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Your search keyword '"PALADINO, Nunzia Cinzia"' showing total 7 results
Start Over Author "PALADINO, Nunzia Cinzia" Topic surgery
7 results on '"PALADINO, Nunzia Cinzia"'

2. Diagnostic Rechallenge with 18F-FCH PET/CT Often Allows Minimally Invasive Parathyroidectomy While Maintaining Exceptional Cure Rates

Author

Goren, Shani, Paladino, Nunzia Cinzia, Laks, Shachar, Cuny, Thomas, Vaillant-Lombard, Josiane, Mennetrey, Clément, Assaf, Dan, Hindié, Elif, Guerin, Carole, Fargette, Christelle, Taïeb, David, Sebag, Fréderic, Centre Européen de Recherche en Imagerie médicale (CERIMED), Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-École Centrale de Marseille (ECM)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Centre National de la Recherche Scientifique (CNRS), Service de médecine nucléaire [Marseille], and Université de la Méditerranée - Aix-Marseille 2-Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE)

Subjects
Surgery, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

International audience

Published
2022
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4. Transoral endoscopic thyroidectomy vestibular approach (TOETVA). Recommendations of the AFCE (Francophone Association of Endocrine Surgery) with the SFE (French Society of Endocrinology) and the SFMN (French Society of Nuclear Medicine).

Author

Chereau, Nathalie, Paladino, Nunzia Cinzia, Nomine Criqui, Claire, Tresallet, Christophe, Deroide, Gregoire, and Caiazzo, Robert

Subjects
THYROIDECTOMY, NUCLEAR medicine, PERIOPERATIVE care, PATIENT satisfaction, POSTOPERATIVE pain, SURGERY
Abstract

Transoral endoscopic thyroidectomy vestibular approach (TOETVA) can be proposed for selected patients with a thyroid volume < 45 mL and/or a nodule < 4 cm (for Bethesda category II, III or IV lesions), or < 2 cm (for Bethesda category V or VI lesions), with no suspicion of lateral nodal involvement or mediastinal extension who wish to avoid a cervical scar. Such patients should have satisfactory dental status, have been educated on the specific risks of the transoral route and the need for perioperative oral care, and also fully informed regarding the lack of proof of TOETVA effectiveness in terms of quality of life and patient satisfaction. The patient should be made aware of the possibility of postoperative pain in the neck cervical and chin, which may persist for several days to a few weeks after the intervention. Transoral endoscopic thyroidectomy should be performed in centers with expertise in thyroid surgery. [ABSTRACT FROM AUTHOR]

Published
2023
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5. Editorial: Recent Advances in Thyroid Surgery.

Author

Scerrino, Gregorio, Richiusa, Pierina, Graceffa, Giuseppa, Lori, Eleonora, Sorrenti, Salvatore, and Paladino, Nunzia Cinzia

Subjects
INTRAOPERATIVE monitoring, THYROIDECTOMY, THYROID gland, PREOPERATIVE risk factors, RECURRENT laryngeal nerve, LARYNGEAL nerve palsy, SURGERY
Abstract

Thyroid surgery developed over the course of three centuries: from the 19th century, when it originated, thyroid surgery went through a stabilization phase and a huge innovation phase, due to continuous technological improvements. Albeit there are two different application principles, the methods of using fluorescence in thyroid surgery seem to be promising for reducing post-thyroidectomy hypocalcemia. Thyroid surgery has been, since its earliest application, one of the most notable fields in medicine, illustrated by the fact that the Nobel Prize in Medicine was won, for the first time, for thyroid surgery by Emil Theodor Kocher (1841-1917) in 1909, for his contributions to thyroid physiology, pathology, and surgery [[1]]. If we take into consideration the three main complications of thyroid surgery (bleeding, hypocalcemia, and laryngeal nerve palsy), we can see that the products introduced by pharmaceutical and technological companies have helped a lot in controlling their incidence. [Extracted from the article]

Published
2022
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6. Value of 123I/99mTc-sestamibi parathyroid scintigraphy with subtraction SPECT/CT in primary hyperparathyroidism for directing minimally invasive parathyroidectomy

Author

Paladino, Nunzia Cinzia, Guérin, Carole, Abdullah, Ahmad Esmaeel, Taieb, David, Asseeva, Pauline, Paladino, NC, Guerin, c, Castinetti, Frederic, Vaillant-Lombard, Josiane, Abdullah, AE, Farman-Ara, Bardia, Loundou, Anderson, Sebag, Frédéric, Taïeb, D, Service de médecine nucléaire [Marseille], Université de la Méditerranée - Aix-Marseille 2-Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE), Centre de Recherche en Cancérologie de Marseille (CRCM), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Aix Marseille Université (AMU), Centre de recherche en neurobiologie - neurophysiologie de Marseille (CRN2M), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre d'études et de recherche sur les services de santé et la qualité de vie (CEReSS), Aix Marseille Université (AMU), Service de chirurgie générale et endocrinienne, Hôpital de la Timone [CHU - APHM] (TIMONE), Physiologie, Environnement et Génétique pour l'Animal et les Systèmes d'Elevage [Rennes] (PEGASE), Institut National de la Recherche Agronomique (INRA)-AGROCAMPUS OUEST, Imagerie MOléculaire pour applications THéranostiques personnalisées (IMOTHEP), Institut FRESNEL (FRESNEL), Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS)- Hôpital de la Timone [CHU - APHM] (TIMONE), Aix Marseille Université (AMU)-Institut Paoli-Calmettes, and Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Parathyroidectomy, endocrine system diseases, Radionuclide imaging, medicine.medical_treatment, Mini-invasive surgery, Scintigraphy, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, medicine, Hyperparathyroidism, medicine.diagnostic_test, business.industry, Subtraction, General Medicine, 99mTc Sestamibi, medicine.disease, 3. Good health, Parathyroid scintigraphy, 030220 oncology & carcinogenesis, Surgery, Nuclear medicine, business, Minimally invasive parathyroidectomy, Primary hyperparathyroidism, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

Background Primary hyperparathyroidism/(PHPT) is one of the most common endocrinological conditions. Surgery remains the only curative option. We have evaluated the performance of double isotope 123I/99mTc-sestamibi parathyroid scintigraphy/(PS) with subtraction SPECT/CT in PHP for identifying uniglandular disease. Methods Ninety PHPT patients undergoing parathyroidectomy (December 2015–August 2016) were included. All patients were evaluated with neck ultrasound/(US), PS and SPECT/CT with a new protocol. Outcomes from imaging modalities were reported as: uniglandular disease/(UGD), multiglandular disease/(MGD), or negative, and were compared to post-operative diagnoses. Results Post-operatively, 72 and 18 patients had true UGD and MGD, respectively. Sensitivities and specificities of US, pinhole scintigraphy with subtraction, pinhole and SPECT/CT with subtraction, and all modalities combined were 91.7%/38.9%, 88.9%/72.2%, 93%/66.7% and 84.72%/77.78%, respectively: specificity of US + PS superior to US alone, p = 0.074. SPECT/CT enables reclassification of doubtful uptake foci. Conclusions Combination of neck US and PS with subtraction SPECT/CT offers a higher specificity for guiding towards minimally invasive parathyroidectomy.

Published
2019
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7. Implications of SDHB genetic testing in patients with sporadic pheochromocytoma

Author

MAIGNAN, AURELIE, Guerin, Carole, Julliard, Valentin, Paladino, Nunzia-Cinzia, Kim, Edward, Roche, Philippe, Castinetti, Frederic, Essamet, Wassim, Mancini, Julien, Imperiale, Alessio, Clifton-Bligh, Roderick, Romanet, Pauline, Barlier, Anne, Pacak, Karel, Sebag, Frédéric, Taieb, David, Maignan, Aurélie, Centre de Recherche en Cancérologie de Marseille (CRCM), Aix Marseille Université (AMU)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre de recherche en neurobiologie - neurophysiologie de Marseille (CRN2M), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Service de Neuropathologie [AP-HM Hôpital de la Timone], Hôpital de la Timone [CHU - APHM] (TIMONE)-Assistance Publique - Hôpitaux de Marseille (APHM), Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale (SESSTIM - U912 INSERM - Aix Marseille Univ - IRD), Institut de Recherche pour le Développement (IRD)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Aix Marseille Université (AMU), Service de Biophysique et Médecine Nucléaire, CHU Strasbourg-Université Louis Pasteur - Strasbourg I-Hôpital de Hautepierre [Strasbourg], Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), Service de chirurgie générale et endocrinienne, Hôpital de la Timone [CHU - APHM] (TIMONE), Service de médecine nucléaire [Marseille], Université de la Méditerranée - Aix-Marseille 2-Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE), Physiologie, Environnement et Génétique pour l'Animal et les Systèmes d'Elevage [Rennes] (PEGASE), Institut National de la Recherche Agronomique (INRA)-AGROCAMPUS OUEST, Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Aix Marseille Université (AMU), Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), and MITOYAN, Louciné

Subjects
0301 basic medicine, Oncology, Male, Pathology, Magnetic Resonance Spectroscopy, SDHB, Radionuclide imaging, [SDV]Life Sciences [q-bio], MESH: Laparoscopy, DNA Mutational Analysis, Adrenal Gland Neoplasms, medicine.disease_cause, Germline, Loss of heterozygosity, 0302 clinical medicine, MESH: Fluorodeoxyglucose F18, Positron Emission Tomography Computed Tomography, MESH: Germ-Line Mutation, MESH: DNA Mutational Analysis, MESH: Adrenalectomy, MESH: Aged, Mutation, MESH: Middle Aged, medicine.diagnostic_test, MESH: Genetic Testing, Adrenalectomy, Middle Aged, Immunohistochemistry, 3. Good health, [SDV] Life Sciences [q-bio], Succinate Dehydrogenase, 030220 oncology & carcinogenesis, Female, MESH: Radiopharmaceuticals, Adult, medicine.medical_specialty, Blotting, Western, Context (language use), [SDV.CAN]Life Sciences [q-bio]/Cancer, Pheochromocytoma, Malignancy, Article, 03 medical and health sciences, [SDV.CAN] Life Sciences [q-bio]/Cancer, Fluorodeoxyglucose F18, Internal medicine, medicine, MESH: Blotting, Western, Humans, MESH: Pheochromocytoma, Genetic Testing, Germ-Line Mutation, Genetic testing, Aged, MESH: Humans, business.industry, MESH: Magnetic Resonance Spectroscopy, MESH: Adult, MESH: Immunohistochemistry, medicine.disease, MESH: Adrenal Gland Neoplasms, MESH: Succinate Dehydrogenase, MESH: Male, 030104 developmental biology, Pheochromocytomas, Surgery, Laparoscopy, MESH: Positron Emission Tomography Computed Tomography, Radiopharmaceuticals, business, MESH: Female
Abstract

International audience; PURPOSE: Succinate dehydrogenase B (SDHB) associated pheochromocytomas (PHEOs) are associated with a higher risk of tumor aggressiveness and malignancy. The aim of the present study was to evaluate (1) the frequency of germline SDHB mutations in apparently sporadic patients with PHEO who undergo preoperative genetic testing and (2) the ability to predict pathogenic mutations.METHODS: From 2012 to 2016, 82 patients underwent a PHEO surgical resection. Sixteen were operated in the context of hereditary PHEO and were excluded from analysis. Among the 66 remaining cases, 48 were preoperatively screened for an SDHB mutation. In addition to imaging studies with specific radiopharmaceuticals (123I-MIBG or 18F-FDOPA) for exclusion of multifocality/metastases, 36 patients underwent 18F-FDG PET/CT.RESULTS: From the 48 genetically screened patients, genetic testing found a germline SDHB variant in two (4.2%) cases: a variant of unknown significance, exon 1, c.14T>G (p.Val5Gly), and a most likely pathogenic mutation, exon 5, c.440A>G (p.Tyr147Cys), according to in silico analysis. Structural and functional analyses of the protein predicted that p.Tyr147Cys mutant was pathogenic. Both tumors exhibited moderate 18F-FDG PET uptake with similar uptake patterns to non-SDHB mutated PHEOs. The two patients underwent total laparoscopic adrenalectomies. Of the remaining patients, 44 underwent a laparoscopic adrenalectomy, and two had an open approach. Pathological analysis of the tumors from patients bearing two germline SDHB variants revealed a typical PHEO (PASS 0 and 2). Ex-vivo analyses (metabolomics, SDHB immunohistochemistry, loss of heterozygosity analysis) allowed a reclassification of the two SDHB variants as probably non-pathogenic variants.CONCLUSIONS:This study illustrates that SDHx mutational analysis can be misleading, even if structural and functional analyses are done. Surgeons should be aware of the difficulty of classifying new SDHB variants prior to implementing SDHB mutation status into a tailored surgical management strategy of a patient.

Published
2016
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