrointestinal (GI) (2.5% vs. 0.2%, p<.001), infection (8.2% vs. 0.5%, p<.001), dural tear (4.1% vs. 0.6%, p<.001), and dysphagia (9.8% vs. 1.9%, p<.001). Genitourinary, wound, and deep veinthrombosis (DVT) complications were similar between databases (p>.004). Based on surgicalapproach, the PCD reported higher GI and neurologic complication rates for combined anterior-posterior procedures (p<.001). For posterior-only procedures, the NIS had more device-related complications (12.4% vs. 0.1%, p=.003), whereas PCD had more infections (9.3% vs. 0.7%, p<.001).Conclusions: Analysis of the surgeon-maintained cervical database revealed higher overall and individual complication rates and higher data granularity. The nationwide database may underestimate complications of patients with adult cervical deformity (ACD) particularly in regard to perioperative surgical details owing to coding and deformity generalizations. The surgeon-maintained database captures the surgical details, but may underestimate some medical complications. [ABSTRACT FROM AUTHOR]- Published
- 2017
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11. Morbidity of Adult Spinal Deformity Surgery in Elderly Has Declined Over Time.
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Passias, Peter G., Poorman, Gregory W., Jalai, Cyrus M., Neuman, Brian, de la Garza-Ramos, Rafael, Miller, Emily, Jain, Amit, Sciubba, Daniel, McClelland, Shearwood, Day, Loui, Ramchandran, Subaraman, Vira, Shaleen, Diebo, Bassel, Isaacs, Evan, Bono, Olivia, Bess, Shay, Gerling, Michael, Lafage, Virginie, and Day, Louis
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SCOLIOSIS treatment , *SCOLIOSIS , *SCOLIOSIS complications , *SURGICAL complications , *LUMBAR pain , *PROGNOSIS , *BACK , *AGING , *DISEASES , *NEUROSURGERY , *SPINAL fusion , *RETROSPECTIVE studies , *SURGICAL decompression , *SURGERY - Abstract
Study Design: A retrospective review of a prospectively collected database, the Nationwide Inpatient Sample (NIS), years 2003 to 2012.Objectives: The aim of this study was to examine trends in the management of scoliosis in elderly (age >75 yrs) patients from 2003 to 2012.Summary Of Background Data: Scoliosis incidence rises with increasing age, and age has been shown to be an independent risk factor for surgical complications in scoliosis surgery. Previous studies have displayed increasing surgical frequency on elderly scoliotic patients in the last decade, but have not investigated complications in the same years.Methods: ICD-9 coding identified elderly (age ≥75 yrs) patients with a primary diagnosis of scoliosis undergoing lumbar fusion or decompression. Analysis of variance (ANOVA) comparisons and linear trend analysis described changes from 2003 to 2012 in surgical invasiveness (Mirza scale: levels fused/decompressed/instrumented and by approach), intraoperative complications, and Charlson Comorbidity Index (CCI). Secondary outcome measures included cost and discharge outcomes.Results: Eight thousand one elderly patients with ASD from 2003 to 2012 were included for analysis. Fusion incidence increased on average 13.8% per year (P < 0.001), surgical invasiveness by Mirza scale increased from 2.0 in 2003 to 5.9 in 2012 (P < 0.001), and CCI increased from 0.77 to 1.44 (p < 0.001). Over the same interval, elderly patients undergoing fusion displayed overall reduction in complications (excluding anemia)-from 26.7% to 8.6% (P < 0.001); specifically, surgical complications decreased from 11.7% to 0.7% (P < 0.001) and respiratory complications decreased from 6.7% to 1.4% (P = 0.004).Conclusion: From 2003 to 2012, surgical management of ASD in the elderly population increased in incidence and complexity, while number of patient comorbidities increased and in-hospital morbidity decreased. This may indicate increased willingness of surgeon's to operate on elderly patients, and reflect a development of overall understanding of deformity in the past decade.Level Of Evidence: 3. [ABSTRACT FROM AUTHOR]- Published
- 2017
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12. Outcomes of open staged corrective surgery in the setting of adult spinal deformity.
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Passias, Peter G., Poorman, Gregory W., Jalai, Cyrus M., Line, Breton, Diebo, Bassel, Park, Paul, Hart, Robert, Burton, Douglas, Schwab, Frank, Lafage, Virginie, Bess, Shay, Errico, Thomas, and International Spine Study Group
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SPINE abnormalities , *SPINAL fusion , *SURGICAL complications , *RETROSPECTIVE studies , *SPINAL surgery , *COMPARATIVE studies , *HEALTH surveys , *RESEARCH methodology , *MEDICAL cooperation , *QUALITY of life , *QUESTIONNAIRES , *REOPERATION , *RESEARCH , *SCOLIOSIS , *EVALUATION research ,DISEASES in adults - Abstract
Background Context: Adult spinal deformity (ASD) represents a constellation of complex malalignments affecting the spinal column. Corrective surgical procedures aimed at improving ASD can be equally challenging, and commonly require multiple index procedures and potential revisions before definitive management. There is a paucity of data comparing the outcomes of same-day(simultaneous [SIM]) and 2-day (staged [STA]) procedures for long spinal fusions for ASD. Using a large patient cohort with surgeon- and patient-reported outcomes will be particularly useful in determining the utility and effect of staging long spinal fusions for ASD.Purpose: This study aimed to compare intraoperative, perioperative, and 2-year outcomes of STA and SIM procedures correcting ASD.Study Design: This is a retrospective analysis of a prospective multicenter database.Patient Sample: A total of 142 patients (71 STA, 71 SIM) were included.Outcome Measures: Primary outcome measures were intra- and perioperative (6 weeks) complication rates. Secondary outcome measures were 2-year thoracolumbar and spinopelvic radiographic parameters, 2-year health-related quality of life (HRQoL) changes (Oswestry Disability Index [ODI] and Short Form-36 [SF-36]), and 2-year complication rates.Methods: Inclusion criteria included patients with ASD ≥18 years with 6-week and 2-year follow-up. Propensity score matching identified similar patients undergoing STA or SIM long spinal fusions based on surgical invasiveness, pelvic tilt, and sagittal vertical axis (SVA). Complications, HRQoL scores (Scoliosis Research Society-22 Patient Questionnaire [SRS-22r], SF-36, ODI), and patient characteristics were compared across and within treatment groups at follow-up with analysis of variance (ANOVA) and paired t tests at three surgical stages: intraoperatively, perioperatively (6 weeks), and postoperatively (>6 weeks).Results: A total of 142 patients were included (71 STA, 71 SIM). Matching STA and SIM groups based on degree of deformity and surgical invasiveness created two groups similar in overall correction of the surgery. Patients undergoing STA underwent more anterior lumbar interbody fusion (ALIF) and lateral lumbar interbody fusion (LLIF) procedures, whereas patients undergoing SIM had longer fusions. Charlson comorbidity index and revision status were similar between groups (p>.05). Staging procedures had significantly more complications causing reoperation (STA: 47% vs. SIM: 8%, p=.021), and had a greater number of perioperative complications requiring a return to the operating room (OR) (STA: 9.9% vs. SIM: 1.4%, p=.029). There was no difference in intraoperative complications, mortality, or perioperative infection or wound complications (p>.05) between the two procedures. At 2-year follow-up, incidence of revision surgery was higher in STA (STA: 21.1% vs. SIM: 8.5%, p=.033).Conclusion: Staged spinal fusions, which add ALIFs and LLIFs to the procedure, compared with similar-correction SIM procedures, result in similar intraoperative complication incidence, but significantly higher rates of peri- and postoperative complications leading to revision. Functional outcomes, radiographic parameters, and mortality were similar. This will aid surgeons in their determination of the optimal treatment for such complex procedures. [ABSTRACT FROM AUTHOR]- Published
- 2017
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13. Hospital Readmission Within 2 Years Following Adult Thoracolumbar Spinal Deformity Surgery: Prevalence, Predictors, and Effect on Patient-derived Outcome Measures.
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Passias, Peter G., Klineberg, Eric O., Jalai, Cyrus M., Worley, Nancy, Poorman, Gregory W., Line, Breton, Cheongeun Oh, Burton, Douglas C., Han Jo Kim, Sciubba, Daniel M., Hamilton, D. Kojo, Ames, Christopher P., Smith, Justin S., Shaffrey, Christopher I., Lafage, Virginie, Bess, Shay, Oh, Cheongeun, Kim, Han Jo, and International Spine Study Group
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PATIENT readmissions , *REOPERATION , *KYPHOSIS , *PSEUDARTHROSIS , *TREATMENT effectiveness , *SPINAL surgery , *LONGITUDINAL method , *QUALITY of life , *SCOLIOSIS , *SURGICAL complications , *DISEASE prevalence , *RETROSPECTIVE studies , *LORDOSIS - Abstract
Study Design: A retrospective review of prospective multicenter database.Objective: The aim of this study was to identify factors influencing readmission, reoperation, and the impact on health-related quality of life outcomes (HRQoLs) in adult spinal deformity (ASD) surgery.Summary Of Background Data: Many ASD patients experience complications requiring readmission. It is important to identify baseline/operative factors leading to rehospitalizations and reoperation, which may impact outcomes.Methods: Inclusion Criteria: ASD surgical patients (age >18 yrs, major coronal Cobb ≥20°, sagittal vertical axis ≥5 cm, pelvic tilt ≥25°, and/or thoracic kyphosis >60°) with complete baseline, 1-, and 2-year follow-up. Patients were grouped on the basis of readmission occurrence (yes/no) and type [medical (no reoperation) vs. surgical (revision surgery)]. Readmissions caused by infections requiring surgical treatment (e.g., deep infections) were considered reoperations. Univariate and multivariate analyses determined readmission and reoperation predictors. Repeated measures mixed models evaluated readmission impact on HRQoLs at 1 and 2 years.Results: Three hundred thirty-four patients were included: 76 (22.8%) readmissions, involving 65 (85.5% of 76) reoperations (surgical readmission) and 11 (14.5% of 76) medical readmissions. The most common surgical readmission indication (n = 65) was implant complications (36.9%; rod breakage n = 13); the most common medical readmission indication was infection (36.4%, n = 4), treated with antibiotics. Noninfectious medical readmission (n = 7) included pleural effusion, deep vein thrombosis (DVT), intraoperative blood loss, neurologic, and unspecified. Readmission predictors: increased number of major peri-operative complications [odds ratio (OR) 5.13, P = 0.014], infection presence (OR 25.02, P = 0.001), implant complications (OR 6.12, P < 0.001), and radiographic complications (DJK, proximal junctional kyphosis, pseudoarthrosis, sagittal/coronal imbalance) (OR 16.94, P < 0.001). HRQoL analysis revealed overall improvement of the full cohort (P < 0.01), though the 76 readmitted improved less overall and at each time point P < 0.001) except in 6-week MCS (P = 0.14).Conclusion: Major peri-operative, implant, radiographic, and infection complications during index were associated with increased readmission odds. Implant complications most frequently caused surgical readmissions. Readmitted patients improved in outcome scores, although less compared with the nonreadmitted cohort, yet displayed reduced 6-week SF-36 Mental Component Summary.Level Of Evidence: 3. [ABSTRACT FROM AUTHOR]- Published
- 2016
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14. Effect of Obesity on Radiographic Alignment and Short-Term Complications After Surgical Treatment of Adult Cervical Deformity.
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Passias, Peter G., Poorman, Gregory W., Horn, Samantha R., Jalai, Cyrus M., Bortz, Cole, Segreto, Frank, Diebo, Bassel M., Daniels, Alan, Hamilton, D. Kojo, Sciubba, Daniel, Smith, Justin, Neuman, Brian, Shaffrey, Christopher I., LaFage, Virginie, LaFage, Renaud, Schwab, Frank, Bess, Shay, Ames, Christopher, Hart, Robert, and Soroceanu, Alexandra
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LORDOSIS , *OBESITY , *THERAPEUTICS , *SURGICAL complications , *BODY mass index , *HUMAN abnormalities , *LOGISTIC regression analysis - Abstract
We investigated the 30-day complication incidence and 1-year radiographic correction in obese patients undergoing surgical treatment of cervical deformity. The patients were stratified according to World Health Organization's definition for obesity: obese, patients with a body mass index of ≥30 kg/m2; and nonobese, patients with a body mass index of <30 kg/m2. The patients had undergone surgery for the treatment of cervical deformity. The patient baseline demographic, comorbidity, and radiographic data were compared between the 2 groups at baseline and 1 year postoperatively. The 30-day complication incidence was stratified according to complication severity (any, major, or minor), and type (cardiopulmonary, dysphagia, infection, neurological, and operative). Binary logistic regression models were used to assess the effect of obesity on developing those complications, with adjustment for patient age and levels fused. A total of 124 patients were included, 53 obese and 71 nonobese patients. The 2 groups had a similar T1 slope minus cervical lordosis (obese, 37.2° vs. nonobese, 36.9°; P = 0.932) and a similar C2–C7 (−5.9° vs. −7.3°; P = 0.718) and C2–C7 (50.1 mm vs. 44.1 mm; P = 0.184) sagittal vertical axis. At the 1-year follow-up examination, the T1 pelvic angle (1.0° vs. −3.1°; P = 0.021) and C2–S1 sagittal vertical axis (−5.9 mm vs. −35.0 mm; P = 0.036) were different, and the T1 spinopelvic inclination (−1.0° vs. −2.9°; P = 0.123) was similar. The obese patients had a greater risk of overall short-term complications (odds ratio, 2.5; 95% confidence interval, 1.1–6.1) and infectious complications (odds ratio, 5.0; 95% confidence interval, 1.0–25.6). Obese patients had a 5 times greater odds of developing infections after surgery for adult cervical deformity. Obese patients also showed significantly greater pelvic anteversion after cervical correction. [ABSTRACT FROM AUTHOR]
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- 2019
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15. Predictors of adverse discharge disposition in adult spinal deformity and associated costs.
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Passias, Peter G., Poorman, Gregory W., Bortz, Cole A., Qureshi, Rabia, Diebo, Bassel G., Paul, Justin C., Horn, Samantha R., Segreto, Frank A., Pyne, Alexandra, Jalai, Cyrus M., Lafage, Virginie, Bess, Shay, Schwab, Frank J., and Hassanzadeh, Hamid
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SPINAL injuries , *SPINE abnormalities , *BACK injuries , *OSTEOTOMY , *ORTHOPEDIC surgery , *SPINAL surgery , *MEDICAL care cost statistics , *DATABASES , *MEDICARE , *QUALITY assurance , *SCOLIOSIS , *SURGICAL complications , *ACTIVITIES of daily living , *DISCHARGE planning , *RETROSPECTIVE studies , *FERRANS & Powers Quality of Life Index , *IMPACT of Event Scale - Abstract
Background Context: With advances in the understanding of adult spinal deformity (ASD), more complex osteotomy and fusion techniques are being implemented with increasing frequency. Patients undergoing ASD corrections infrequently require extended acute care, longer inpatient stays, and are discharged to supervised care. Given the necessity of value-based health care, identification of clinical indicators of adverse discharge disposition in ASD surgeries is paramount.Purpose: Using the nationwide and surgeon-created databases, the present study aimed to identify predictors of adverse discharge disposition after ASD surgeries and view the corresponding differences in charges.Study Design/setting: This is a retrospective analysis of patients on the National Surgical Quality Improvement Program (NSQIP) database and of cost data from Medicare PearlDiver Database.Patient Sample: Patients undergoing thoracolumbar surgery for correction of ASD were included in the study.Outcome Measures: Primary analysis was performed to compare patients discharged to home with patients who either expired or were discharged to locations other than home. Secondary analysis was performed to determine the cost differences across discharge groups.Methods: Patients on NSQIP undergoing thoracolumbar ASD-corrective surgery with a primary diagnosis of scoliosis (ICD-9 code 737.x) and over the age of 18 were isolated. Predictors (demographic, clinical, and complications) of not-home (NH; rehab or skilled nursing facility) discharge were analyzed using binary logistic regression controlling for levels fused, decompressions, osteotomies, and revisions. Average 30- and 90-day costs of care were reported in home, rehab, and skilled nursing facility discharge groups in patients undergoing 8+ level thoracolumbar fusion.Results: A total of 1,978 patients undergoing lumbar ASD-corrective surgery were included for analysis (average age: 59.3 years, sex: 64% female). Average length of stay was 6.58 days. On multivariate regression analysis, age over 60 years (odds ratio [OR]: 0.28, confidence interval [CI]: 0.22-0.34) and female sex (p=.003) were independent predictors of adverse discharge status. Partially dependent preoperational functional status, defined as reliance on another person to complete some activities of daily living, increased likelihood of adverse discharge disposition (OR: 0.57, CI: 0.35-0.90). Despite controlling for all clinical variables except for the ones specific to each analysis, Smith-Petersen osteotomy (OR: 0.51, CI: 0.40-0.64), interbody device placement (OR: 0.80, CI: 0.64-0.98), and fixation to the iliac (OR: 0.54, CI: 0.41-0.70) increased the likelihood of adverse discharge. Complications most associated with adverse discharge were urinary tract infections (OR: 0.34, CI: 0.21-0.57) and blood transfusions (OR: 0.42, CI: 0.34-0.52). Relative to home discharge, 30-day costs of care were +$21,061 more expensive in rehab discharges, but not different in skilled nursing facility discharges (+$5,791, p=.177). The 90-day costs of care were $23,815 in rehab discharges (p<.001), but again not different from skilled nursing facility discharges (+$6,091, p=.212).Conclusions: Discharge destination to rehabilitation has a significant impact on the cost of thoracolumbar ASD surgeries. Patient selection can predict patients at higher risk of discharges to rehab or skilled nursing facility. [ABSTRACT FROM AUTHOR]- Published
- 2018
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16. Body mass index predicts risk of complications in lumbar spine surgery based on surgical invasiveness.
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Bono, Olivia J., Poorman, Gregory W., Foster, Norah, Jalai, Cyrus M., Horn, Samantha R., Oren, Jonathan, Soroceanu, Alexandra, Ramachandran, Subaraman, Purvis, Taylor E., Jain, Deeptee, Vira, Shaleen, Diebo, Bassel G., Line, Breton, Sciubba, Daniel M., Protopsaltis, Themistocles S., Buckland, Aaron J., Errico, Thomas J., Lafage, Virginie, Bess, Shay, and Passias, Peter G.
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BODY mass index , *LUMBAR vertebrae surgery , *SPINE diseases , *OBESITY , *COMORBIDITY , *THERAPEUTICS , *OBESITY complications , *LEANNESS , *ORTHOPEDIC surgery , *QUALITY assurance , *RISK assessment , *SURGICAL complications , *RETROSPECTIVE studies ,SURGICAL complication risk factors - Abstract
Background Context: Obesity as a comorbidity in spine pathology may increase the risk of complications following surgical treatment. The body mass index (BMI) threshold at which obesity becomes clinically relevant, and the exact nature of that effect, remains poorly understood.Purpose: Identify the BMI that independently predicts risk of postoperative complications following lumbar spine surgery.Study Design/setting: Retrospective review of the National Surgery Quality Improvement Program (NSQIP) years 2011-2013.Patient Sample: A total of 31,763 patients were undergoing arthrodesis, discectomy, laminectomy, laminoplasty, corpectomy, or osteotomy of the lumbar spine.Outcome Measures: Complication rates.Methods: The patient sample was categorized preoperatively by BMI according to the World Health Organization stratification: underweight (BMI <18.5), normal overweight (BMI 20.0-29.9), obesity class 1 (BMI 30.0-34.9), 2 (BMI 35.0-39.9), and 3 (BMI≥40). Patients were dichotomized based on their position above or below the 75th surgical invasiveness index (SII) percentile cutoff into low-SII and high-SII. Differences in complication rates in BMI groups were analyzed by Bonferroni analysis of variance (ANOVA) method. Multivariate binary logistic regression evaluated relationship between BMI and complication categories in all patients and in high-SII and low-SII surgeries.Results: Controlling for baseline difference in SII, Charlson Comorbidity Index (CCI) score, diabetes, hypertension, and smoking, complications significantly increased at a BMI of 35 kg/m2. The odds ratios for any complication (odds ratio [OR] [95% confidence interval {CI}]; obesity 2: 1.218 [1.020-1.455]; obesity 3: 1.742 [1.439-2.110]), infection (obesity 2: 1.335 [1.110-1.605]; obesity 3: 1.685 [1.372-2.069]), and surgical complication (obesity 2: 1.622 [1.250-2.104]; obesity 3: 2.798 [2.154-3.634]) were significantly higher in obesity classes 2 and 3 relative to the normal-overweight cohort (all p<.05).Conclusion: There is a significant increase in complications, specifically infection and surgical complications, in patients with BMI≥35 following lumbar spine surgery, with that rate further increasing with BMI≥40. [ABSTRACT FROM AUTHOR]- Published
- 2018
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17. Comparative Analysis of Perioperative Outcomes Using Nationally Derived Hospital Discharge Data Relative to a Prospective Multicenter Surgical Database of Adult Spinal Deformity Surgery.
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Poorman, Gregory W., Passias, Peter G., Buckland, Aaron J., Jalai, Cyrus M., Kelly, Michael, Sciubba, Daniel M., Neuman, Brian J., Hamilton, D. Kojo, Jain, Amit, Diebo, Bassel, Lafage, Virginie, Bess, Shay, Klineberg, Eric O., and International Spine Study Group (ISSG)
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SPINE diseases , *SPINAL surgery , *DISEASE complications , *SURGICAL complications , *COMORBIDITY , *COMPARATIVE studies , *DATABASES , *LONGITUDINAL method , *RESEARCH methodology , *MEDICAL cooperation , *RESEARCH , *EVALUATION research , *PATIENT discharge instructions , *TREATMENT effectiveness , *PERIOPERATIVE care , *DIAGNOSIS ,SPINE diseases diagnosis - Abstract
Study Design: Retrospective analysis of three prospectively collected databases.Objective: To compare perioperative outcomes in Adult Spinal Deformity (ASD) surgeries in a surgeon-run (SR-ASD) and two national databases: the Nationwide Inpatient Sample (NIS) and the National Surgical Quality Improvement Program (NSQIP).Summary Of Background Data: Much has been learned on the treatment of ASD in the last decade with prospective multicenter collaborative research focusing on this specific condition. Nondisease specific national databases are being used for hypothesis and quality control testing on a large number of ASD patients. Their accuracy and applicability remains unevaluated.Methods: Patients were identified on each respective database undergoing lumbar spine fusion for ASD. Propensity score matching established cohorts of patients on each database with similar procedures being performed. Complication prevalence and relative risk was compared on the NIS and NSQIP against SR-ASD. Secondary outcome measures included hospital-stay characteristics, surgical invasiveness, patient demographics, and patient comorbidities.Results: Two hundred fifty-five patients were identified on each database 1:1:1 with similar overall surgical intensity. Querying the databases using ICD-9 codes, CPT codes, and surgeon-reports resulted in different complication incidences: overall complication rates were 17.65% on NIS, 24.31% on NSQIP, and 68.24% on SR-ASD. The relative risk of a medical complication in SR-ASD was 1.87 (1.42-2.48) relative to NIS and 1.91 (1.44-2.54) relative to NSQIP. The relative risk of a surgical complication was 5.45 (2.69-11.05) compared with NIS and 12.05 (3.98-36.49) compared with NSQIP.Conclusion: After selecting patients using the same criteria and diagnosis, NIS, NSQIP, and SR-ASD databases captured different patient populations and different complication incidences. There were total absences of certain complications contrary to usual literature rates in all three databases. Faithful reporting necessitates understanding database limitations, and careful evaluation of database strengths and weaknesses is paramount to accurate reports.Level Of Evidence: 3. [ABSTRACT FROM AUTHOR]- Published
- 2017
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18. P42 - Congenital versus Idiopathic Scoliosis: Comparison of In-Hospital Comorbidities Using Nationwide Inpatient Database (KID).
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Passias, Peter G., Poorman, Gregory W., Jalai, Cyrus M., Diebo, Bassel G., Vira, Shaleen, Baker, Joseph F., Shenoy, Kartik, Hasan, Saqib, Buza, John, Bronson, Wesley, Paul, Justin C., Kaye, Ian, Atanda, Abiola, Cassilly, Ryan T., Foster, Norah A., Oren, Jonathan H., Lafage, Virginie, and Errico, Thomas J.
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SCOLIOSIS , *SURGICAL complications , *SPINAL fusion , *MEDICAL care costs , *PATIENTS , *DIAGNOSIS - Published
- 2016
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19. 274 - Outcomes of Open Staged Corrective Surgery in the Setting of Adult Spinal Deformity.
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Passias, Peter G., Poorman, Gregory W., Jalai, Cyrus M., Line, Breton, Diebo, Bassel G., Park, Paul, Hart, Robert A., Burton, Douglas C., Schwab, Frank J., Lafage, Virginie, Bess, Shay, and Errico, Thomas J.
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SPINAL fusion , *SURGICAL complications , *SPINE radiography , *QUALITY of life , *DISEASE incidence , *FOLLOW-up studies (Medicine) ,TREATMENT of spine diseases - Published
- 2016
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20. Primary Versus Revision Surgery in the Setting of Adult Spinal Deformity: A Nationwide Study on 10,912 Patients.
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Diebo, Bassel G., Passias, Peter G., Marascalchi, Bryan J., Jalai, Cyrus M., Worley, Nancy J., Errico, Thomas J., and Lafage, Virginie
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REOPERATION , *SPINAL fusion , *SURGICAL complications , *COMORBIDITY , *DISEASE incidence , *RETROSPECTIVE studies , *SPINAL curvatures , *DISEASE complications - Abstract
Study Design: Retrospective review of a prospectively collected database.Objective: This study compares patient demographics, incidence of comorbidities, procedure-related complications, and mortality following primary versus revision adult spinal deformity surgery SUMMARY OF BACKGROUND DATA.: Although adult spinal deformity (ASD) surgery has been extensively investigated, no previous study has provided nationwide estimates of patient characteristics and procedure-related complications for primary versus revision spinal deformity surgery comparatively.Methods: Nationwide Inpatient Sample data collected between 2001 and 2010 was analyzed. Discharges with procedural codes for anterior and/or posterior thoracic and/or lumbar spinal fusion and refusion were included for patients aged 25+ and 4+ levels fused with any diagnoses specific for scoliosis. Patient demographics, comorbidity, and procedure-related complications incidence were determined for primary versus revision cohorts. Multivariate analysis reported as (OR [95% CI]).Results: Discharges for 9133 primary and 850 revision cases were identified. Patients differed on the basis of demographic and hospital data. Average comorbidity indices for the cohorts were similar (P = 0.580), as was in-hospital mortality (P = 0.163). The incidence of procedure-related complications was higher for the revision cohort (46.96 % vs. 71.97%, P = 0.001). The mean hospital course for the revision cohort was longer (6.37 vs. 7.13 days, P < 0.0001). Revisions had an increased risk of complications involving the nervous system (1.34[1.10-1.6]), hematoma/seroma formation (2.31[1.92-2.78]), accidental vessel or nerve puncture (1.44[1.29-1.61]), wound dehiscence (2.18[1.48-3.21]), postop infection (3.10[2.50-3.85]), and ARDS complications (1.43[1.28-1.60]). The primary cohort had a decreased risk for GI (0.65[0.55-0.76]) and GU complications (0.71[0.51-0.99]).Conclusion: Relative to primary cases, those undergoing revision correction of spinal deformity have a higher risk of many procedure-related complications with a longer hospital course despite similar baseline comorbidity burden and the in-hospital mortality rate. This study provides clinically useful data for surgeons to educate patients at risk for morbidity and mortality and direct future research to improve outcomes. [ABSTRACT FROM AUTHOR]- Published
- 2015
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21. Friday, September 28, 2018 3:00 PM–4:00 PM abstracts: the gravity of obesity: 226. Prior bariatric surgery lowers complication rates following spine surgery in obese patients.
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Passias, Peter G., Horn, Samantha R., Vasquez-Montes, Dennis, Segreto, Frank A., Bortz, Cole, Poorman, Gregory W., Jalai, Cyrus M., Wang, Charles, Frangella, Nicholas J., Stekas, Nicholas, Deflorimonte, Chloe, Raad, Micheal, Diebo, Bassel G., Vira, Shaleen N., Horowitz, Jason A., Hassanzadeh, Hamid, Lafage, Renaud, Afthinos, John, and Lafage, Virginie
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SPINAL surgery , *OBESITY complications , *SURGICAL complications , *BARIATRIC surgery , *BONE metabolism - Abstract
BACKGROUND CONTEXT Bariatric surgery is an increasingly common treatment for morbid obesity that has the potential to effect bone and mineral metabolism. The effect of prior bariatric surgery on outcomes following spinal surgery has not been well-established. PURPOSE To assess differences in complication rates following spinal surgery for patients with and without a history of bariatric surgery. STUDY DESIGN/SETTING Retrospective analysis of the prospectively collected New York State Inpatient Database (NYSID) years (2004–2013). PATIENT SAMPLE A total of 1,939 patients with prior bariatric surgery now undergoing spine surgery, 1,625 overweight or obese spine surgery patients (no bariatric procedures), and 28,304 spine surgery patients who are not obese or overweight. OUTCOME MEASURES Complications following spine surgery. METHODS Retrospective analysis of the prospectively collected New York State Inpatient Database (NYSID) years 2004-2013. Patient linkage codes allow identification of multiple and return inpatient stays within the time-frame analyzed. Complication rates were compared between bariatric surgery patients now undergoing spine surgery versus morbidly obese patients having spine surgery. Bariatric surgery (BS) patients and morbidly obese patients (non-BS) were divided into cervical and thoracolumbar surgical groups and were propensity score matched for age, gender and degree of invasiveness. Nonobese spine surgery patients were used as a standard. RESULTS A total of 1,939 spine surgery patients with a history of BS were compared to 1,625 non-BS spine surgery patients in the NYSID database. A total of 89% of normal weight spine surgery patients had a decompression and the overall complication rate for these patients is 45%. The average time from bariatric surgery to spine surgery is 2.95 years. BS patients had primarily two-three level fusions and decompressions, which is similar to non-BS patients. After propensity score matching for age, gender and invasiveness, 740 BS patients were compared to 740 non-BS patients undergoing thoracolumbar surgery, with similar comorbidity rates between cohorts. The overall complication rate for BS patients undergoing thoracolumbar surgery was significantly lower than non-BS patients (45.8% vs. 58.1%, P<.001). The most common complications following thoracolumbar surgery for BS patients were anemia (20.3%), bowel issues (12.3%), device-related complications (6.1%), and digestive problems (5.0%). BS patients undergoing a thoracolumbar procedure experienced lower rates of device-related complications (6.1% vs. 23.2%, P<.001), DVT (1.2% vs. 2.7%, P=.039), and hematomas (1.5% vs. 4.5%, P<.001) than non-BS patients undergoing thoracolumbar surgery. Neurologic complications were similar between BS patients and non-BS patients (2.3% vs. 2.7%, P=.62) and this rate was similar to normal weight patients undergoing spine procedures (1.65%). Spine surgery revision rates for BS patients was 14.9% and the average length of stay for BS patients undergoing spine surgery was higher than non-BS patients undergoing thoracolumbar surgery (5.95 days vs. 5.14 days, P=.007). For patients undergoing cervical spine surgery, BS patients experienced lower rates of bowel issues, device-related, and overall complication rates than non-BS patients (all P>.05). CONCLUSIONS Bariatric surgery patients undergoing spine surgery experience lower overall complication rates than morbidly obese patients. This study warrants further investigation into these populations to mitigate risks associated with spine surgery for bariatric patients. [ABSTRACT FROM AUTHOR]
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- 2018
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22. P33 - The Fate of Adult Spinal Deformity Patients Incurring Rod Fracture after Thoracolumbar Fusion without Prior 3-Column Osteotomy.
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Hamilton, D. Kojo, Buza, John, Passias, Peter G., Jalai, Cyrus M., Kim, Han Jo, Hart, Robert A., Ailon, Tamir, Gupta, Munish C., Ames, Christopher P., Deviren, Vedat, Daniels, Alan H., Lafage, Virginie, Bess, Shay, Klineberg, Eric O., Shaffrey, Christopher I., Jain, Amit, and Smith, Justin S.
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SPINAL injury treatment , *SPINE abnormalities , *OSTEOTOMY , *QUALITY of life , *SURGICAL complications , *RETROSPECTIVE studies , *THERAPEUTICS ,DISEASES in adults - Published
- 2016
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